Glycine-d2

Modify Date: 2024-01-02 23:20:48

Glycine-d2 Structure
Glycine-d2 structure
Common Name Glycine-d2
CAS Number 4896-75-7 Molecular Weight 77.079
Density 1.3±0.1 g/cm3 Boiling Point 240.9±23.0 °C at 760 mmHg
Molecular Formula C2H3D2NO2 Melting Point 240ºC (dec.)(lit.)
MSDS Chinese USA Flash Point 99.5±22.6 °C

 Use of Glycine-d2


Glycine-d2 is the deuterium labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.

 Names

Name 2-amino-2,2-dideuterioacetic acid
Synonym More Synonyms

 Glycine-d2 Biological Activity

Description Glycine-d2 is the deuterium labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 240.9±23.0 °C at 760 mmHg
Melting Point 240ºC (dec.)(lit.)
Molecular Formula C2H3D2NO2
Molecular Weight 77.079
Flash Point 99.5±22.6 °C
Exact Mass 77.044579
PSA 63.32000
LogP -1.03
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.461
Storage condition 2-8°C

 Safety Information

RIDADR NONH for all modes of transport

 Synthetic Route

~97%

Glycine-d2 Structure

Glycine-d2

CAS#:4896-75-7

Literature: Mitulovi, Goran; Laemmerhofer, Michael; Maier; Lindner, Wolfgang Journal of Labelled Compounds and Radiopharmaceuticals, 2000 , vol. 43, # 5 p. 449 - 461

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Glycine-d2 Structure

Glycine-d2

CAS#:4896-75-7

Literature: Hellerstein, Marc K. Patent: US2003/228259 A1, 2003 ; Location in patent: Page 4 ;

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Glycine-d2 Structure

Glycine-d2

CAS#:4896-75-7

Literature: Hellerstein, Marc K. Patent: US2003/228259 A1, 2003 ; Location in patent: Page 4 ;

 Synonyms

2,2-2H2>glycine-2,2-d2
Glycine-2,2-d2
<2-2H2>glycine
(2,2-H)Glycine
MFCD00075077
Glycine-d2
Glycine-2,2-d