Vasicinone
Modify Date: 2025-08-25 18:47:32
Vasicinone structure
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Common Name | Vasicinone | ||
|---|---|---|---|---|
| CAS Number | 486-64-6 | Molecular Weight | 202.209 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 409.8±47.0 °C at 760 mmHg | |
| Molecular Formula | C11H10N2O2 | Melting Point | 200-202ºC | |
| MSDS | N/A | Flash Point | 201.7±29.3 °C | |
Use of VasicinoneVasicinone is a quinazoline alkaloid isolated from the Adhatoda vasica plant. Vasicinone is a potential agent for Parkinson's disease and possibly other oxidative stress-related neurodegenerative disorders[1]. |
| Name | vasicinone |
|---|---|
| Synonym | More Synonyms |
| Description | Vasicinone is a quinazoline alkaloid isolated from the Adhatoda vasica plant. Vasicinone is a potential agent for Parkinson's disease and possibly other oxidative stress-related neurodegenerative disorders[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Vasicinone (1~30 µM; 24 hours; SH-SY5Y cells) significantly reverses the paraquat-induced reduction in cell viability[1]. Vasicinone (10 and 15 μM; 24 hours; SH-SY5Y cells) abates the paraquat-induced injury of SH-SY5Y cells by suppressing the MAPK signaling pathway, dose-dependently reduces the percentage of apoptotic cells and is capable of rescuing paraquat-induced apoptotic death[1]. Vasicinone (10 and 15 μM; SH-SY5Y cells) attenuates the paraquat-induced accumulation of reactive oxygen species (ROS) and attenuates the paraquat-induced expression of apoptotic proteins[1]. Cell Viability Assay[1] Cell Line: SH-SY5Y cells Concentration: 1~30 µM Incubation Time: 24 hours Result: Significantly reversed the paraquat-induced reduction in cell viability. Western Blot Analysis[1] Cell Line: SH-SY5Y cells Concentration: 10 and 15 µM Incubation Time: 24 hours Result: Abated the paraquat-induced injury of SH-SY5Y cells by suppressing the MAPK signaling pathway. Apoptosis Analysis[1] Cell Line: SH-SY5Y cells Concentration: 10 and 15 µM Incubation Time: 24 hours Result: Dose-dependently reduced the percentage of apoptotic cells. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 409.8±47.0 °C at 760 mmHg |
| Melting Point | 200-202ºC |
| Molecular Formula | C11H10N2O2 |
| Molecular Weight | 202.209 |
| Flash Point | 201.7±29.3 °C |
| Exact Mass | 202.074234 |
| PSA | 55.12000 |
| LogP | -0.40 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.743 |
| InChIKey | SDIVYZXRQHWCKF-VIFPVBQESA-N |
| SMILES | O=c1c2ccccc2nc2n1CCC2O |
| Storage condition | 2-8℃ |
| Hazard Codes | Xi |
|---|
| Precursor 9 | |
|---|---|
| DownStream 0 | |
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Name: Bronchodilatory activity in Wistar rat trachea assessed as inhibition of carbacol-ind...
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL3124421
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Name: Cytotoxicity against human PC3 cells assessed as reduction in cell viability by MTT a...
Source: ChEMBL
Target: PC-3
External Id: CHEMBL4182819
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Name: Cytotoxicity against human HL60 cells assessed as reduction in cell viability by tryp...
Source: ChEMBL
Target: HL-60
External Id: CHEMBL4182820
|
|
Name: Cytotoxicity against human SGC7901 cells assessed as reduction in cell viability by M...
Source: ChEMBL
Target: SGC-7901
External Id: CHEMBL4182821
|
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| (3S)-3-Hydroxy-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one |
| Vasicinone |
| L-vasicinone |
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- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Vasicinone
- Price: Check
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Yang
- Email: sales@echemcloud.com
- BioBioPha
- China
- Product Name: Vasicinone
- Price: ￥1600.0/5mg
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Xueping-Zheng
- Email: 1477035482@qq.com
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Vasicinone
- Price: ￥3520.0/5mg
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Liu jia
- Email: 2130147988@qq.com
- Henan Tianfu Chemical Co., Ltd.
- China
- Product Name: Pyrrolo[2,1-b]quinazolin-9(1H)-one,2,3-dihydro-3-hydroxy-, (3S)-
- Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
- Purity: 99.0%
- Delivery: Inquiry
- Contact: Anson
- Email: info@tianfuchem.com
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