Nifuratel
Modify Date: 2024-01-02 11:16:35
Nifuratel structure
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Common Name | Nifuratel | ||
|---|---|---|---|---|
| CAS Number | 4936-47-4 | Molecular Weight | 285.276 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 423.6±53.0 °C at 760 mmHg | |
| Molecular Formula | C10H11N3O5S | Melting Point | 176-178°C | |
| MSDS | N/A | Flash Point | 210.0±30.9 °C | |
Use of NifuratelNifuratel(NF 113, SAP 113) is a broad antibacterial spectrum agent, which is used as an antibacterial, antifungal, and antiprotozoal (Trichomonas).IC50 Value: 0.125-1 μg/mL(MIC, A. vaginae) [1]Target: Antibacterial; Antiprotozoal in vitro: In vitro, nifuratel is able to inhibit the growth of A. vaginae, with a MIC range of 0.125-1 μg/mL; it is active against G. vaginalis and does not affect lactobacilli [1].in vivo: Patients were randomized to receive a 2-week course of bismuth subcitrate (8 mg/kg/day, q.d.s.), amoxicillin (50 mg/kg/day, q.d.s.), with either nifuratel (15 mg/kg/day, q.d.s.) or furazolidone (10 mg/kg/day, q.d.s.), plus omeprazole (0.5 mg/kg, once daily) [2].Toxicity: There were no serious adverse reactions and were no withdrawals due to any side-effects. All of side-effects were self-limiting (dark stools, urine discoloration, blackening of the tongue, and others) [3].Clinical trial: N/A |
| Name | Nifuratel |
|---|---|
| Synonym | More Synonyms |
| Description | Nifuratel(NF 113, SAP 113) is a broad antibacterial spectrum agent, which is used as an antibacterial, antifungal, and antiprotozoal (Trichomonas).IC50 Value: 0.125-1 μg/mL(MIC, A. vaginae) [1]Target: Antibacterial; Antiprotozoal in vitro: In vitro, nifuratel is able to inhibit the growth of A. vaginae, with a MIC range of 0.125-1 μg/mL; it is active against G. vaginalis and does not affect lactobacilli [1].in vivo: Patients were randomized to receive a 2-week course of bismuth subcitrate (8 mg/kg/day, q.d.s.), amoxicillin (50 mg/kg/day, q.d.s.), with either nifuratel (15 mg/kg/day, q.d.s.) or furazolidone (10 mg/kg/day, q.d.s.), plus omeprazole (0.5 mg/kg, once daily) [2].Toxicity: There were no serious adverse reactions and were no withdrawals due to any side-effects. All of side-effects were self-limiting (dark stools, urine discoloration, blackening of the tongue, and others) [3].Clinical trial: N/A |
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| Related Catalog | |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 423.6±53.0 °C at 760 mmHg |
| Melting Point | 176-178°C |
| Molecular Formula | C10H11N3O5S |
| Molecular Weight | 285.276 |
| Flash Point | 210.0±30.9 °C |
| Exact Mass | 285.041931 |
| PSA | 126.16000 |
| LogP | 0.27 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.666 |
| Storage condition | -20°C Freezer |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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| Hazard Codes | Xi |
|---|---|
| Risk Phrases | R36/37/38:Irritating to eyes, respiratory system and skin . |
| Safety Phrases | S26-S36-S37/39 |
| WGK Germany | 3 |
| 5-[(Methylthio)methyl]-3-[(5-nitrofurfurylidene)amino]-2-oxazolidinone |
| Polmiror |
| UNII:U60U6P08SP |
| nf113 |
| EINECS 225-576-2 |
| 5-[(Methylsulfanyl)methyl]-3-{(E)-[(5-nitro-2-furyl)methylene]amino}-1,3-oxazolidin-2-one |
| Magmilor |
| 5-(methylthiomethyl)-3-((5-nitrofuran-2-yl)methyleneamino)oxazolidin-2-one |
| Nifuratel |
| Methylmercadone |
| Tydantil |
| 2-Oxazolidinone, 5-((methylthio)methyl)-3-(((5-nitro-2-furanyl)methylene)amino)- |
| Macmiror |
| Omnes |
| MFCD00057257 |
| sap113 |
| 5-(Methylmercaptomethyl)-3-(5-nitro-2-furfurylideneamino)-2-oxazolidinone |
| 5-[(Methylthio)methyl]-3-[[(5-nitro-2-furanyl)methylene]amino]-2-oxazolidinone |
| Inimur |
| 2-Oxazolidinone, 5-[(methylthio)methyl]-3-[[(1E)-(5-nitro-2-furanyl)methylene]amino]- |
| 5-((Methylthio)methyl)-3-((5-nitrofurfurylidene)amino)-2-oxazolidinone |
| 5-[(Methylsulfanyl)methyl]-3-{[(E)-(5-nitro-2-furyl)methylene]amino}-1,3-oxazolidin-2-one |