5042-09-1

5042-09-1 structure

Name: 4,5-Dimethoxy-1,3,8-trihydroxyxanthone
Chemical Name: corymbiferin
CAS Number: 5042-09-1
Molecular Formula: C₁₅H₁₂O₇
Molecular Weight: 304.25200
Catalog: Research Areas Metabolic Disease
Create Date: 2017-08-15 02:27:30
Modify Date: 2024-04-12 00:30:38
Corymbiferin is one of active constituents, responsible for anti-diabetic properties. Corymbiferin improves antioxidant capacity and carbohydrate metabolism in diabetic rats, along with the improvement of histopathology of livers and pancreatic β cells[1].

Name	corymbiferin
Synonyms	3,4-Dimethoxy-1,5,8-trihydroxy-xanthon 1,3,8-trihydroxy-4,5-dimethoxy-xanthen-9-one 1,3,8-Trihydroxy-4,5-dimethoxy-xanthen-9-on

Description	Corymbiferin is one of active constituents, responsible for anti-diabetic properties. Corymbiferin improves antioxidant capacity and carbohydrate metabolism in diabetic rats, along with the improvement of histopathology of livers and pancreatic β cells[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
In Vivo	The treatment with Corymbiferin (40 mg/kg; p.o.; male Wistar rats,) reduces the FBG level significantly, similar to the effect of positive metformin on the diabetic rats[1]. Corymbiferin (400 mg/kg; p.o.) also significantly reduces the blood glucose and shows a similar effect to metformin on oral glucose tolerance test (OGTT)[1].
References	[1]. Liu Z, et al. Hypoglycemic Activity and Antioxidative Stress of Extracts and Corymbiferin from Swertia bimaculata In Vitro and In Vivo. Evid Based Complement Alternat Med. 2013;2013:125416.