Goitrin

Modify Date: 2024-01-31 21:08:39

Goitrin Structure
Goitrin structure
Common Name Goitrin
CAS Number 500-12-9 Molecular Weight 129.18000
Density N/A Boiling Point N/A
Molecular Formula C5H7NOS Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Goitrin


Goitrin ((S)-Goitrin), a product of glucosinolate-myrosinase reactions, is a potent inhibitor of thyroid peroxidase. Goitrin can inhibit iodine utilization by the thyroid. Goitrin also exhibits anti-influenza virus (H1N1) activity[1][2][3].

 Names

Name (5S)-5-vinyl-1,3-oxazolidine-2-thione
Synonym More Synonyms

 Goitrin Biological Activity

Description Goitrin ((S)-Goitrin), a product of glucosinolate-myrosinase reactions, is a potent inhibitor of thyroid peroxidase. Goitrin can inhibit iodine utilization by the thyroid. Goitrin also exhibits anti-influenza virus (H1N1) activity[1][2][3].
Related Catalog
In Vitro Goitrin (0.1-1 μM; 72 h) exhibits dose-dependent anti-influenza virus (H1N1) activity in Madin-Darby canine kidney (MDCK) cells, with an IC50 of 0.19 μM[3].
References

[1]. Felker P, et, al. Concentrations of thiocyanate and goitrin in human plasma, their precursor concentrations in brassica vegetables, and associated potential risk for hypothyroidism. Nutr Rev. 2016 Apr;74(4):248-58.

[2]. Wooding S, et, al. Genetics and bitter taste responses to goitrin, a plant toxin found in vegetables. Chem Senses. 2010 Oct;35(8):685-92.

[3]. Nie LX, et, al. Antiviral activity of Isatidis Radix derived glucosinolate isomers and their breakdown products against influenza A in vitro/ovo and mechanism of action. J Ethnopharmacol. 2020 Apr 6;251:112550.

 Chemical & Physical Properties

Molecular Formula C5H7NOS
Molecular Weight 129.18000
Exact Mass 129.02500
PSA 53.35000
LogP 0.77450

 Safety Information

Hazard Codes Xi
Safety Phrases S24/25

 Synonyms

D,L-GOITRIN
S-goitrin
(S)-5-vinyl-oxazolidine-2-thione
(S)-5-Vinyl-oxazolidin-2-thion
goitrin
MFCD00015467