| Description |
Tumulosic acid, a triterpenoid, inhibits KLK5 protease activity (IC50= 14.84 μM). Tumulosic acid suppresses the proteolytic processing of LL-37 in keratinocytes at ≤10 μM[1].
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| Related Catalog |
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| In Vitro |
Tumulosic acid displays dose-dependent anti-KLK5 activity (IC50=19.3 μM)[1]. Tumulosic acid decreases in LL-37 production in human keratinocytes[1]. Tumulosic acid shows IC50 values of 14.84 and 10.48 μM against KLK5 and trypsin proteases, while it exhibited a weak inhibitory effect on KLK7 and chymotrypsin C proteases (19.5% and 4.0%, respectively, at 100 μM)[1]. Western Blot Analysis[1] Cell Line: Normal human epidermal keratinocytes (NHEKs) Concentration: 1 μM and 10 μM Incubation Time: 23 h in the presence of 10 μM cycloheximide Result: Decreased LL-37 production in epidermal keratinocytes.
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| References |
[1]. Matsubara Y, et al. Inhibition of Human Kallikrein 5 Protease by Triterpenoids from Natural Sources. Molecules. 2017;22(11):1829. Published 2017 Oct 27.
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