4,5-Dimethoxy-1,3,8-trihydroxyxanthone

Modify Date: 2024-04-12 00:30:38

4,5-Dimethoxy-1,3,8-trihydroxyxanthone Structure
4,5-Dimethoxy-1,3,8-trihydroxyxanthone structure
Common Name 4,5-Dimethoxy-1,3,8-trihydroxyxanthone
CAS Number 5042-09-1 Molecular Weight 304.25200
Density N/A Boiling Point N/A
Molecular Formula C15H12O7 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 4,5-Dimethoxy-1,3,8-trihydroxyxanthone


Corymbiferin is one of active constituents, responsible for anti-diabetic properties. Corymbiferin improves antioxidant capacity and carbohydrate metabolism in diabetic rats, along with the improvement of histopathology of livers and pancreatic β cells[1].

 Names

Name corymbiferin
Synonym More Synonyms

 4,5-Dimethoxy-1,3,8-trihydroxyxanthone Biological Activity

Description Corymbiferin is one of active constituents, responsible for anti-diabetic properties. Corymbiferin improves antioxidant capacity and carbohydrate metabolism in diabetic rats, along with the improvement of histopathology of livers and pancreatic β cells[1].
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In Vivo The treatment with Corymbiferin (40 mg/kg; p.o.; male Wistar rats,) reduces the FBG level significantly, similar to the effect of positive metformin on the diabetic rats[1]. Corymbiferin (400 mg/kg; p.o.) also significantly reduces the blood glucose and shows a similar effect to metformin on oral glucose tolerance test (OGTT)[1].
References

[1]. Liu Z, et al. Hypoglycemic Activity and Antioxidative Stress of Extracts and Corymbiferin from Swertia bimaculata In Vitro and In Vivo. Evid Based Complement Alternat Med. 2013;2013:125416.

 Chemical & Physical Properties

Molecular Formula C15H12O7
Molecular Weight 304.25200
Exact Mass 304.05800
PSA 109.36000
LogP 2.08020

 Synonyms

3,4-Dimethoxy-1,5,8-trihydroxy-xanthon
1,3,8-trihydroxy-4,5-dimethoxy-xanthen-9-one
1,3,8-Trihydroxy-4,5-dimethoxy-xanthen-9-on
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