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495-85-2

495-85-2 structure
495-85-2 structure
  • Name: Methylsticin
  • Chemical Name: (2R)-2-[(E)-2-(1,3-benzodioxol-5-yl)ethenyl]-4-methoxy-2,3-dihydropyran-6-one
  • CAS Number: 495-85-2
  • Molecular Formula: C15H14O5
  • Molecular Weight: 274.269
  • Catalog: analytical chemistry Standard Analytical standard
  • Create Date: 2018-07-05 10:49:32
  • Modify Date: 2024-01-02 23:23:03
  • Methylsticin is a kavalactone isolated from the kava roots. Methylsticin exhibit osteoclast formation inhibitory activity[1].
Name (2R)-2-[(E)-2-(1,3-benzodioxol-5-yl)ethenyl]-4-methoxy-2,3-dihydropyran-6-one
Synonyms 2H-Pyran-2-one, 6-[(E)-2-(1,3-benzodioxol-5-yl)ethenyl]-5,6-dihydro-4-methoxy-, (6S)-
(E)-6-[2-(benzo[d][1,3]dioxol-5-yl)vinyl]-4-methoxy-5,6-dihydropyran-2-one
2H-Pyran-2-one, 6-[(E)-2-(1,3-benzodioxol-5-yl)ethenyl]-5,6-dihydro-4-methoxy-, (6R)-
(+-)-Methysticin
(R-(E))-6-(2-(1,3-Benzodioxol-5-yl)ethenyl)-5,6-dihydro-4-methoxy-2H-pyran-2-one
[R-(E)]-6-[2-(1,3-Benzodioxol-5-yl)ethenyl]-5,6-dihydro-4-methoxy-2H-pyran-2-one
6-(3',4'-Methylenedioxystyryl)-4-methoxy-5,6-dihydro-2H-pyran-2-one
Kavahin
(6S)-6-[(E)-2-(1,3-Benzodioxol-5-yl)vinyl]-4-methoxy-5,6-dihydro-2H-pyran-2-one
Methysticin
4-Methoxy-6-[b-(3',4'-methylenedioxyphenyl)vinyl]-5,6-dihydro-a-pyrone
(6R)-6-[(E)-2-(1,3-benzodioxol-5-yl)ethenyl]-4-methoxy-5,6-dihydro-2H-pyran-2-one
5-Hydroxy-3-methoxy-7-[3,4-(methylenedioxy)phenyl]-2,6-heptadienoic Acid d-Lactone
6-(2-benzo[1,3]dioxol-5-yl-vinyl)-4-methoxy-5,6-dihydro-pyran-2-one
(E)-6-[2-(benzo[d][1,3]dioxol-5-yl)vinyl]-4-methoxy-5,6-dihydro-2H-pyran-2-one
(R)-5,6-Dihydro-4-methoxy-6-(3,4-(methylenedioxy)styryl)-2H-pyran-2-one
(6R)-6-[(E)-2-(1,3-Benzodioxol-5-yl)vinyl]-4-methoxy-5,6-dihydro-2H-pyran-2-one
Kavatin
Description Methylsticin is a kavalactone isolated from the kava roots. Methylsticin exhibit osteoclast formation inhibitory activity[1].
Related Catalog
References

[1]. Shoujun Chen, et al. Methods of inhibiting osteoclast activity. US20030229137A1.
Density 1.3±0.1 g/cm3
Boiling Point 496.5±45.0 °C at 760 mmHg
Melting Point 139-140.5ºC
Molecular Formula C15H14O5
Molecular Weight 274.269
Flash Point 223.9±28.8 °C
Exact Mass 274.084137
PSA 53.99000
LogP 1.81
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.597
Storage condition 2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UQ0517000
CHEMICAL NAME :
2H-Pyran-2-one, 5,6-dihydro-4-methoxy-6-(3,4-(methylenedioxy)styryl)- , (R)-
CAS REGISTRY NUMBER :
495-85-2
BEILSTEIN REFERENCE NO. :
0091701
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C15-H14-O5
MOLECULAR WEIGHT :
274.29
WISWESSER LINE NOTATION :
T56 BO DO CHJ G1U1- FT6OV CUTJ DO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
530 mg/kg
TOXIC EFFECTS :
Behavioral - anticonvulsant
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 177,261,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
49 mg/kg
TOXIC EFFECTS :
Behavioral - anticonvulsant
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 177,261,1969
RIDADR NONH for all modes of transport
1092383-57-7 structure

1092383-57-7
1682-37-7 structure

1682-37-7

~58%

495-85-2 structure

495-85-2
Literature: Soldi, Cristian; Moro, Angelica V.; Pizzolatti, Moacir G.; Correia, Carlos R. D. European Journal of Organic Chemistry, 2012 , # 19 p. 3607 - 3616
1092383-57-7 structure

1092383-57-7
5876-51-7 structure

5876-51-7

~42%

495-85-2 structure

495-85-2
Literature: Amaral, Patricia A.; Gouault, Nicolas; Roch, Myriam Le; Eifler-Lima, Vera L.; David, Michele Tetrahedron Letters, 2008 , vol. 49, # 47 p. 6607 - 6609
117081-50-2 structure

117081-50-2

~%

495-85-2 structure

495-85-2
Literature: Soldi, Cristian; Moro, Angelica V.; Pizzolatti, Moacir G.; Correia, Carlos R. D. European Journal of Organic Chemistry, 2012 , # 19 p. 3607 - 3616
120-57-0 structure

120-57-0

~%

495-85-2 structure

495-85-2
Literature: Ali Shaik, Ahmad; Tan, Jonathan; Lue, Junxuan; Xing, Chengguo Arkivoc, 2012 , vol. 2012, # 8 p. 137 - 145
58095-77-5 structure

58095-77-5

~%

495-85-2 structure

495-85-2
Literature: Ali Shaik, Ahmad; Tan, Jonathan; Lue, Junxuan; Xing, Chengguo Arkivoc, 2012 , vol. 2012, # 8 p. 137 - 145
26536-93-6 structure

26536-93-6
58095-77-5 structure

58095-77-5

~%

495-85-2 structure

495-85-2
Literature: Klohs et al. Journal of Organic Chemistry, 1959 , vol. 24, p. 1829

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title: CAS No. 495-85-2 | Chemsrc address: https://m.chemsrc.com/en/baike/678443.html

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