Rimexolone
Rimexolone structure
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Common Name | Rimexolone | ||
|---|---|---|---|---|
| CAS Number | 49697-38-3 | Molecular Weight | 370.525 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 507.0±50.0 °C at 760 mmHg | |
| Molecular Formula | C24H34O3 | Melting Point | 258-268ºC | |
| MSDS | N/A | Flash Point | 274.5±26.6 °C | |
Use of RimexoloneRimexolone (Org 6216) is a glucocorticoid steroid with anti-inflammatory activity. Rimexolone can be used as a 1% ophthalmic suspension for the management of ocular inflammation[1][2]. |
| Name | Rimexolone |
|---|---|
| Synonym | More Synonyms |
| Description | Rimexolone (Org 6216) is a glucocorticoid steroid with anti-inflammatory activity. Rimexolone can be used as a 1% ophthalmic suspension for the management of ocular inflammation[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | Rimexolone (Org 6216) shows highly enhanced persistence at the injection site, minimal systematic effects and virtually does not induce skin artrophy[1]. |
| In Vivo | Rimexolone (Org 6216) (0-450 μg/mouse; intraarticular injection; once) shows prolonged anti-inflammatory action in mice with monoarticular antigen-induced arthritis[1]. Animal Model: Male, 8-12 weeks old C57Black/6 mice with antigen induced arthritis[1] Dosage: 5, 25, 50, 150, 250, 450 μg/mouse Administration: Intraarticular injection, once Result: Suppressed the arthritis in a dose-dependent manner. Significantly prevented osteophyte formation at 450 and 150 μg. Resulted in a decrease of the inhibition of the chondrocyte proteoglycan synthesis. |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 507.0±50.0 °C at 760 mmHg |
| Melting Point | 258-268ºC |
| Molecular Formula | C24H34O3 |
| Molecular Weight | 370.525 |
| Flash Point | 274.5±26.6 °C |
| Exact Mass | 370.250793 |
| PSA | 54.37000 |
| LogP | 4.01 |
| Vapour Pressure | 0.0±3.0 mmHg at 25°C |
| Index of Refraction | 1.559 |
| InChIKey | QTTRZHGPGKRAFB-OOKHYKNYSA-N |
| SMILES | CCC(=O)C1(C)C(C)CC2C3CCC4=CC(=O)C=CC4(C)C3C(O)CC21C |
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Rimexolone CAS#:49697-38-3 |
| Literature: Conrow, Raymond E. Journal of Organic Chemistry, 1999 , vol. 64, # 3 p. 1042 - 1044 |
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Rimexolone CAS#:49697-38-3 |
| Literature: Conrow, Raymond E. Journal of Organic Chemistry, 1999 , vol. 64, # 3 p. 1042 - 1044 |
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Rimexolone CAS#:49697-38-3 |
| Literature: Conrow, Raymond E. Journal of Organic Chemistry, 1999 , vol. 64, # 3 p. 1042 - 1044 |
|
~%
Rimexolone CAS#:49697-38-3 |
| Literature: Conrow, Raymond E. Journal of Organic Chemistry, 1999 , vol. 64, # 3 p. 1042 - 1044 |
|
~%
Rimexolone CAS#:49697-38-3 |
| Literature: Conrow, Raymond E. Journal of Organic Chemistry, 1999 , vol. 64, # 3 p. 1042 - 1044 |
|
~%
Rimexolone CAS#:49697-38-3 |
| Literature: Conrow, Raymond E. Journal of Organic Chemistry, 1999 , vol. 64, # 3 p. 1042 - 1044 |
|
~%
Rimexolone CAS#:49697-38-3 |
| Literature: Conrow, Raymond E. Journal of Organic Chemistry, 1999 , vol. 64, # 3 p. 1042 - 1044 |
|
~%
Rimexolone CAS#:49697-38-3 |
| Literature: Conrow, Raymond E. Journal of Organic Chemistry, 1999 , vol. 64, # 3 p. 1042 - 1044 |
|
~%
Rimexolone CAS#:49697-38-3 |
| Literature: Conrow, Raymond E. Journal of Organic Chemistry, 1999 , vol. 64, # 3 p. 1042 - 1044 |
![(8S,9S,10S,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-iodoacetyl)-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one structure](https://image.chemsrc.com/caspic/354/49757-06-4.png)
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Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
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Name: Dicer-mediated maturation of pre-microRNA
Source: Center for Chemical Genomics, University of Michigan
Target: N/A
External Id: TargetID_659_CEMA
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN
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|
Name: Fluorescence polarization-based biochemical high throughput primary assay to identify...
Source: The Scripps Research Institute Molecular Screening Center
Target: RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens]
External Id: SIAE_INH_FP_1536_1X%INH PRUN
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Name: MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Activator_SinglePoint...
Source: Broad Institute
Target: N/A
External Id: 2084-01_Activator_SinglePoint_HTS_Activity
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Name: Counterscreen for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberc...
Source: The Scripps Research Institute Molecular Screening Center
Target: N/A
External Id: GDH-TPI_INH_ABS_1536_1X%INH CSRUN
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Name: Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL4303805
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Name: Inhibition of cell viability relative to arbidol control (inhibition index > 1 indica...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL4303819
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Name: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen
Source: NCGC
Target: N/A
External Id: SMAD3201
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| Rimexolone |
| (11β,16α,17β)-11-Hydroxy-16,17-dimethyl-17-(1-oxopropyl)androsta-1,4-dien-3-one |
| 11β-Hydroxy-16α,17α-dimethyl-17-propionylandrosta-1,4-dien-3-one |
| 11b-Hydroxy-16a,17a-dimethyl-17-propionylandrosta-1,4-dien-3-one |
| (8S,9S,10R,11S,13S,14S,16R,17S)-11-Hydroxy-10,13,16,17-tetramethyl-17-propionyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one |
| (8S,9S,10R,11S,13S,14S,16R,17S)-11-Hydroxy-10,13,16,17-tetramethyl-17-propanoyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-on |
| (8S,9S,10R,11S,13S,14S,16R,17S)-11-hydroxy-10,13,16,17-tetramethyl-17-propanoyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one |
| (11b,16a,17b)-11-Hydroxy-16,17-dimethyl-17-(1-oxopropyl)androsta-1,4-dien-3-one |
| Asoprisnil ecamate |
| (8S,9S,10R,11S,13S,14S,16R,17S)-11-hydroxy-10,13,16,17-tétraméthyl-17-propanoyl-6,7,8,9,10,11,12,13,14,15,16,17-dodécahydro-3H-cyclopenta[a]phénanthrén-3-one |
| 11β-Hydroxy-16α,17,21-trimethyl-1,4-pregnadien-3,20-dion |
| (8S,9S,10R,11S,13S,14S,16R,17S)-11-hydroxy-10,13,16,17-tetramethyl-17-propanoyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one (non-preferred name) |
| (8S,9S,10R,13S,14S,16R,17S)-11-Hydroxy-10,13,16,17-tetramethyl-17-propionyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one (non-preferred name) |
| VEXOL |