Henan Tianfu Chemical Co., Ltd.
China
Product Name: Nifuratel
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Purity: 99.0%
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4936-47-4

4936-47-4 structure

Name: Nifuratel
Chemical Name: Nifuratel
CAS Number: 4936-47-4
Molecular Formula: C₁₀H₁₁N₃O₅S
Molecular Weight: 285.276
Catalog: API Synthetic anti-infective drugs Nitrofuran
Create Date: 2018-05-06 08:00:00
Modify Date: 2026-07-03 18:05:32
Nifuratel(NF 113, SAP 113) is a broad antibacterial spectrum agent, which is used as an antibacterial, antifungal, and antiprotozoal (Trichomonas).IC50 Value: 0.125-1 μg/mL(MIC, A. vaginae) [1]Target: Antibacterial; Antiprotozoal in vitro: In vitro, nifuratel is able to inhibit the growth of A. vaginae, with a MIC range of 0.125-1 μg/mL; it is active against G. vaginalis and does not affect lactobacilli [1].in vivo: Patients were randomized to receive a 2-week course of bismuth subcitrate (8 mg/kg/day, q.d.s.), amoxicillin (50 mg/kg/day, q.d.s.), with either nifuratel (15 mg/kg/day, q.d.s.) or furazolidone (10 mg/kg/day, q.d.s.), plus omeprazole (0.5 mg/kg, once daily) [2].Toxicity: There were no serious adverse reactions and were no withdrawals due to any side-effects. All of side-effects were self-limiting (dark stools, urine discoloration, blackening of the tongue, and others) [3].Clinical trial: N/A

Name	Nifuratel
Synonyms	Nifurtyl Polmiror 5-[(METHYLTHIO)METHYL]-3-[[(5-NITRO-2-FURANYL)METHYLENE]AMINO-]-2-OXAZO-LIDINONE 2-Oxazolidinone,5-[(Methylthio)Methyl]-3-[[(5-nitro-2-furanyl)Methylene]amino] Magmilor Nifuratel, 10 mM in DMSO 5-[(Methylsulfanyl)Methyl]-4-[(E)-[(5-nitrofuran-2-yl)Methylidene]amino]-1,3-oxazolidin-2-one 5-((methylthio)methyl)-3-((5-nitrofurfurylidine)amino)-2-oxazolidinon 5-(MethylMercaptoMethyl)-3-(5-nitro-2-furfurylidenaMino)-2-oxazolidinone 5-((methylthio)methyl)-3-((5-nitrofurfurylidine)amino)-2-oxazolidinone 5-(Methylsulfanylmethyl)-3-[(E)-(5-nitrofuran-2-yl)methylideneamino]-1,3-oxazolidin-2-one UNII:U60U6P08SP EINECS 225-576-2 5-[(Methylthio)methyl]-3-[[(5-nitro-2-furanyl)methylene]amino]-2-oxazolidinone, Methylmercadone, Inimur, Macmiror, Magmilor, Omnes, Polmiror, Tydantil MACMIROR 5-methylthiomethyl-3-(5-nitrofurfurylideneamino)-2-oxazolidone Tydantil omnes sap113 5-((Methylthio)methyl)-3-(((5-nitrofuran-2-yl)methylene)amino)oxazolidin-2-one 5-[(Methylthio)methyl]-3-[(5-nitrofurfurylidene)amino]-2-oxazolidinone Nifuratel powder Nifter 5-[(Methylsulfanyl)methyl]-3-{(E)-[(5-nitro-2-furyl)methylene]amino}-1,3-oxazolidin-2-one Methylmercadone NIFURATEL magmilor Omnes MFCD00057257 Nifuratel in Acetonitrile Inimur polmiror NIFURATEL (MACMIROR) nf113 Nitrofurateyr, Nitrofurateyr Nifurtal 5-(methylthiomethyl)-3-((5-nitrofuran-2-yl)methyleneamino)oxazolidin-2-one Nifuratel //BP Macmiror l’n-(5-nitro-2-furfurilidene)-3-amino-5-metilmercaptometil-2-ossazolidinone Nifurate Nimozole 5-(Methylmercaptomethyl)-3-(5-nitro-2-furfurylideneamino)-2-oxazolidinone 5-[(Methylthio)methyl]-3-[[(5-nitro-2-furanyl)methylene]amino]-2-oxazolidinone 5-[(methylthio)methyl]-3-[(Z)-(5-nitro-2-furanyl)methylideneamino]-2-oxazolidinone 3-[(5-Nitro-2-furfurylidene)amino]-5-[(Methylthio)Methyl]-2-oxazolidinone methylmercadone 5-((Methylthio)methyl)-3-((5-nitrofurfurylidene)amino)-2-oxazolidinone 5-[(Methylsulfanyl)methyl]-3-{[(E)-(5-nitro-2-furyl)methylene]amino}-1,3-oxazolidin-2-one

Description	Nifuratel(NF 113, SAP 113) is a broad antibacterial spectrum agent, which is used as an antibacterial, antifungal, and antiprotozoal (Trichomonas).IC50 Value: 0.125-1 μg/mL(MIC, A. vaginae) [1]Target: Antibacterial; Antiprotozoal in vitro: In vitro, nifuratel is able to inhibit the growth of A. vaginae, with a MIC range of 0.125-1 μg/mL; it is active against G. vaginalis and does not affect lactobacilli [1].in vivo: Patients were randomized to receive a 2-week course of bismuth subcitrate (8 mg/kg/day, q.d.s.), amoxicillin (50 mg/kg/day, q.d.s.), with either nifuratel (15 mg/kg/day, q.d.s.) or furazolidone (10 mg/kg/day, q.d.s.), plus omeprazole (0.5 mg/kg, once daily) [2].Toxicity: There were no serious adverse reactions and were no withdrawals due to any side-effects. All of side-effects were self-limiting (dark stools, urine discoloration, blackening of the tongue, and others) [3].Clinical trial: N/A
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Signaling Pathways >> Anti-infection >> Parasite Natural Products >> Alkaloid Research Areas >> Infection
References	[1]. Polatti F. Bacterial vaginosis, Atopobium vaginae and nifuratel. Curr Clin Pharmacol. 2012 Feb 1;7(1):36-40. [2]. Nijevitch AA, et al. Helicobacter pylori eradication in childhood after failure of initial treatment: advantage of quadruple therapy withnifuratel to furazolidone. Aliment Pharmacol Ther. 2005 Nov 1;22(9):881-7. [3]. Nijevitch AA, et al. Nifuratel-containing initial anti-Helicobacter pylori triple therapy in children. Helicobacter. 2007 Apr;12(2):132-5.

Density	1.6±0.1 g/cm3
Boiling Point	423.6±53.0 °C at 760 mmHg
Melting Point	176-178°C
Molecular Formula	C₁₀H₁₁N₃O₅S
Molecular Weight	285.276
Flash Point	210.0±30.9 °C
Exact Mass	285.041931
PSA	126.16000
LogP	0.27
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.666
Storage condition	-20°C Freezer

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RQ3590000

CHEMICAL NAME :: 2-Oxazolidinone, 5-((methylthio)methyl)-3-((5-nitrofurfurylidine)amino )-

CAS REGISTRY NUMBER :: 4936-47-4

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C10-H11-N3-O5-S

MOLECULAR WEIGHT :: 285.30

WISWESSER LINE NOTATION :: T5OJ BNW E1UN- AT5NVOTJ E1S1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >4500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 50 ng/plate

REFERENCE :: MIGIA6 Minerva Ginecologia. (Edizioni Minerva Medica, Casella Postale 491, I-10126 Turin, Italy) V.1- 1949- Volume(issue)/page/year: 31,263,1979

Hazard Codes	Xi
Risk Phrases	R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases	S26-S36-S37/39
WGK Germany	3

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