4-Methoxylonchocarpin

Modify Date: 2024-08-02 11:21:51

4-Methoxylonchocarpin structure	Common Name	4-Methoxylonchocarpin
	CAS Number	51589-67-4	Molecular Weight	336.38
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₂₀O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 4-Methoxylonchocarpin

4-Methoxylonchocarpin is an orally active anti-inflammatory agent. 4-methoxylonchocarpin inhibits the binding of LPS to Toll-like Receptor (TLR) TLR4 to inhibit NF-κB activation and TNF Receptor and IL-6 expression. 4-Methoxylonchocarpin also inhibits the phosphorylation of TGF-beta activated kinase 1 and TNBS-induced expression of IL-1β, IL-17A, and TNF. 4-methoxylonchocarpin can improve 2,4, 6-trinitrobenzene sulfonic acid (TNBS)-induced colitis mouse model[1].

Name	(E)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(4-methoxyphenyl)prop-2-en-1-one
Synonym	More Synonyms

Description	4-Methoxylonchocarpin is an orally active anti-inflammatory agent. 4-methoxylonchocarpin inhibits the binding of LPS to Toll-like Receptor (TLR) TLR4 to inhibit NF-κB activation and TNF Receptor and IL-6 expression. 4-Methoxylonchocarpin also inhibits the phosphorylation of TGF-beta activated kinase 1 and TNBS-induced expression of IL-1β, IL-17A, and TNF. 4-methoxylonchocarpin can improve 2,4, 6-trinitrobenzene sulfonic acid (TNBS)-induced colitis mouse model[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR) Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Research Areas >> Inflammation/Immunology
References	[1]. Jang HM, et al. 4-Methoxylonchocarpin attenuates inflammation by inhibiting lipopolysaccharide binding to Toll-like receptor of macrophages and M1 macrophage polarization. Int Immunopharmacol. 2017 Apr;45:90-97.

Molecular Formula	C₂₁H₂₀O₄
Molecular Weight	336.38
Exact Mass	336.13600
PSA	55.76000
LogP	4.48110

4-methoxylonchocarpin

(E)-1-(5-Hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(4-methoxy-phenyl)-propenone

1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(4-methoxyphenyl)-propenone

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 4-Methoxylonchocarpin
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

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4-Methoxylonchocarpin

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