(±)-Pronethalo hydrochloride

• 常用名: (±)-Pronethalo hydrochloride
• 英文名: Pronethalol hydrochloride
• CAS号: 51-02-5
• 分子量: 265.77800
• 密度: 1.074g/cm3
• 沸点: 322.4ºC at 760mmHg
• 分子式: C₁₅H₂₀ClNO
• 熔点: N/A
• 闪点: 84.3ºC

(±)-Pronethalo hydrochloride用途

Pronethalol ((±)-Pronethalo) 是一种非选择性的 β-肾上腺素 (β-adrenergic) 拮抗剂。 Pronethalol 是有效的 Sox2 表达抑制剂。Pronethalol 可预防和逆转洋地黄引起的室性心律失常,也可以限制脑动静脉畸形 (AVMs)。

(±)-Pronethalo hydrochloride名称

• 中文名: 盐酸丙萘洛尔
• 英文名: 1-naphthalen-2-yl-2-(propan-2-ylamino)ethanol,hydrochloride
• 中文别名: 2-异丙基氨基-1-(2-萘)乙醇盐酸盐

(±)-Pronethalo hydrochloride生物活性

• 描述: Pronethalol ((±)-Pronethalo) 是一种非选择性的 β-肾上腺素 (β-adrenergic) 拮抗剂。 Pronethalol 是有效的 Sox2 表达抑制剂。Pronethalol 可预防和逆转洋地黄引起的室性心律失常,也可以限制脑动静脉畸形 (AVMs)。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体
  研究领域 >> 神经疾病
• 体外研究: 普罗沙洛尔(2,10,20μM)以剂量和时间依赖的方式抑制ReNcell-VM细胞中EGFP的表达。普诺沙洛尔(10μM；2天)在治疗2天后将Sox2表达降低到10%以下[2]。
• 体内研究: 普诺沙洛尔(0.15 mg/g；每日；持续14天)可稳定Mgp-/–小鼠的内皮分化、管腔形成和改善脑动静脉畸形(AVMs)[2]。
• 参考文献:

  [1]. Aroesty JM, et al. The effects of a beta-adrenergic blocking agent, pronethalol, on digitalis-induced ventricular arrhythmias. Am Heart J. 1966 Apr;71(4):503-508.

  [2]. Jiayi Yao, et al. Elevated endothelial Sox2 causes lumen disruption and cerebral arteriovenous malformations. J Clin Invest. 2019 Jun 24;129(8):3121-3133.

(±)-Pronethalo hydrochloride物理化学性质

• 密度: 1.074g/cm3
• 沸点: 322.4ºC at 760mmHg
• 分子式: C₁₅H₂₀ClNO
• 分子量: 265.77800
• 闪点: 84.3ºC
• 精确质量: 265.12300
• PSA: 32.26000
• LogP: 4.06410
• InChIKey: QONLGXRPRAIDGI-UHFFFAOYSA-N
• SMILES: CC(C)NCC(O)c1ccc2ccccc2c1.Cl
• 折射率: 1.596
• 储存条件: 2-8°C，密封，干燥

(±)-Pronethalo hydrochloride毒性和生态

(±)-Pronethalo hydrochloride安全信息

• 海关编码: 2922199090

(±)-Pronethalo hydrochloride海关

• 海关编码: 2922199090
• 中文概述: 2922199090. 其他氨基醇及其醚，酯和它们的盐（但含一种以上含氧基的除外）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
• 申报要素: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
• Summary: 2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

(±)-Pronethalo hydrochloride靶点实验

查看更多实验

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

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实验名称：ERK5 transcriptional activity HTS 来源：24565 靶标：N/A External Id：ERK5 transcriptional activity-HTS

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：Tocris HTS for Inhibitors of Aerobactin Synthetase lucA 来源：23265 External Id：IucA Pilot Assay Tocris Library

实验名称：Dicer-mediated maturation of pre-microRNA 来源：Center for Chemical Genomics, University of Michigan 靶标：N/A External Id：TargetID_659_CEMA

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

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(±)-Pronethalo hydrochloride英文别名

• PRONETHALOL HYDROCHLORIDE
• Pronetalol hydrochloride
• Nethalide hydrochloride
• DL-Pronethalol hydrochloride
• Pronethalol.HCl
• Naphthylisoproterenol hydrochloride
• Alderlin hydrochloride