Robustine

Modify Date: 2025-08-24 20:06:19

Robustine Structure
Robustine structure
 Common Name Robustine
CAS Number 2255-50-7 Molecular Weight 215.205
Density 1.4±0.1 g/cm3 Boiling Point 411.9±40.0 °C at 760 mmHg
Molecular Formula C12H9NO3 Melting Point 148-149℃ (ethanol )
MSDS N/A Flash Point 202.9±27.3 °C

 Use of Robustine


Robustine, a furoquinoline alkaloid, from Dictamnus albus, exhibits inhibitory potency against human phosphodiesterase 5 (hPDE5A) in vitro[1].

 Names

Name robustine
Synonym More Synonyms

 Robustine Biological Activity

Description Robustine, a furoquinoline alkaloid, from Dictamnus albus, exhibits inhibitory potency against human phosphodiesterase 5 (hPDE5A) in vitro[1].
Related Catalog
Target

PDE5A

References

[1]. Nam KW, et al. Inhibitory effects of furoquinoline alkaloids from Melicope confusa and Dictamnus albus against human phosphodiesterase 5 (hPDE5A) in vitro. Arch Pharm Res. 2005 Jun;28(6):675-9.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 411.9±40.0 °C at 760 mmHg
Melting Point 148-149℃ (ethanol )
Molecular Formula C12H9NO3
Molecular Weight 215.205
Flash Point 202.9±27.3 °C
Exact Mass 215.058243
PSA 55.49000
LogP 2.73
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.708
InChIKey VGVNNMLKTSWBAR-UHFFFAOYSA-N
SMILES COc1c2ccoc2nc2c(O)cccc12

 Safety Information

Hazard Codes Xi

 Synthetic Route

(7S,8R)-4-methoxy-7,8-dihydrofuro[2,3-b]quinoline-7,8-diol structure

(7S,8R)-4-metho...

CAS#:865878-14-4

~96%

Robustine Structure

Robustine

CAS#:2255-50-7

Literature: Boyd, Derek R.; Sharma, Narain D.; Carroll, Jonathan G.; Loke, Pui L.; O'Dowd, Colin R.; Allen, Christopher C. R. RSC Advances, 2013 , vol. 3, # 27 p. 10944 - 10955
(7S,8R)-4-methoxy-5,6,7,8-tetrahydrofuro[2,3-b]quinoline-7,8-diol structure

(7S,8R)-4-metho...

CAS#:865878-22-4

~%

Robustine Structure

Robustine

CAS#:2255-50-7

Literature: Boyd, Derek R.; Sharma, Narain D.; O'Dowd, Colin R.; Carroll, Jonathan G.; Loke, Pui L.; Allen, Christopher C. R. Chemical Communications, 2005 , # 31 p. 3989 - 3991
Dictamnine structure

Dictamnine

CAS#:484-29-7

~%

Robustine Structure

Robustine

CAS#:2255-50-7

Literature: Boyd, Derek R.; Sharma, Narain D.; Carroll, Jonathan G.; Loke, Pui L.; O'Dowd, Colin R.; Allen, Christopher C. R. RSC Advances, 2013 , vol. 3, # 27 p. 10944 - 10955
2-(2-benzyloxy-anilino)-4-hydroxy-furan-3-carboxylic acid ethyl ester structure

2-(2-benzyloxy-...

CAS#:52336-79-5

~%

Robustine Structure

Robustine

CAS#:2255-50-7

Literature: Ramachandran,V.N. et al. Indian Journal of Chemistry, 1973 , vol. 11, p. 1088 - 1091
N/A structure

N/A

CAS#:52336-81-9

~%

Robustine Structure

Robustine

CAS#:2255-50-7

Literature: Ramachandran,V.N. et al. Indian Journal of Chemistry, 1973 , vol. 11, p. 1088 - 1091
N/A structure

N/A

CAS#:52336-80-8

~%

Robustine Structure

Robustine

CAS#:2255-50-7

Literature: Ramachandran,V.N. et al. Indian Journal of Chemistry, 1973 , vol. 11, p. 1088 - 1091
4-methoxy-8-(3-methyl-but-2-enyloxy)-furo[2,3-b]quinoline structure

4-methoxy-8-(3-...

CAS#:55727-61-2

~%

Robustine Structure

Robustine

CAS#:2255-50-7

Literature: Abdullaeva,Kh.A. et al. Chemistry of Natural Compounds, 1978 , vol. 14, p. 179 - 182 Khimiya Prirodnykh Soedinenii, 1978 , vol. 14, p. 219 - 223
4-chlorofuro[2,3-b]quinoline structure

4-chlorofuro[2,...

CAS#:111163-82-7

~%

Robustine Structure

Robustine

CAS#:2255-50-7

Literature: Boyd, Derek R.; Sharma, Narain D.; Carroll, Jonathan G.; Loke, Pui L.; O'Dowd, Colin R.; Allen, Christopher C. R. RSC Advances, 2013 , vol. 3, # 27 p. 10944 - 10955

 Synonyms

4-Methoxyfuro[2,3-b]quinolin-8-ol
8-hydroxydictamnine
8-Hydroxy-4-methoxy-furo<2,3-b>chinolin
8-Hydroxydictamnin
Robustine
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