Corydaline

Modify Date: 2025-08-20 19:20:45

Corydaline Structure
Corydaline structure
 Common Name Corydaline
CAS Number 518-69-4 Molecular Weight 369.454
Density 1.2±0.1 g/cm3 Boiling Point 482.3±45.0 °C at 760 mmHg
Molecular Formula C22H27NO4 Melting Point 135°
MSDS N/A Flash Point 135.7±25.9 °C

 Use of Corydaline


Corydaline is an acetylcholinesterase inhibitor isolated from Corydalis yanhusuo.

 Names

Name corydaline
Synonym More Synonyms

 Corydaline Biological Activity

Description Corydaline is an acetylcholinesterase inhibitor isolated from Corydalis yanhusuo.
Related Catalog
References

[1]. Xiao HT, et al. Acetylcholinesterase inhibitors from Corydalis yanhusuo. Nat Prod Res. 2011 Sep;25(15):1418-22.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 482.3±45.0 °C at 760 mmHg
Melting Point 135°
Molecular Formula C22H27NO4
Molecular Weight 369.454
Flash Point 135.7±25.9 °C
Exact Mass 369.194000
PSA 40.16000
LogP 4.19
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.600
Storage condition -20°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GN0600000
CHEMICAL NAME :
Corydaline
CAS REGISTRY NUMBER :
518-69-4
BEILSTEIN REFERENCE NO. :
0096972
LAST UPDATED :
199709
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C22-H27-N-O4
MOLECULAR WEIGHT :
369.50
WISWESSER LINE NOTATION :
T D6 B666 KN&TT&J C1 GO1 HO1 PO1 QO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
136 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 5,163,1946

 Synthetic Route

9,10-dimethoxy-13-methyl-5,8,13,13a-tetrahydro-6h-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinoline structure

9,10-dimethoxy-...

CAS#:29550-24-1

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Corydaline Structure

Corydaline

CAS#:518-69-4

Literature: Manske Journal of the American Chemical Society, 1953 , vol. 75, p. 4928
corydaline structure

corydaline

CAS#:883833-45-2

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Corydaline Structure

Corydaline

CAS#:518-69-4

Literature: CVI PHARMACEUTICALS LIMITED; LIU, Haiyan; LI, Gaoping; WANG, Junbo; LIU, Jingwen Patent: WO2010/75469 A1, 2010 ; Location in patent: Page/Page column 62 ; WO 2010/075469 A1
methyl iodide structure

methyl iodide

CAS#:74-88-4

~%

Corydaline Structure

Corydaline

CAS#:518-69-4

Literature: Dobbie; Lauder; Paliatseas Journal of the Chemical Society, 1901 , vol. 79, p. 89
[1R-(endo,anti)]-3-bromo-2-oxobornane-8-sulphonic acid structure

[1R-(endo,anti)...

CAS#:5344-58-1

6H-Dibenzo[a,g]quinolizine,5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-13-methyl-, (13R,13aS)-rel- structure

6H-Dibenzo[a,g]...

CAS#:6018-35-5

~%

Corydaline Structure

Corydaline

CAS#:518-69-4

Literature: Gadamer; Wagner Archiv der Pharmazie (Weinheim, Germany), 1902 , vol. 240, p. 36
Tartaric acid structure

Tartaric acid

CAS#:87-69-4

6H-Dibenzo[a,g]quinolizine,5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-13-methyl-, (13R,13aS)-rel- structure

6H-Dibenzo[a,g]...

CAS#:6018-35-5

~%

Corydaline Structure

Corydaline

CAS#:518-69-4

Literature: Gadamer; Wagner Archiv der Pharmazie (Weinheim, Germany), 1902 , vol. 240, p. 36

 Synonyms

13aβ-Berbine, 2,3,9,10-tetramethoxy-13α-methyl-
(13S,13aR)-2,3,9,10-tetramethoxy-13-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline
d-Corydalin
(13S,13aR)-2,3,9,10-Tetramethoxy-13-methyl-5,8,13,13a-tetrahydro-6H-isoquinolino[3,2-a]isoquinoline
(13S-trans )-5,8,13,13a-Tetrahydro-2,3,9,10-tetramethoxy-13-methyl-6H-dibenzo[a,g]quinolizine
Corydaline (+)
6H-Dibenzo[a,g]quinolizine, 5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-13-methyl-, (13S,13aR)-
Berbine,2,3,9,10-tetramethoxy-13-methyl
2,3,9,10-Tetramethoxy-13a-methyl-13ab-berbine
(13S,13aR)-2,3,9,10-Tetramethoxy-13-methyl-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline
Corydalin
Corydaline
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corydaline
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