Robustine
Robustine structure
|
Common Name | Robustine | ||
|---|---|---|---|---|
| CAS Number | 2255-50-7 | Molecular Weight | 215.205 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 411.9±40.0 °C at 760 mmHg | |
| Molecular Formula | C12H9NO3 | Melting Point | 148-149℃ (ethanol ) | |
| MSDS | N/A | Flash Point | 202.9±27.3 °C | |
Use of RobustineRobustine, a furoquinoline alkaloid, from Dictamnus albus, exhibits inhibitory potency against human phosphodiesterase 5 (hPDE5A) in vitro[1]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | robustine |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Robustine, a furoquinoline alkaloid, from Dictamnus albus, exhibits inhibitory potency against human phosphodiesterase 5 (hPDE5A) in vitro[1]. |
|---|---|
| Related Catalog | |
| Target |
PDE5A |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 411.9±40.0 °C at 760 mmHg |
| Melting Point | 148-149℃ (ethanol ) |
| Molecular Formula | C12H9NO3 |
| Molecular Weight | 215.205 |
| Flash Point | 202.9±27.3 °C |
| Exact Mass | 215.058243 |
| PSA | 55.49000 |
| LogP | 2.73 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.708 |
| InChIKey | VGVNNMLKTSWBAR-UHFFFAOYSA-N |
| SMILES | COc1c2ccoc2nc2c(O)cccc12 |
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Hazard Codes | Xi |
|---|
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
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~96%
Robustine CAS#:2255-50-7 |
| Literature: Boyd, Derek R.; Sharma, Narain D.; Carroll, Jonathan G.; Loke, Pui L.; O'Dowd, Colin R.; Allen, Christopher C. R. RSC Advances, 2013 , vol. 3, # 27 p. 10944 - 10955 |
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Robustine CAS#:2255-50-7 |
| Literature: Boyd, Derek R.; Sharma, Narain D.; O'Dowd, Colin R.; Carroll, Jonathan G.; Loke, Pui L.; Allen, Christopher C. R. Chemical Communications, 2005 , # 31 p. 3989 - 3991 |
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~%
Robustine CAS#:2255-50-7 |
| Literature: Boyd, Derek R.; Sharma, Narain D.; Carroll, Jonathan G.; Loke, Pui L.; O'Dowd, Colin R.; Allen, Christopher C. R. RSC Advances, 2013 , vol. 3, # 27 p. 10944 - 10955 |
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~%
Robustine CAS#:2255-50-7 |
| Literature: Ramachandran,V.N. et al. Indian Journal of Chemistry, 1973 , vol. 11, p. 1088 - 1091 |
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~%
Robustine CAS#:2255-50-7 |
| Literature: Ramachandran,V.N. et al. Indian Journal of Chemistry, 1973 , vol. 11, p. 1088 - 1091 |
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~%
Robustine CAS#:2255-50-7 |
| Literature: Ramachandran,V.N. et al. Indian Journal of Chemistry, 1973 , vol. 11, p. 1088 - 1091 |
|
~%
Robustine CAS#:2255-50-7 |
| Literature: Abdullaeva,Kh.A. et al. Chemistry of Natural Compounds, 1978 , vol. 14, p. 179 - 182 Khimiya Prirodnykh Soedinenii, 1978 , vol. 14, p. 219 - 223 |
|
~%
Robustine CAS#:2255-50-7 |
| Literature: Boyd, Derek R.; Sharma, Narain D.; Carroll, Jonathan G.; Loke, Pui L.; O'Dowd, Colin R.; Allen, Christopher C. R. RSC Advances, 2013 , vol. 3, # 27 p. 10944 - 10955 |
![(7S,8R)-4-methoxy-7,8-dihydrofuro[2,3-b]quinoline-7,8-diol structure](https://image.chemsrc.com/caspic/025/865878-14-4.png)
![(7S,8R)-4-methoxy-5,6,7,8-tetrahydrofuro[2,3-b]quinoline-7,8-diol structure](https://image.chemsrc.com/caspic/394/865878-22-4.png)
![4-methoxy-8-(3-methyl-but-2-enyloxy)-furo[2,3-b]quinoline structure](https://image.chemsrc.com/caspic/301/55727-61-2.png)
![4-chlorofuro[2,3-b]quinoline structure](https://image.chemsrc.com/caspic/160/111163-82-7.png)
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 5 | |
|---|---|
| DownStream 1 | |
CAS#:524-15-2This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 4-Methoxyfuro[2,3-b]quinolin-8-ol |
| 8-hydroxydictamnine |
| 8-Hydroxy-4-methoxy-furo<2,3-b>chinolin |
| 8-Hydroxydictamnin |
| Robustine |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the LogP of robustine? |
| A: LogP of robustine is 2.73. |
| Q: What English synonyms does robustine have? |
| A: English synonyms of robustine: 4-Methoxyfuro[2,3-b]quinolin-8-ol, 8-hydroxydictamnine, 8-Hydroxy-4-methoxy-furochinolin, 8-Hydroxydictamnin, Robustine. |
| Q: What is the SMILES notation of robustine? |
| A: SMILES notation of robustine is COc1c2ccoc2nc2c(O)cccc12. |
| Q: What are the upstream materials of robustine? |
| A: Related upstream materials(CAS) of robustine: 865878-14-4;865878-22-4;484-29-7;111163-82-7;55727-61-2. |
| Q: What is the CAS number of robustine? |
| A: CAS number of robustine is 2255-50-7. |
| Q: What are the uses of robustine? |
| A: Main uses of robustine: Robustine, a furoquinoline alkaloid, from Dictamnus albus, exhibits inhibitory potency against human phosphodiesterase 5 (hPDE5A) in vitro[1]. |
| Q: What is the polar surface area (PSA) of robustine? |
| A: Polar surface area (PSA) of robustine is 55.49000. |
| Q: What is the InChIKey of robustine? |
| A: InChIKey of robustine is VGVNNMLKTSWBAR-UHFFFAOYSA-N. |
| Q: What is the boiling point of robustine? |
| A: Boiling point of robustine is 411.9±40.0 °C at 760 mmHg. |
| Q: What is the English name of robustine? |
| A: The English name of robustine is robustine. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| BioBioPha |
| Dayang Chem (Hangzhou) Co., Ltd. |
| naturewill |