BL-1020
Modify Date: 2024-01-10 19:47:33
BL-1020 structure
|
Common Name | BL-1020 | ||
|---|---|---|---|---|
| CAS Number | 503537-33-5 | Molecular Weight | 489.073 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 635.6±55.0 °C at 760 mmHg | |
| Molecular Formula | C25H34Cl2N4O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 338.2±31.5 °C | |
Use of BL-1020BL-1020 is an ester of GABA and perphenazine, fuctions as orally-active antipsychotic agent and acts as a D2 antagonist and GABA agonist; reduces dopamine activity and enhances GABAA activity, shows pro-cognitive effects and potential for the treatment of schizophrenia; displays strong dopamine and serotonin (5HT) receptor inhibition ((D2LK(iz)=0.066 nM, D(2S)Ki=0.062 nM, 5-HT2A Ki=0.21 nM). Schizophrenia Phase 2 Discontinued |
| Name | PERPHENAZINE 4-AMINOBUTYRATE |
|---|---|
| Synonym | More Synonyms |
| Description | BL-1020 is an ester of GABA and perphenazine, fuctions as orally-active antipsychotic agent and acts as a D2 antagonist and GABA agonist; reduces dopamine activity and enhances GABAA activity, shows pro-cognitive effects and potential for the treatment of schizophrenia; displays strong dopamine and serotonin (5HT) receptor inhibition ((D2LK(iz)=0.066 nM, D(2S)Ki=0.062 nM, 5-HT2A Ki=0.21 nM). Schizophrenia Phase 2 Discontinued |
|---|---|
| References | References 1. Geffen Y, et al. Eur Neuropsychopharmacol. 2009 Jan;19(1):1-13. 2. Nudelman A, et al. J Med Chem. 2008 May 8;51(9):2858-62. 3. Appel L, et al. Eur Neuropsychopharmacol. 2009 Dec;19(12):841-50. 4. Geffen Y, et al. J Clin Psychiatry. 2012 Sep;73(9):e1168-74. View Related Products by Target Dopamine Receptor Schizophrenia |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 635.6±55.0 °C at 760 mmHg |
| Molecular Formula | C25H34Cl2N4O2S |
| Molecular Weight | 489.073 |
| Flash Point | 338.2±31.5 °C |
| Exact Mass | 488.201263 |
| LogP | 4.52 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.602 |
| Butanoic acid, 4-amino-, 2-[4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-1-piperazinyl]ethyl ester |
| PERPHENAZINE 4-AMINOBUTYRATE |
| 2-{4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-piperazinyl}ethyl 4-aminobutanoate |