CIQ
Modify Date: 2026-07-14 10:26:17
CIQ structure
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Common Name | CIQ | ||
|---|---|---|---|---|
| CAS Number | 486427-17-2 | Molecular Weight | 467.941 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 635.8±55.0 °C at 760 mmHg | |
| Molecular Formula | C26H26ClNO5 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 338.3±31.5 °C | |
| Symbol |
GHS09 |
Signal Word | Warning | |
Use of CIQCIQ is a subunit-selective potentiator of NMDA receptors containing the NR2C or NR2D subunit. IC50 value: 2.7 μM (EC50, for NR2C) and 2.8 μM (EC50, NR2D)Target: NMDA receptorCIQ increases channel opening frequency of recombinant NR2Cor NR2D containing receptors by two-fold (EC50 = 2.7 and 2.8 μM, respectively), with no effect on NR2A or NR2B subtypes. CIQ does not alter the EC50 values for glutamate or glycine on channel opening. CIQ increases channel opening efficiency and enhances NMDA receptor responses. CIQ reduces associated behaviours in schizophrenia models and potentially enhances dopamine release in Parkinson's disease models. |
| Name | (3-Chlorophenyl){6,7-dimethoxy-1-[(4-methoxyphenoxy)methyl]-3,4-d ihydro-2(1H)-isoquinolinyl}methanone |
|---|---|
| Synonym | More Synonyms |
| Description | CIQ is a subunit-selective potentiator of NMDA receptors containing the NR2C or NR2D subunit. IC50 value: 2.7 μM (EC50, for NR2C) and 2.8 μM (EC50, NR2D)Target: NMDA receptorCIQ increases channel opening frequency of recombinant NR2Cor NR2D containing receptors by two-fold (EC50 = 2.7 and 2.8 μM, respectively), with no effect on NR2A or NR2B subtypes. CIQ does not alter the EC50 values for glutamate or glycine on channel opening. CIQ increases channel opening efficiency and enhances NMDA receptor responses. CIQ reduces associated behaviours in schizophrenia models and potentially enhances dopamine release in Parkinson's disease models. |
|---|---|
| Related Catalog |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 635.8±55.0 °C at 760 mmHg |
| Molecular Formula | C26H26ClNO5 |
| Molecular Weight | 467.941 |
| Flash Point | 338.3±31.5 °C |
| Exact Mass | 467.149963 |
| PSA | 57.23000 |
| LogP | 4.56 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.590 |
| InChIKey | VYMILMYEENZHAR-UHFFFAOYSA-N |
| SMILES | COc1ccc(OCC2c3cc(OC)c(OC)cc3CCN2C(=O)c2cccc(Cl)c2)cc1 |
| Storage condition | 2-8℃ |
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Name: Positive allosteric modulation of recombinant rat GluN1a/GluN2D receptor expressed in...
Source: ChEMBL
Target: Glutamate receptor ionotropic, NMDA 2D
External Id: CHEMBL4630125
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Name: Positive allosteric modulation of GluN2C receptor (unknown origin) expressed in xenop...
Source: ChEMBL
Target: Glutamate receptor ionotropic, NMDA 2C
External Id: CHEMBL4309011
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Name: Positive allosteric modulation of recombinant rat GluN1a/GluN2C receptor expressed in...
Source: ChEMBL
Target: Glutamate receptor ionotropic, NMDA 1
External Id: CHEMBL4630124
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Name: Activity at rat recombinant GluA1 receptor expressed in Xenopus oocytes assessed as e...
Source: ChEMBL
Target: Glutamate receptor 1
External Id: CHEMBL2399807
|
|
Name: Activity at rat recombinant GluK2 receptor expressed in Xenopus oocytes assessed as e...
Source: ChEMBL
Target: Glutamate receptor ionotropic, kainate 2
External Id: CHEMBL2399806
|
|
Name: Activity at rat recombinant GluN1/GluN2D receptor expressed in Xenopus oocytes assess...
Source: ChEMBL
Target: Glutamate receptor ionotropic, NMDA 2D
External Id: CHEMBL2400421
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Name: Enzymatic assay of human HDAC6 with commercial peptide substrate
Source: ChEMBL
Target: Histone deacetylase 6
External Id: CHEMBL4808149
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Name: Enzymatic assay of human HDAC6 with custom peptide substrate
Source: ChEMBL
Target: Histone deacetylase 6
External Id: CHEMBL4808150
|
|
Name: Dicer-mediated maturation of pre-microRNA
Source: Center for Chemical Genomics, University of Michigan
Target: N/A
External Id: TargetID_659_CEMA
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Name: Positive allosteric modulation of GluN2B receptor (unknown origin) expressed in xenop...
Source: ChEMBL
Target: Glutamate receptor ionotropic, NMDA 2B
External Id: CHEMBL4309010
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| (3-Chlorophenyl){6,7-dimethoxy-1-[(4-methoxyphenoxy)methyl]-3,4-dihydro-2(1H)-isoquinolinyl}methanone |
| Altanserin hydrochloride |
| CIQ |