Rimexolone

Modify Date: 2025-08-26 21:00:14

Rimexolone structure	Common Name	Rimexolone
	CAS Number	49697-38-3	Molecular Weight	370.525
	Density	1.1±0.1 g/cm3	Boiling Point	507.0±50.0 °C at 760 mmHg
	Molecular Formula	C₂₄H₃₄O₃	Melting Point	258-268ºC
	MSDS	N/A	Flash Point	274.5±26.6 °C

Use of Rimexolone

Rimexolone (Org 6216) is a glucocorticoid steroid with anti-inflammatory activity. Rimexolone can be used as a 1% ophthalmic suspension for the management of ocular inflammation[1][2].

Name	Rimexolone
Synonym	More Synonyms

Description	Rimexolone (Org 6216) is a glucocorticoid steroid with anti-inflammatory activity. Rimexolone can be used as a 1% ophthalmic suspension for the management of ocular inflammation[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vitro	Rimexolone (Org 6216) shows highly enhanced persistence at the injection site, minimal systematic effects and virtually does not induce skin artrophy[1].
In Vivo	Rimexolone (Org 6216) (0-450 μg/mouse; intraarticular injection; once) shows prolonged anti-inflammatory action in mice with monoarticular antigen-induced arthritis[1]. Animal Model: Male, 8-12 weeks old C57Black/6 mice with antigen induced arthritis[1] Dosage: 5, 25, 50, 150, 250, 450 μg/mouse Administration: Intraarticular injection, once Result: Suppressed the arthritis in a dose-dependent manner. Significantly prevented osteophyte formation at 450 and 150 μg. Resulted in a decrease of the inhibition of the chondrocyte proteoglycan synthesis.
References	[1]. Joosten LA, et al. Protective effect of rimexolone on cartilage damage in arthritic mice: a comparative study with triamcinolone hexacetonide. Agents Actions. 1990 Aug;31(1-2):135-42. [2]. Foster CS, et al. Efficacy and safety of rimexolone 1% ophthalmic suspension vs 1% prednisolone acetate in the treatment of uveitis. Am J Ophthalmol. 1996 Aug;122(2):171-82.

Density	1.1±0.1 g/cm3
Boiling Point	507.0±50.0 °C at 760 mmHg
Melting Point	258-268ºC
Molecular Formula	C₂₄H₃₄O₃
Molecular Weight	370.525
Flash Point	274.5±26.6 °C
Exact Mass	370.250793
PSA	54.37000
LogP	4.01
Vapour Pressure	0.0±3.0 mmHg at 25°C
Index of Refraction	1.559

11β-(trimethyls...

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~97%

Rimexolone

CAS#:49697-38-3

Literature: Conrow, Raymond E. Journal of Organic Chemistry, 1999 , vol. 64, # 3 p. 1042 - 1044

prednisolone

CAS#:50-24-8

Rimexolone

CAS#:49697-38-3

Literature: Conrow, Raymond E. Journal of Organic Chemistry, 1999 , vol. 64, # 3 p. 1042 - 1044

(8S,9S,10S,11S,...

CAS#:49757-06-4

Rimexolone

CAS#:49697-38-3

Literature: Conrow, Raymond E. Journal of Organic Chemistry, 1999 , vol. 64, # 3 p. 1042 - 1044

11β,17-dihydrox...

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Rimexolone

CAS#:49697-38-3

Literature: Conrow, Raymond E. Journal of Organic Chemistry, 1999 , vol. 64, # 3 p. 1042 - 1044

Deprodone

CAS#:20423-99-8

Rimexolone

CAS#:49697-38-3

Literature: Conrow, Raymond E. Journal of Organic Chemistry, 1999 , vol. 64, # 3 p. 1042 - 1044

11β-hydroxypreg...

CAS#:60124-50-7

Rimexolone

CAS#:49697-38-3

Literature: Conrow, Raymond E. Journal of Organic Chemistry, 1999 , vol. 64, # 3 p. 1042 - 1044

11β-(trimethyls...

CAS#:60124-51-8

Rimexolone

CAS#:49697-38-3

Literature: Conrow, Raymond E. Journal of Organic Chemistry, 1999 , vol. 64, # 3 p. 1042 - 1044

21-methyl-11β-(...

CAS#:207346-24-5

Rimexolone

CAS#:49697-38-3

Literature: Conrow, Raymond E. Journal of Organic Chemistry, 1999 , vol. 64, # 3 p. 1042 - 1044

N/A

CAS#:226712-41-0

Rimexolone

CAS#:49697-38-3

Literature: Conrow, Raymond E. Journal of Organic Chemistry, 1999 , vol. 64, # 3 p. 1042 - 1044

Rimexolone

(11β,16α,17β)-11-Hydroxy-16,17-dimethyl-17-(1-oxopropyl)androsta-1,4-dien-3-one

11β-Hydroxy-16α,17α-dimethyl-17-propionylandrosta-1,4-dien-3-one

11b-Hydroxy-16a,17a-dimethyl-17-propionylandrosta-1,4-dien-3-one

(8S,9S,10R,11S,13S,14S,16R,17S)-11-Hydroxy-10,13,16,17-tetramethyl-17-propionyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one

(8S,9S,10R,11S,13S,14S,16R,17S)-11-Hydroxy-10,13,16,17-tetramethyl-17-propanoyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-on

(8S,9S,10R,11S,13S,14S,16R,17S)-11-hydroxy-10,13,16,17-tetramethyl-17-propanoyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one

(11b,16a,17b)-11-Hydroxy-16,17-dimethyl-17-(1-oxopropyl)androsta-1,4-dien-3-one

Asoprisnil ecamate

Androsta-1,4-dien-3-one, 11-hydroxy-16,17-dimethyl-17-(1-oxopropyl)-, (11β,16α,17β)-

(8S,9S,10R,11S,13S,14S,16R,17S)-11-hydroxy-10,13,16,17-tétraméthyl-17-propanoyl-6,7,8,9,10,11,12,13,14,15,16,17-dodécahydro-3H-cyclopenta[a]phénanthrén-3-one

11β-Hydroxy-16α,17,21-trimethyl-1,4-pregnadien-3,20-dion

(8S,9S,10R,11S,13S,14S,16R,17S)-11-hydroxy-10,13,16,17-tetramethyl-17-propanoyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one (non-preferred name)

(8S,9S,10R,13S,14S,16R,17S)-11-Hydroxy-10,13,16,17-tetramethyl-17-propionyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one (non-preferred name)

VEXOL

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