Methylsticin structure
|
Common Name | Methylsticin | ||
---|---|---|---|---|
CAS Number | 495-85-2 | Molecular Weight | 274.269 | |
Density | 1.3±0.1 g/cm3 | Boiling Point | 496.5±45.0 °C at 760 mmHg | |
Molecular Formula | C15H14O5 | Melting Point | 139-140.5ºC | |
MSDS | USA | Flash Point | 223.9±28.8 °C |
Use of MethylsticinMethylsticin is a kavalactone isolated from the kava roots. Methylsticin exhibit osteoclast formation inhibitory activity[1]. |
Name | (2R)-2-[(E)-2-(1,3-benzodioxol-5-yl)ethenyl]-4-methoxy-2,3-dihydropyran-6-one |
---|---|
Synonym | More Synonyms |
Description | Methylsticin is a kavalactone isolated from the kava roots. Methylsticin exhibit osteoclast formation inhibitory activity[1]. |
---|---|
Related Catalog | |
References |
[1]. Shoujun Chen, et al. Methods of inhibiting osteoclast activity. US20030229137A1. |
Density | 1.3±0.1 g/cm3 |
---|---|
Boiling Point | 496.5±45.0 °C at 760 mmHg |
Melting Point | 139-140.5ºC |
Molecular Formula | C15H14O5 |
Molecular Weight | 274.269 |
Flash Point | 223.9±28.8 °C |
Exact Mass | 274.084137 |
PSA | 53.99000 |
LogP | 1.81 |
Vapour Pressure | 0.0±1.3 mmHg at 25°C |
Index of Refraction | 1.597 |
Storage condition | 2-8°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
RIDADR | NONH for all modes of transport |
---|
~58% Methylsticin CAS#:495-85-2 |
Literature: Soldi, Cristian; Moro, Angelica V.; Pizzolatti, Moacir G.; Correia, Carlos R. D. European Journal of Organic Chemistry, 2012 , # 19 p. 3607 - 3616 |
~42% Methylsticin CAS#:495-85-2 |
Literature: Amaral, Patricia A.; Gouault, Nicolas; Roch, Myriam Le; Eifler-Lima, Vera L.; David, Michele Tetrahedron Letters, 2008 , vol. 49, # 47 p. 6607 - 6609 |
~% Methylsticin CAS#:495-85-2 |
Literature: Soldi, Cristian; Moro, Angelica V.; Pizzolatti, Moacir G.; Correia, Carlos R. D. European Journal of Organic Chemistry, 2012 , # 19 p. 3607 - 3616 |
~% Methylsticin CAS#:495-85-2 |
Literature: Ali Shaik, Ahmad; Tan, Jonathan; Lue, Junxuan; Xing, Chengguo Arkivoc, 2012 , vol. 2012, # 8 p. 137 - 145 |
~% Methylsticin CAS#:495-85-2 |
Literature: Ali Shaik, Ahmad; Tan, Jonathan; Lue, Junxuan; Xing, Chengguo Arkivoc, 2012 , vol. 2012, # 8 p. 137 - 145 |
~% Methylsticin CAS#:495-85-2 |
Literature: Klohs et al. Journal of Organic Chemistry, 1959 , vol. 24, p. 1829 |
Precursor 6 | |
---|---|
DownStream 4 | |
Fatal kavalactone intoxication by suicidal intravenous injection.
Forensic Sci. Int. 249 , e7-11, (2015) Kavalactones are a group of compounds found in kava, a beverage or extract prepared from the rhizome of the kava plant (Piper methysticum). Traditionally kava extracts have been used for their anxioly... |
|
Influence of genuine kavapyrone enantiomers on the GABA-A binding site.
Planta Med. 64(6) , 504-6, (1998) The influence of kavapyrones from Piper methysticum Forst. on the GABAA receptor was demonstrated using radioreceptor assays. Both the dienolide yangonin and the genuine enolide enantiomers (+)-kavain... |
|
Interaction of various Piper methysticum cultivars with CNS receptors in vitro.
Planta Med. 67(4) , 306-11, (2001) Methanolic leaf and root extracts of the Hawaiian kava (Piper methysticum Forst.) cultivars, Mahakea, Nene, Purple Moi and PNG, were tested on binding affinities to CNS receptors including GABAA (GABA... |
2H-Pyran-2-one, 6-[(E)-2-(1,3-benzodioxol-5-yl)ethenyl]-5,6-dihydro-4-methoxy-, (6S)- |
(E)-6-[2-(benzo[d][1,3]dioxol-5-yl)vinyl]-4-methoxy-5,6-dihydropyran-2-one |
2H-Pyran-2-one, 6-[(E)-2-(1,3-benzodioxol-5-yl)ethenyl]-5,6-dihydro-4-methoxy-, (6R)- |
(+-)-Methysticin |
(R-(E))-6-(2-(1,3-Benzodioxol-5-yl)ethenyl)-5,6-dihydro-4-methoxy-2H-pyran-2-one |
[R-(E)]-6-[2-(1,3-Benzodioxol-5-yl)ethenyl]-5,6-dihydro-4-methoxy-2H-pyran-2-one |
6-(3',4'-Methylenedioxystyryl)-4-methoxy-5,6-dihydro-2H-pyran-2-one |
Kavahin |
(6S)-6-[(E)-2-(1,3-Benzodioxol-5-yl)vinyl]-4-methoxy-5,6-dihydro-2H-pyran-2-one |
Methysticin |
4-Methoxy-6-[b-(3',4'-methylenedioxyphenyl)vinyl]-5,6-dihydro-a-pyrone |
(6R)-6-[(E)-2-(1,3-benzodioxol-5-yl)ethenyl]-4-methoxy-5,6-dihydro-2H-pyran-2-one |
5-Hydroxy-3-methoxy-7-[3,4-(methylenedioxy)phenyl]-2,6-heptadienoic Acid d-Lactone |
6-(2-benzo[1,3]dioxol-5-yl-vinyl)-4-methoxy-5,6-dihydro-pyran-2-one |
(E)-6-[2-(benzo[d][1,3]dioxol-5-yl)vinyl]-4-methoxy-5,6-dihydro-2H-pyran-2-one |
(R)-5,6-Dihydro-4-methoxy-6-(3,4-(methylenedioxy)styryl)-2H-pyran-2-one |
(6R)-6-[(E)-2-(1,3-Benzodioxol-5-yl)vinyl]-4-methoxy-5,6-dihydro-2H-pyran-2-one |
Kavatin |