Pronethalol hydrochloride

Modify Date: 2026-07-01 19:47:18

Pronethalol hydrochloride structure	Common Name	Pronethalol hydrochloride
	CAS Number	51-02-5	Molecular Weight	265.77800
	Density	1.074g/cm3	Boiling Point	322.4ºC at 760mmHg
	Molecular Formula	C₁₅H₂₀ClNO	Melting Point	N/A
	MSDS	N/A	Flash Point	84.3ºC

Use of Pronethalol hydrochloride

Pronethalol ((±)-Pronethalo) is a non-selective β-adrenergic antagonist. Pronethalol is a potent inhibitor of Sox2 expression. Pronethalol protects against and to reverse Digitalis-induced ventricular arrhythmias, and limits the cerebral arteriovenous malformation (AVMs)[1][2].

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	1-naphthalen-2-yl-2-(propan-2-ylamino)ethanol,hydrochloride
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Pronethalol ((±)-Pronethalo) is a non-selective β-adrenergic antagonist. Pronethalol is a potent inhibitor of Sox2 expression. Pronethalol protects against and to reverse Digitalis-induced ventricular arrhythmias, and limits the cerebral arteriovenous malformation (AVMs)[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease
In Vitro	Pronethalol (2, 10, 20 μM) represses EGFP expression in a dose- and time-dependent manner in ReNcell VM cells. Pronethalol (10 μM; 2 days) reduces Sox2 expression to less than 10% after 2 days of treatment[2].
In Vivo	Pronethalol (0.15 mg/g; daily; for 14 days) stabilizes endothelial differentiation, lumen formation and improves cerebral arteriovenous malformation (AVMs) in Mgp–/– mice[2].
References	[1]. Aroesty JM, et al. The effects of a beta-adrenergic blocking agent, pronethalol, on digitalis-induced ventricular arrhythmias. Am Heart J. 1966 Apr;71(4):503-508. [2]. Jiayi Yao, et al. Elevated endothelial Sox2 causes lumen disruption and cerebral arteriovenous malformations. J Clin Invest. 2019 Jun 24;129(8):3121-3133.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.074g/cm3
Boiling Point	322.4ºC at 760mmHg
Molecular Formula	C₁₅H₂₀ClNO
Molecular Weight	265.77800
Flash Point	84.3ºC
Exact Mass	265.12300
PSA	32.26000
LogP	4.06410
Index of Refraction	1.596
InChIKey	QONLGXRPRAIDGI-UHFFFAOYSA-N
SMILES	CC(C)NCC(O)c1ccc2ccccc2c1.Cl

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QJ9275000

CHEMICAL NAME :: Naphthalenemethanol, alpha-((isopropylamino)methyl)-, hydrochloride

CAS REGISTRY NUMBER :: 51-02-5

LAST UPDATED :: 199512

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C15-H19-N-O.Cl-H

MOLECULAR WEIGHT :: 265.81

WISWESSER LINE NOTATION :: L66J CYQ1MY1&1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 425 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,48,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 102 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :: IJPPAZ Indian Journal of Physiology and Pharmacology. (All India Institute of Medical Sciences, Dept. of Physiology, Ansari Nagar, New Delhi 110 029, India) V.1- 1957- Volume(issue)/page/year: 17,235,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 35 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,48,1968 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 gm/kg/25W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Endocrine - tumors

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 207,594,1965 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 13,227,1977 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 13,227,1977 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

HS Code	2922199090

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2922199090
Summary	2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN

Name: ERK5 transcriptional activity HTS
Source: 24565
Target: N/A
External Id: ERK5 transcriptional activity-HTS

Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN

Name: uHTS identification of small molecule activators of the adaptive arm of the Unfolded ...
Source: Burnham Center for Chemical Genomics
Target: N/A
External Id: BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

Name: Fluorescence polarization to screen for inhibitor that competite the binding of FadD2...
Source: Broad Institute
Target: FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE)
External Id: 2147-01_Inhibitor_SinglePoint_HTS_Activity

Name: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect...
Source: Broad Institute
Target: N/A
External Id: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

Name: Tocris HTS for Inhibitors of Aerobactin Synthetase lucA
Source: 23265
External Id: IucA Pilot Assay Tocris Library

Name: Dicer-mediated maturation of pre-microRNA
Source: Center for Chemical Genomics, University of Michigan
Target: N/A
External Id: TargetID_659_CEMA

Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

Total 130, Current Page 1 of 13

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

PRONETHALOL HYDROCHLORIDE

Pronetalol hydrochloride

Nethalide hydrochloride

DL-Pronethalol hydrochloride

Pronethalol.HCl

Naphthylisoproterenol hydrochloride

Alderlin hydrochloride

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the InChIKey of 1-naphthalen-2-yl-2-(propan-2-ylamino)ethanol,hydrochloride?

A: InChIKey of 1-naphthalen-2-yl-2-(propan-2-ylamino)ethanol,hydrochloride is QONLGXRPRAIDGI-UHFFFAOYSA-N.

Q: What is the SMILES notation of 1-naphthalen-2-yl-2-(propan-2-ylamino)ethanol,hydrochloride?

A: SMILES notation of 1-naphthalen-2-yl-2-(propan-2-ylamino)ethanol,hydrochloride is CC(C)NCC(O)c1ccc2ccccc2c1.Cl.

Q: What is the boiling point of 1-naphthalen-2-yl-2-(propan-2-ylamino)ethanol,hydrochloride?

A: Boiling point of 1-naphthalen-2-yl-2-(propan-2-ylamino)ethanol,hydrochloride is 322.4ºC at 760mmHg.

Q: What are the uses of 1-naphthalen-2-yl-2-(propan-2-ylamino)ethanol,hydrochloride?

A: Main uses of 1-naphthalen-2-yl-2-(propan-2-ylamino)ethanol,hydrochloride: Pronethalol ((±)-Pronethalo) is a non-selective β-adrenergic antagonist. Pronethalol is a potent inhibitor of Sox2 expression. Pronethalol protects against and to reverse Digitalis-induced ventricular arrhythmias, and limits the cerebral arteriovenous malformation (AVMs)[1][2].

Q: What English synonyms does 1-naphthalen-2-yl-2-(propan-2-ylamino)ethanol,hydrochloride have?

A: English synonyms of 1-naphthalen-2-yl-2-(propan-2-ylamino)ethanol,hydrochloride: PRONETHALOL HYDROCHLORIDE, Pronetalol hydrochloride, Nethalide hydrochloride, DL-Pronethalol hydrochloride, Pronethalol.HCl, Naphthylisoproterenol hydrochloride, Alderlin hydrochloride.

Q: What is the molecular formula of 1-naphthalen-2-yl-2-(propan-2-ylamino)ethanol,hydrochloride?

A: Molecular formula of 1-naphthalen-2-yl-2-(propan-2-ylamino)ethanol,hydrochloride is C15H20ClNO.

Q: What is the polar surface area (PSA) of 1-naphthalen-2-yl-2-(propan-2-ylamino)ethanol,hydrochloride?

A: Polar surface area (PSA) of 1-naphthalen-2-yl-2-(propan-2-ylamino)ethanol,hydrochloride is 32.26000.

Q: What is the LogP of 1-naphthalen-2-yl-2-(propan-2-ylamino)ethanol,hydrochloride?

A: LogP of 1-naphthalen-2-yl-2-(propan-2-ylamino)ethanol,hydrochloride is 4.06410.

Q: What is the CAS number of 1-naphthalen-2-yl-2-(propan-2-ylamino)ethanol,hydrochloride?

A: CAS number of 1-naphthalen-2-yl-2-(propan-2-ylamino)ethanol,hydrochloride is 51-02-5.

Q: What is the English name of 1-naphthalen-2-yl-2-(propan-2-ylamino)ethanol,hydrochloride?

A: The English name of 1-naphthalen-2-yl-2-(propan-2-ylamino)ethanol,hydrochloride is 1-naphthalen-2-yl-2-(propan-2-ylamino)ethanol,hydrochloride.

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