Dehydrocorydalin

Modify Date: 2024-01-02 02:18:16

Dehydrocorydalin structure	Common Name	Dehydrocorydalin
	CAS Number	30045-16-0	Molecular Weight	366.43000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₂₄NO₄+	Melting Point	170-173℃
	MSDS	N/A	Flash Point	N/A

Use of Dehydrocorydalin

Dehydrocorydaline (13-Methylpalmatine) is an alkaloid isolated from traditional Chinese herb Corydalis yanhusuo W.T. Wang. Dehydrocorydaline regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP.

Name	Dehydrocorydaline
Synonym	More Synonyms

Description	Dehydrocorydaline (13-Methylpalmatine) is an alkaloid isolated from traditional Chinese herb Corydalis yanhusuo W.T. Wang. Dehydrocorydaline regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP.
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Signaling Pathways >> Apoptosis >> Caspase Signaling Pathways >> Cell Cycle/DNA Damage >> PARP Signaling Pathways >> Epigenetics >> PARP Natural Products >> Alkaloid Research Areas >> Cancer
Target	Bcl-2 Bax Caspase-7 Caspase-8 PARP
In Vitro	Dehydrocorydaline (0-200 μM) treatment significantly inhibits the growth of MCF-7 cells in a dose-dependent manner. The cell viability is decreased by approximate 40% after 24 h of 200 μM Dehydrocorydaline[1]. Dehydrocorydaline (0-200 μM)dose-dependently increases Bax protein expression and decreases Bcl-2 protein expression[1]. Dehydrocorydaline (0-200 μM)induces activation of caspase-7,-8 and the cleavage of PARP without affecting caspase-9[1].
In Vivo	Dehydrocorydaline manifests a low acute toxicity with an LD50 of about 277.5±19.0 mg/kg body weight in mice following oral administration and 21.1±1.4 mg/kg for intraperitoneal injection[2].
References	[1]. Xu Z, et al. Dehydrocorydaline inhibits breast cancer cells proliferation by inducing apoptosis in MCF-7 cells. Am J Chin Med. 2012;40(1):177-85. [2]. Yin ZY, et al. Antinociceptive effects of dehydrocorydaline in mouse models of inflammatory pain involve the opioid receptor and inflammatory cytokines. Sci Rep. 2016 Jun 7;6:27129.

Melting Point	170-173℃
Molecular Formula	C₂₂H₂₄NO₄+
Molecular Weight	366.43000
Exact Mass	366.17100
PSA	40.80000
LogP	3.69320
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DR9868000

CHEMICAL NAME :: Berbinium, 7,8,13,13a-tetradehydro-2,3,9,10-tetramethoxy-13-meth yl-

CAS REGISTRY NUMBER :: 30045-16-0

BEILSTEIN REFERENCE NO. :: 1556798

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C22-H24-N-O4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 78 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 84,73,1964

HS Code	2933990090

Corydaline

CAS#:518-69-4

Dehydrocorydalin

CAS#:30045-16-0

Literature: Archiv der Pharmazie (Weinheim, Germany), , vol. 253, p. 266,270 Archiv der Pharmazie (Weinheim, Germany), , vol. 256, p. 155,185

mercuric acetate

CAS#:1600-27-7

acetic acid

CAS#:64-19-7

Corydaline

CAS#:518-69-4

Dehydrocorydalin

CAS#:30045-16-0

Literature: Archiv der Pharmazie (Weinheim, Germany), , vol. 256, p. 155,185

nitric acid

CAS#:7697-37-2

Corydaline

CAS#:518-69-4

Dehydrocorydalin

CAS#:30045-16-0

Literature: Archiv der Pharmazie (Weinheim, Germany), , vol. 243, p. 181 Journal of the Chemical Society, , vol. 71, p. 663

Water

CAS#:7732-18-5

Corydaline

CAS#:518-69-4

Dehydrocorydalin

CAS#:30045-16-0

Literature: Journal of the Chemical Society, , vol. 71, p. 663

Ethanol

CAS#:64-17-5

molecular iodine

CAS#:7553-56-2

Corydaline

CAS#:518-69-4

Dehydrocorydalin

CAS#:30045-16-0

Literature: Archiv der Pharmazie (Weinheim, Germany), , vol. 234, p. 505

Precursor 7
CAS#:518-69-4 Corydaline CAS#:1600-27-7 mercuric acetate CAS#:64-19-7 acetic acid CAS#:7697-37-2 nitric acid
CAS#:7732-18-5 Water CAS#:64-17-5 Ethanol CAS#:7553-56-2 molecular iodine
DownStream 0

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

dehydrocorydalmine

dehydeocorydaline

5,6-Dihydro-2,3,9,10-tetramethoxy-13-methyldibenzo[a,g]quinolizinium

2,3,9,10-Tetramethoxy-13-methyl-5,6-dihydro-isochino[3,2-a]isochinolinylium

Dehydrocorydalin

13-Methyl-2,3,9,10-tetramethoxy-5,6-dihydrodibenzo[a,g]quinolizinium

13-methylpalmatine

2,3,9,10-tetramethoxy-13-methyl-5,6-dihydro-isoquino[3,2-a]isoquinolinylium

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Dehydrocorydalin
Price: Click To Check
Purity: 97.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

BioBioPha
China
Product Name: Dehydrocorydalin
Price: ￥Inquiry/5mg
Purity: 98.0%
Delivery: 10 Day
Contact: Xueping-Zheng
Email: 1477035482@qq.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Dehydrocorydalin
Price: ￥1600.0/5mg
Purity: 98.0%
Delivery: 1 Day
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: Dehydrocorydaline
Price: $280.0/20mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Dehydrocorydaline
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Get all suppliers and price by the below link:

Dehydrocorydalin suppliers

Price: ￥1400/5 mg

Reference only. check more Dehydrocorydalin price

Dehydrocorydalin

Use of Dehydrocorydalin

Names