Tizanidine
Modify Date: 2024-01-03 10:14:57
Tizanidine structure
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Common Name | Tizanidine | ||
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| CAS Number | 51322-75-9 | Molecular Weight | 253.71100 | |
| Density | 1.82 g/cm3 | Boiling Point | 391.2ºC at 760 mmHg | |
| Molecular Formula | C9H8ClN5S | Melting Point | 221 - 223ºC | |
| MSDS | N/A | Flash Point | 190.4ºC | |
| Purity | Quantity | Budget | Inquiry |
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Use of TizanidineTizanidine is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons.Target: α2-adrenergic receptorTizanidine is a drug that is used as a muscle relaxant. It is a centrally acting α2 adrenergic agonist. It is used to treat the spasms, cramping, and tightness of muscles caused by medical problems such as multiple sclerosis, ALS, spastic diplegia, back pain, or certain other injuries to the spine or central nervous system. It is also prescribed off-label for migraine headaches, as a sleep aid, and as an anticonvulsant. It is also prescribed for some symptoms of fibromyalgia.Tizanidine has been found to be as effective as other antispasmodic drugs and has superior tolerability to that of baclofen and diazepam. Tizanidine can be very strong even at the 2 mg dose and may cause hypotension, so caution is advised when it is used in patients who have a history of orthostatic hypotension, or when switching from gel cap to tablet form and vice versa. Tizanidine can occasionally cause liver damage, generally the hepatocellular type. Clinical trials show that up to 5% of patients treated with tizanidine had elevated liver function test values, though symptoms disappeared upon withdrawal of the drug. Care should be used when first beginning treatment with tizanidine with regular liver tests for the first 6 months of treatment. |
| Name | tizanidine |
|---|---|
| Synonym | More Synonyms |
| Description | Tizanidine is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons.Target: α2-adrenergic receptorTizanidine is a drug that is used as a muscle relaxant. It is a centrally acting α2 adrenergic agonist. It is used to treat the spasms, cramping, and tightness of muscles caused by medical problems such as multiple sclerosis, ALS, spastic diplegia, back pain, or certain other injuries to the spine or central nervous system. It is also prescribed off-label for migraine headaches, as a sleep aid, and as an anticonvulsant. It is also prescribed for some symptoms of fibromyalgia.Tizanidine has been found to be as effective as other antispasmodic drugs and has superior tolerability to that of baclofen and diazepam. Tizanidine can be very strong even at the 2 mg dose and may cause hypotension, so caution is advised when it is used in patients who have a history of orthostatic hypotension, or when switching from gel cap to tablet form and vice versa. Tizanidine can occasionally cause liver damage, generally the hepatocellular type. Clinical trials show that up to 5% of patients treated with tizanidine had elevated liver function test values, though symptoms disappeared upon withdrawal of the drug. Care should be used when first beginning treatment with tizanidine with regular liver tests for the first 6 months of treatment. |
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| Related Catalog | |
| References |
| Density | 1.82 g/cm3 |
|---|---|
| Boiling Point | 391.2ºC at 760 mmHg |
| Melting Point | 221 - 223ºC |
| Molecular Formula | C9H8ClN5S |
| Molecular Weight | 253.71100 |
| Flash Point | 190.4ºC |
| Exact Mass | 253.01900 |
| PSA | 90.44000 |
| LogP | 1.55320 |
| Storage condition | -20℃ |
| Water Solubility | H2O: ~29 mg/mL |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Hazard Codes | Xn: Harmful; |
|---|---|
| Risk Phrases | R22 |
| Safety Phrases | 26-36 |
| WGK Germany | 3 |
| RTECS | DK9910000 |
| HS Code | 2934999090 |
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine |
| 5-chloro-N-(imidazolidin-2-ylidene)-2,1,3-benzothiadiazol-4-amine |
| Sirdalud |
| Ternelin |
| [14C]-Tizanidine |
| Tizanidina [INN-Spanish] |
| Zanaflex(R) |
| Tizanidina |
| MFCD00798231 |
| Tizanidinum |
| Zanaflex |
| UNII-6AI06C00GW |
| 5-chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazole |
| Tizanidinum [INN-Latin] |