yamogenin

Modify Date: 2025-09-12 20:34:54

yamogenin Structure
yamogenin structure
 Common Name yamogenin
CAS Number 512-06-1 Molecular Weight 414.621
Density 1.1±0.1 g/cm3 Boiling Point 527.1±50.0 °C at 760 mmHg
Molecular Formula C27H42O3 Melting Point N/A
MSDS N/A Flash Point 272.6±30.1 °C

 Use of yamogenin


Yamogenin (Neodiosgenin) is a diastereomer of diosgenin. Yamogenin (Neodiosgenin) antagonizes the activation of the liver X receptor (LXR) in luciferase ligand assay. Yamogenin (Neodiosgenin) inhibits triacylglyceride (TG) accumulation through the suppression of gene expression of fatty acid synthesis in HepG2 hepatocytes[1].

 Names

Name Yamogenin
Synonym More Synonyms

 yamogenin Biological Activity

Description Yamogenin (Neodiosgenin) is a diastereomer of diosgenin. Yamogenin (Neodiosgenin) antagonizes the activation of the liver X receptor (LXR) in luciferase ligand assay. Yamogenin (Neodiosgenin) inhibits triacylglyceride (TG) accumulation through the suppression of gene expression of fatty acid synthesis in HepG2 hepatocytes[1].
Related Catalog
Target

IC50: TG accumulation; liver X receptor (LXR)[1]

References

[1]. Moriwaki S, et al. Yamogenin in fenugreek inhibits lipid accumulation through the suppression of gene expression in fatty acid synthesis in hepatocytes.Biosci Biotechnol Biochem. 2014;78(7):1231-6.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 527.1±50.0 °C at 760 mmHg
Molecular Formula C27H42O3
Molecular Weight 414.621
Flash Point 272.6±30.1 °C
Exact Mass 414.313385
PSA 38.69000
LogP 5.84
Vapour Pressure 0.0±3.1 mmHg at 25°C
Index of Refraction 1.564
InChIKey WQLVFSAGQJTQCK-CAKNJAFZSA-N
SMILES CC1CCC2(OC1)OC1CC3C4CC=C5CC(O)CCC5(C)C4CCC3(C)C1C2C
Storage condition -20℃

 yamogeninBioassay

View more

Name: Cytotoxicity against human MDA-MB-231 cells
Source: ChEMBL
Target: MDA-MB-231
External Id: CHEMBL2379890
Name: Cytotoxicity against human A549 cells
Source: ChEMBL
Target: A549
External Id: CHEMBL2379889
Name: Cytotoxicity against human Hep3B cells
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL2379893
Name: Cytotoxicity against human HepG2 cells
Source: ChEMBL
Target: HepG2
External Id: CHEMBL2379892
Name: Cytotoxicity against human MCF7 cells
Source: ChEMBL
Target: MCF7
External Id: CHEMBL2379891
Total 5, Current Page 1 of 1
1

 Synonyms

(3β,25S)-Spirost-5-en-3-ol
yamogenin
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