Glycine-d2

Modify Date: 2024-01-02 23:20:48

Glycine-d2 structure	Common Name	Glycine-d2
	CAS Number	4896-75-7	Molecular Weight	77.079
	Density	1.3±0.1 g/cm3	Boiling Point	240.9±23.0 °C at 760 mmHg
	Molecular Formula	C₂H₃D₂NO₂	Melting Point	240ºC (dec.)(lit.)
	MSDS	Chinese USA	Flash Point	99.5±22.6 °C

Use of Glycine-d2

Glycine-d2 is the deuterium labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.

Name	2-amino-2,2-dideuterioacetic acid
Synonym	More Synonyms

Description	Glycine-d2 is the deuterium labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

Density	1.3±0.1 g/cm3
Boiling Point	240.9±23.0 °C at 760 mmHg
Melting Point	240ºC (dec.)(lit.)
Molecular Formula	C₂H₃D₂NO₂
Molecular Weight	77.079
Flash Point	99.5±22.6 °C
Exact Mass	77.044579
PSA	63.32000
LogP	-1.03
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.461
Storage condition	2-8°C

Glycine-d2 MSDS(Chinese)

RIDADR	NONH for all modes of transport

Glycine

CAS#:56-40-6

~97%

Glycine-d2

CAS#:4896-75-7

Literature: Mitulovi, Goran; Laemmerhofer, Michael; Maier; Lindner, Wolfgang Journal of Labelled Compounds and Radiopharmaceuticals, 2000 , vol. 43, # 5 p. 449 - 461

Glyoxylic acid

CAS#:298-12-4

Glycine-d2

CAS#:4896-75-7

Literature: Hellerstein, Marc K. Patent: US2003/228259 A1, 2003 ; Location in patent: Page 4 ;

(RS)-serine-2-d

CAS#:53170-89-1

Glycine-d2

CAS#:4896-75-7

Literature: Hellerstein, Marc K. Patent: US2003/228259 A1, 2003 ; Location in patent: Page 4 ;

Precursor 2
CAS#:56-40-6 Glycine CAS#:298-12-4 Glyoxylic acid
DownStream 3
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