1H-Benzimidazol-2-amine,N-butyl-

Modify Date: 2024-01-17 14:54:12

1H-Benzimidazol-2-amine,N-butyl- Structure
1H-Benzimidazol-2-amine,N-butyl- structure
Common Name 1H-Benzimidazol-2-amine,N-butyl-
CAS Number 51314-51-3 Molecular Weight 189.26
Density 1.153g/cm3 Boiling Point 344.8ºC at 760 mmHg
Molecular Formula C11H15N3 Melting Point N/A
MSDS N/A Flash Point 162.3ºC

 Use of 1H-Benzimidazol-2-amine,N-butyl-


M084 is a benzimidazole derivative. M084 inhibits the mitochondrial respiration, activate mitochondrial unfolded protein response and AMPK, recruites SIR-2.1 and SKN-1, and finally through the transcription factor DAF-16, delays the aging process of C. elegans[1].

 Names

Name butyl(1,3-dihydrobenzimidazol-2-ylidene)azanium
Synonym More Synonyms

 1H-Benzimidazol-2-amine,N-butyl- Biological Activity

Description M084 is a benzimidazole derivative. M084 inhibits the mitochondrial respiration, activate mitochondrial unfolded protein response and AMPK, recruites SIR-2.1 and SKN-1, and finally through the transcription factor DAF-16, delays the aging process of C. elegans[1].
Related Catalog
References

[1]. Ai-Jun Ding, et al. Benzimidazole derivative M084 extends the lifespan of Caenorhabditis elegans in a DAF-16/FOXO-dependent way. Mol Cell Biochem. 2017 Feb;426(1-2):101-109.  

 Chemical & Physical Properties

Density 1.153g/cm3
Boiling Point 344.8ºC at 760 mmHg
Molecular Formula C11H15N3
Molecular Weight 189.26
Flash Point 162.3ºC
Exact Mass 189.12700
PSA 40.71000
LogP 2.84790
Index of Refraction 1.653

 Safety Information

HS Code 2933990090

 Synthetic Route

~57%

1H-Benzimidazol-2-amine,N-butyl- Structure

1H-Benzimidazol...

CAS#:51314-51-3

Literature: Linciano, Pasquale; Pizzetti, Marianna; Porcheddu, Andrea; Taddei, Maurizio Synlett, 2013 , vol. 24, # 17 p. 2249 - 2254

~90%

1H-Benzimidazol-2-amine,N-butyl- Structure

1H-Benzimidazol...

CAS#:51314-51-3

Literature: Zhu, Jinmei; Wu, Chun-Feng; Li, Xiaobing; Wu, Gui-Sheng; Xie, Shan; Hu, Qian-Nan; Deng, Zixin; Zhu, Michael X.; Luo, Huai-Rong; Hong, Xuechuan Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 14 p. 4218 - 4224

~95%

1H-Benzimidazol-2-amine,N-butyl- Structure

1H-Benzimidazol...

CAS#:51314-51-3

Literature: Li, Feng; Kang, Qikai; Shan, Haixia; Chen, Lin; Xie, Jianjiang European Journal of Organic Chemistry, 2012 , # 26 p. 5085 - 5092

~71%

1H-Benzimidazol-2-amine,N-butyl- Structure

1H-Benzimidazol...

CAS#:51314-51-3

Literature: Zhu, Tong-Hao; Wang, Shun-Yi; Wang, Gao-Nan; Ji, Shun-Jun Chemistry - A European Journal, 2013 , vol. 19, # 19 p. 5850 - 5853

~%

1H-Benzimidazol-2-amine,N-butyl- Structure

1H-Benzimidazol...

CAS#:51314-51-3

Literature: Barrett, Ian C.; Kerr, Michael A. Tetrahedron Letters, 1999 , vol. 40, # 13 p. 2439 - 2442

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1H-Benzimidazol-2-amine,N-butyl- Structure

1H-Benzimidazol...

CAS#:51314-51-3

Literature: Tittelbach, Franz; Martin, Dieter Journal fuer Praktische Chemie (Leipzig), 1988 , vol. 330, # 3 p. 338 - 348

~%

1H-Benzimidazol-2-amine,N-butyl- Structure

1H-Benzimidazol...

CAS#:51314-51-3

Literature: Tittelbach, Franz; Martin, Dieter Journal fuer Praktische Chemie (Leipzig), 1988 , vol. 330, # 3 p. 338 - 348

~%

1H-Benzimidazol-2-amine,N-butyl- Structure

1H-Benzimidazol...

CAS#:51314-51-3

Literature: Tittelbach, Franz; Martin, Dieter Journal fuer Praktische Chemie (Leipzig), 1988 , vol. 330, # 3 p. 338 - 348

~%

1H-Benzimidazol-2-amine,N-butyl- Structure

1H-Benzimidazol...

CAS#:51314-51-3

Literature: Tittelbach, Franz; Martin, Dieter Journal fuer Praktische Chemie (Leipzig), 1988 , vol. 330, # 3 p. 338 - 348

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

2-N-butylamino-1H-benzimidazole
2-n-Butylaminobenzimidazol
N-Butyl-1H-Benzimidazol-2-Amine