- BioBioPha
- China
- Product Name: Vasicinone
- Price: ￥2500.0/5mg
- Purity: 98.0%
- Stocking Period: 1 Day
- Contact: Xueping-Zheng
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Vasicinone
- Price: ￥3520.0/5mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: Vasicinone
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Henan Tianfu Chemical Co., Ltd.
- China
- Product Name: Pyrrolo[2,1-b]quinazolin-9(1H)-one,2,3-dihydro-3-hydroxy-, (3S)-
- Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
- Purity: 99.0%
- Stocking Period: Inquiry
- Contact: Anson
486-64-6
486-64-6 structure
- Name: Vasicinone
- Chemical Name: vasicinone
- CAS Number: 486-64-6
- Molecular Formula: C11H10N2O2
- Molecular Weight: 202.209
- Catalog: Natural product Alkaloid
- Create Date: 2018-02-14 08:00:00
- Modify Date: 2024-01-03 17:46:58
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Vasicinone is a quinazoline alkaloid isolated from the Adhatoda vasica plant. Vasicinone is a potential agent for Parkinson's disease and possibly other oxidative stress-related neurodegenerative disorders[1].
| Name | vasicinone |
|---|---|
| Synonyms |
(3S)-3-Hydroxy-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
Pyrrolo[2,1-b]quinazolin-9(1H)-one, 2,3-dihydro-3-hydroxy-, (3S)- Vasicinone L-vasicinone |
| Description | Vasicinone is a quinazoline alkaloid isolated from the Adhatoda vasica plant. Vasicinone is a potential agent for Parkinson's disease and possibly other oxidative stress-related neurodegenerative disorders[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Vasicinone (1~30 µM; 24 hours; SH-SY5Y cells) significantly reverses the paraquat-induced reduction in cell viability[1]. Vasicinone (10 and 15 μM; 24 hours; SH-SY5Y cells) abates the paraquat-induced injury of SH-SY5Y cells by suppressing the MAPK signaling pathway, dose-dependently reduces the percentage of apoptotic cells and is capable of rescuing paraquat-induced apoptotic death[1]. Vasicinone (10 and 15 μM; SH-SY5Y cells) attenuates the paraquat-induced accumulation of reactive oxygen species (ROS) and attenuates the paraquat-induced expression of apoptotic proteins[1]. Cell Viability Assay[1] Cell Line: SH-SY5Y cells Concentration: 1~30 µM Incubation Time: 24 hours Result: Significantly reversed the paraquat-induced reduction in cell viability. Western Blot Analysis[1] Cell Line: SH-SY5Y cells Concentration: 10 and 15 µM Incubation Time: 24 hours Result: Abated the paraquat-induced injury of SH-SY5Y cells by suppressing the MAPK signaling pathway. Apoptosis Analysis[1] Cell Line: SH-SY5Y cells Concentration: 10 and 15 µM Incubation Time: 24 hours Result: Dose-dependently reduced the percentage of apoptotic cells. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 409.8±47.0 °C at 760 mmHg |
| Melting Point | 200-202ºC |
| Molecular Formula | C11H10N2O2 |
| Molecular Weight | 202.209 |
| Flash Point | 201.7±29.3 °C |
| Exact Mass | 202.074234 |
| PSA | 55.12000 |
| LogP | -0.40 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.743 |
| Storage condition | 2-8℃ |
| Hazard Codes | Xi |
|---|
| Precursor 9 | |
|---|---|
| DownStream 0 | |
![1-[1(S),3-dihydroxypropyl]quinazolin-4(1H)-one structure](https://www.chemsrc.com/caspic/043/391249-56-2.png)
![2,3-Dihydropyrrolo[2,1-b]quinazolin-9(1H)-one structure](https://www.chemsrc.com/caspic/084/530-53-0.png)
![3-bromo-2,3-dihydro-1H-pyrrolo[2,1-b]quinazolin-9-one structure](https://www.chemsrc.com/caspic/213/71540-68-6.png)
