5-Hydroxyfisetin

Modify Date: 2025-08-23 17:29:04

5-Hydroxyfisetin structure	Common Name	5-Hydroxyfisetin
	CAS Number	490-31-3	Molecular Weight	302.236
	Density	1.8±0.1 g/cm3	Boiling Point	669.9±55.0 °C at 760 mmHg
	Molecular Formula	C₁₅H₁₀O₇	Melting Point	326-328ºC
	MSDS	N/A	Flash Point	258.6±25.0 °C

Use of 5-Hydroxyfisetin

Robinetin (3,3',4',5',7-Pentahydroxyflavone), a naturally occurring flavonoid with remarkable ‘two color’ intrinsic fluorescence properties, has antifungal, antiviral, antibacterial, antimutagenesis, and antioxidant activity. Robinetin also can inhibit lipid peroxidation and protein glycosylation[1][2][3][4][5].

Name	robinetin
Synonym	More Synonyms

Description	Robinetin (3,3',4',5',7-Pentahydroxyflavone), a naturally occurring flavonoid with remarkable ‘two color’ intrinsic fluorescence properties, has antifungal, antiviral, antibacterial, antimutagenesis, and antioxidant activity. Robinetin also can inhibit lipid peroxidation and protein glycosylation[1][2][3][4][5].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal Signaling Pathways >> Metabolic Enzyme/Protease >> HIV Integrase Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Robinetin (0.1-10 μM; 1 h) inhibits HIV integrase cleavage and integration in a dose-dependent manner[1]. Robinetin inhibits the DNA synthesis in Proteus vulgaris, and the RNA synthesis in S. aureus[2]. Robinetin (100-200 or 25 μM; 1 or 72 h) inhibits egg yolk phosphatidylcholine (EYPC) membrane lipid peroxidation and hemoglobin A (HbA) glycosylation with high efficiency[3]. Robinetin exhibits photo-induced excited-state intramolecular proton transfer resulting in ‘two color’ (in ‘blue-violet’ and ‘yellow-green’ regions) fluorescence characteristic of flavonols, the relative contributions between the two colors being strongly modulated by the local environment of the fluorophore[3].
References	[1]. Fesen MR, et, al. Inhibition of HIV-1 integrase by flavones, caffeic acid phenethyl ester (CAPE) and related compounds. Biochem Pharmacol. 1994 Aug 3;48(3):595-608. [2]. Cushnie TPT, et, al. Antimicrobial activity of flavonoids. Int J Antimicrob Agents. 2005 Nov;26(5):343-56. [3]. Chaudhuri S, et, al. Binding of the bioflavonoid robinetin with model membranes and hemoglobin: Inhibition of lipid peroxidation and protein glycosylation. J Photochem Photobiol B. 2010 Jan 21;98(1):12-9. [4]. Birt DF, et, al. Anti-mutagenesis and anti-promotion by apigenin, robinetin and indole-3-carbinol. Carcinogenesis. 1986 Jun;7(6):959-63. [5]. Manrique-de-la-Cuba MF, et, al. Theoretical study of the antioxidant capacity of the flavonoids present in the Annona muricata (Soursop) leaves. J Mol Model. 2019 Jun 25;25(7):200.

Density	1.8±0.1 g/cm3
Boiling Point	669.9±55.0 °C at 760 mmHg
Melting Point	326-328ºC
Molecular Formula	C₁₅H₁₀O₇
Molecular Weight	302.236
Flash Point	258.6±25.0 °C
Exact Mass	302.042664
PSA	131.36000
LogP	2.55
Vapour Pressure	0.0±2.2 mmHg at 25°C
Index of Refraction	1.823
InChIKey	SOEDEYVDCDYMMH-UHFFFAOYSA-N
SMILES	O=c1c(O)c(-c2cc(O)c(O)c(O)c2)oc2cc(O)ccc12

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LK8780000

CHEMICAL NAME :: Flavone, 3,3',4',5',7-pentahydroxy-

CAS REGISTRY NUMBER :: 490-31-3

BEILSTEIN REFERENCE NO. :: 0308905

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C15-H10-O7

MOLECULAR WEIGHT :: 302.25

WISWESSER LINE NOTATION :: T66 BO EVJ CR CQ DQ EQ& DQ IQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Microorganism - not otherwise specified

DOSE/DURATION :: 25 mg/L

REFERENCE :: PYTCAS Phytochemistry. An International Journal of Plant Biochemistry. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1961- Volume(issue)/page/year: 26,2231,1987

Hazard Codes	Xi
Risk Phrases	R22
Safety Phrases	22-45
RIDADR	UN 2811
HS Code	2932999099

Precursor 9
CAS#:354119-95-2 7-benzyloxy-3-h... CAS#:29682-12-0 1-(4-(Benzyloxy... CAS#:89-84-9 2,4-Dihydroxyac... CAS#:20979-43-5 7-Hydroxy-3,3',...
CAS#:57280-75-8 1-(2,4-DIFLUORO... CAS#:1719-88-6 Benzoic acid,3,... CAS#:132594-09-3 3,7-DIHYDROXY-3... CAS#:4382-33-6 3,3',4',5',7-Pe...
CAS#:109980-57-6 3-hydroxy-7-met...
DownStream 0

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Name: Inhibition of LPS/INF-gamma-stimulated nitric oxide production in mouse RAW264.7 cell...
Source: ChEMBL
Target: RAW264.7
External Id: CHEMBL3874800

Name: Antitrypanosomal activity against Trypanosoma brucei brucei Lister 427 bloodstream fo...
Source: ChEMBL
Target: Trypanosoma brucei brucei
External Id: CHEMBL4431996

Name: Antioxidant activity assessed as inhibition of DPPH radical production at 33 uM after...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3056854

Name: Inhibition of Trypanosoma brucei PTR1 at 50 uM using H2B as substrate incubated for 1...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4431999

Name: Inhibition of Leishmania mexicana DHFR at 50 uM using folic aid as substrate by spect...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4432001

Name: HIV Enzyme Data
Source: NIAID
Target: N/A
External Id: HIV Enzyme Data

Name: Inhibition of Avian myeloblastosis virus reverse transcriptase
Source: ChEMBL
Target: Polyprotein II
External Id: CHEMBL3047467

Name: HIV Cellular Data
Source: NIAID
Target: N/A
External Id: HIV Cellular Data

Name: Antioxidant activity assessed as DDPH radical scavenging activity
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL1225535

Name: Inhibition of Schistosoma mansoni recombinant NAD+ glycohydrolase expressed in Pichia...
Source: ChEMBL
Target: N/A
External Id: CHEMBL1285539

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Robinetin

Norkanugin

3,7,3',4',5'-pentahydroxyflavonol

3,7,3',4',5'-pentahydroxyflavone

3,7-Dihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chromen-4-one

3,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)chromen-4-one

5-Hydroxyfisetin

EINECS 207-709-6

3,3',4',5',7-Pentahydroxyflavone

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 5-Hydroxyfisetin
Price: Check
Purity: 96.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

BioBioPha
China
Product Name: Robinetin
Price: ￥1750.0/5mg
Purity: 96.0%
Delivery: 10 Day
Contact: Xueping-Zheng
Email: 1477035482@qq.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 5-Hydroxyfisetin
Price: ￥2560.0/5mg
Purity: 98.0%
Delivery: 3 Day
Contact: Liu jia
Email: 2130147988@qq.com

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