Porphobilinogen

Modify Date: 2024-01-02 03:55:56

Porphobilinogen Structure
Porphobilinogen structure
Common Name Porphobilinogen
CAS Number 487-90-1 Molecular Weight 226.22900
Density 1.421g/cm3 Boiling Point 478.6ºC at 760 mmHg
Molecular Formula C10H14N2O4 Melting Point 174-177ºC
MSDS Chinese USA Flash Point 243.2ºC
Symbol GHS07
GHS07
Signal Word Warning

 Use of Porphobilinogen


Porphobilinogen could act as a phototoxin, a neurotoxin, and a metabotoxin.

 Names

Name porphobilinogen
Synonym More Synonyms

 Porphobilinogen Biological Activity

Description Porphobilinogen could act as a phototoxin, a neurotoxin, and a metabotoxin.
Related Catalog
Target

Human Endogenous Metabolite

In Vitro Porphobilinogen can act as a phototoxin, a neurotoxin, and a metabotoxin. A phototoxin leads to cell damage upon exposure to light. A neurotoxin causes damage to nerve cells and nerve tissues. A metabotoxin is an endogenously produced metabolite that causes adverse health effects at chronically high levels[1].
References

[1]. Winkelman JW, et al. Neurotoxicity of tetraphenylporphinesulfonate TPPS4 and its relation to photodynamic therapy. Photochem Photobiol. 1987 Nov;46(5):801-7.

 Chemical & Physical Properties

Density 1.421g/cm3
Boiling Point 478.6ºC at 760 mmHg
Melting Point 174-177ºC
Molecular Formula C10H14N2O4
Molecular Weight 226.22900
Flash Point 243.2ºC
Exact Mass 226.09500
PSA 116.41000
LogP 0.81800
Vapour Pressure 5.74E-10mmHg at 25°C
Index of Refraction 1.621
Storage condition -20°C

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi
Risk Phrases 36/37/38
Safety Phrases 26-36
RIDADR NONH for all modes of transport
HS Code 2933990090

 Synthetic Route

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles39

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Inactivation of the ubiquitin-specific protease 19 deubiquitinating enzyme protects against muscle wasting.

FASEB J. 29 , 3889-98, (2015)

The ubiquitin system plays a critical role in muscle wasting. Previous work has focused on the roles of ubiquitination. However, a role for deubiquitination in this process has not been established. B...

Mass spectrometric characterisation of a condensation product between porphobilinogen and indolyl-3-acryloylglycine in urine of patients with acute intermittent porphyria.

J. Mass Spectrom. 50 , 929-37, (2015)

We document the presence of a previously unknown species in the urine of patients with acute intermittent porphyria (AIP). The compound was fully characterised by liquid chromatography tandem mass spe...

Crosstalk between the mesothelium and lymphomatous cells: insight into the mechanisms involved in the progression of body cavity lymphomas.

Cancer Med. 3(1) , 1-13, (2014)

The peculiar localization of body cavity lymphomas implies a specific contribution of the intracavitary microenvironment to the pathogenesis of these tumors. In this study, primary effusion lymphoma (...

 Synonyms

EINECS 207-666-3
5-(Aminomethyl)-4-(carboxymethyl)-1H-pyrrole-3-propanoic acid
3-[5-(aminomethyl)-4-(carboxymethyl)-1H-pyrrol-3-yl]propanoic acid
Porphobilinogen
MFCD00005224
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