cis-(Z)-Flupentixol dihydrochloride

Modify Date: 2025-08-20 18:14:42

cis-(Z)-Flupentixol dihydrochloride structure	Common Name	cis-(Z)-Flupentixol dihydrochloride
	CAS Number	51529-01-2	Molecular Weight	507.440
	Density	N/A	Boiling Point	554.7ºC at 760 mmHg
	Molecular Formula	C₂₃H₂₇Cl₂F₃N₂OS	Melting Point	194-202ºC
	MSDS	Chinese USA	Flash Point	289.3ºC
	Symbol	GHS07	Signal Word	Warning

Use of cis-(Z)-Flupentixol dihydrochloride

cis-(Z)-Flupentixol dihydrochloride is a potent and selective DA D1/D2 receptor antagonist, with Ki values of 0.38 nM and 7 nM for D2 receptor and 5-HT2A, respectively[1][2].

Name	Flupenthixol dihydrochloride
Synonym	More Synonyms

Description	cis-(Z)-Flupentixol dihydrochloride is a potent and selective DA D1/D2 receptor antagonist, with Ki values of 0.38 nM and 7 nM for D2 receptor and 5-HT2A, respectively[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	D2 Receptor:0.38 nM (Ki) 5-HT2A Receptor:7 nM (Ki)
In Vivo	cis-(Z)-Flupentixol (0.25, or 0.5 mg/kg, i.p.) pretreatment dose-dependently reduces cocaine-induced activity[1]. Animal Model: Rats[1]. Dosage: 0.125, 0.25, or 0.5 mg/kg. Administration: IP. Result: Reduced cocaine-induced activity.
References	[1]. Jennifer M Wenzel, et al. The dopamine antagonist cis-flupenthixol blocks the expression of the conditioned positive but not the negative effects of cocaine in rats. Pharmacol Biochem Behav. 2013 Dec;114-115:90-6. [2]. Philip Seeman, et al. Atypical antipsychotics: mechanism of action. Can J Psychiatry. 2002 Feb;47(1):27-38.

Boiling Point	554.7ºC at 760 mmHg
Melting Point	194-202ºC
Molecular Formula	C₂₃H₂₇Cl₂F₃N₂OS
Molecular Weight	507.440
Flash Point	289.3ºC
Exact Mass	506.117310
PSA	52.01000
LogP	6.08150
Appearance of Characters	white to off-white
InChIKey	ZQAWQVWCKYGMNE-CVIBNLPVSA-N
SMILES	Cl.OCCN1CCN(CCC=C2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1
Storage condition	-20°C Freezer
Water Solubility	H2O: soluble

cis-(Z)-Flupentixol dihydrochloride MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302 + H312 + H332
Precautionary Statements	P261-P280-P301 + P312 + P330
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R20/21/22
Safety Phrases	S36/37/39
RIDADR	UN 2811
RTECS	TL9900000
HS Code	2942000000

HS Code	2942000000

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Target: ORF 73 [Human herpesvirus 8 type M]
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Target: interleukin-1 receptor-like 1 isoform [homo sapiens]
External Id: ST2_IL33_Inhibitors_Primary_Screening_77700

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Source: NCGC
Target: N/A
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1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)thioxanthen-9-ylidene)propyl)-, dihydrochloride (8CI)

(Z)-4-(3-(2-(Trifluoromethyl)-9H-thioxanthen-9-ylidene)propyl)-1-piperazineethanol dihydrochloride

1-Piperazineethanol, 4-[3-[2- (trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl]-, dihydrochloride

cis-Flupentixol Hydrochloride

FUPENTIXOL DIHYDROCHLORIDE

FLUPENTIXOL DIHYDROCHLORIDE

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Fupentixol HCl

4-[3-[2-(Trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl]-1-piperazineethanol dihydrochloride

(Z)-4-[3-[2-(Trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl]-1-piperazineethanol dihydrochloride

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Metamin

1-Piperazineethanol, 4-[(3E)-3-[2-(trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl]-, hydrochloride (1:2)

Thioxanthene, 9-(3-(4-(2-hydroxyethyl)piperazinyl)propylidene)-2-trifluoromethyl-, dihydrochloride

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1-Piperazineethanol, 4-[(3Z)-3-[2-(trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl]-, hydrochloride (1:2)

2-(4-{(3Z)-3-[2-(Trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl}-1-piperazinyl)ethanol dihydrochloride

1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)-9H-thioxanthen-9-ylidene)propyl)-, dihydrochloride (9CI)

CIS-(Z)-FLUPENTHIXOL DIHYDROCHLORIDE ANT IPSYCHOTIC,NEUROL

1-Piperazineethanol, 4-[3-[2- (trifluoromethyl)thioxanthen-9-ylidene]propyl]-, dihydrochloride

2-(4-{(3Z)-3-[2-(Trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl}piperazin-1-yl)ethanol dihydrochloride

flupentixolhydrochloride

fx703

cis-(Z)-Flupentixol Dihydrochloride

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China
Product Name: cis-(Z)-Flupentixol dihydrochloride
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