4-Methoxylonchocarpin

• 常用名: 4-Methoxylonchocarpin
• 英文名: 4-Methoxylonchocarpin
• CAS号: 51589-67-4
• 分子量: 336.38
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₂₀O₄
• 熔点: N/A
• 闪点: N/A

4-Methoxylonchocarpin用途

4-甲氧基onchocarpin是一种口服活性抗炎剂。4-甲氧基巧克力卡平抑制LPS与Toll样受体(TLR)TLR4的结合,以抑制NF-κB的激活以及TNF受体和IL-6的表达。4-甲氧基onchocarpin还抑制TGF-β活化激酶1的磷酸化和TNBS诱导的IL-1β、IL-17A和TNF的表达。4-甲氧基巧克力胶对2,4,6-三硝基苯磺酸(TNBS)诱导的结肠炎小鼠模型有一定的改善作用[1]。

4-Methoxylonchocarpin名称

• 英文名: (E)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(4-methoxyphenyl)prop-2-en-1-one

4-Methoxylonchocarpin生物活性

• 描述: 4-甲氧基onchocarpin是一种口服活性抗炎剂。4-甲氧基巧克力卡平抑制LPS与Toll样受体(TLR)TLR4的结合,以抑制NF-κB的激活以及TNF受体和IL-6的表达。4-甲氧基onchocarpin还抑制TGF-β活化激酶1的磷酸化和TNBS诱导的IL-1β、IL-17A和TNF的表达。4-甲氧基巧克力胶对2,4,6-三硝基苯磺酸(TNBS)诱导的结肠炎小鼠模型有一定的改善作用[1]。
• 相关类别:
  信号通路 >> 免疫及炎症 >> Toll样受体(TLR)
  信号通路 >> 免疫及炎症 >> 白细胞介素相关
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Jang HM, et al. 4-Methoxylonchocarpin attenuates inflammation by inhibiting lipopolysaccharide binding to Toll-like receptor of macrophages and M1 macrophage polarization. Int Immunopharmacol. 2017 Apr;45:90-97.

4-Methoxylonchocarpin物理化学性质

• 分子式: C₂₁H₂₀O₄
• 分子量: 336.38
• 精确质量: 336.13600
• PSA: 55.76000
• LogP: 4.48110
• InChIKey: XEVCTBKORYCFCZ-UXBLZVDNSA-N
• SMILES: COc1ccc(C=CC(=O)c2ccc3c(c2O)C=CC(C)(C)O3)cc1

4-Methoxylonchocarpin靶点实验

查看更多实验

实验名称：Antimalarial activity against schizont stage of chloroquine-sensitive Plasmodium falc... 来源：ChEMBL 靶标：Plasmodium falciparum External Id：CHEMBL2345246

实验名称：Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induc... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL2045193

实验名称：Selectivity index, ratio of IC50 for inhibition of AChE (unknown origin) to IC50 for ... 来源：ChEMBL 靶标：Cholinesterases; ACHE & BCHE External Id：CHEMBL4321438

实验名称：Antimalarial activity against schizont stage of chloroquine-sensitive Plasmodium falc... 来源：ChEMBL 靶标：Plasmodium falciparum External Id：CHEMBL2345249

实验名称：Inhibition of BChE (unknown origin) using butyrylthiocholine iodide as substrate by s... 来源：ChEMBL 靶标：Cholinesterase External Id：CHEMBL4321437

实验名称：Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate by sp... 来源：ChEMBL 靶标：Acetylcholinesterase External Id：CHEMBL4321436

实验名称：Inhibition of BChE (unknown origin) at 20 ug/mL using butyrylthiocholine iodide as su... 来源：ChEMBL 靶标：Cholinesterase External Id：CHEMBL4321435

实验名称：Antiproliferative activity against human K562 cells assessed as reduction in cell via... 来源：ChEMBL 靶标：K562 External Id：CHEMBL4702758

实验名称：In-vitro antileishmanial activity was tested against extracellular promastigotes of L... 来源：ChEMBL 靶标：Leishmania donovani External Id：CHEMBL874347

实验名称：Antiproliferative activity against human MV4-11 cells assessed as reduction in cell v... 来源：ChEMBL 靶标：MV4-11 External Id：CHEMBL4702755

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4-Methoxylonchocarpin英文别名

• 4-methoxylonchocarpin
• (E)-1-(5-Hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(4-methoxy-phenyl)-propenone
• 1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(4-methoxyphenyl)-propenone