STO609

Modify Date: 2026-07-22 11:24:29

STO609 Structure
STO609 structure
 Common Name STO609
CAS Number 52029-86-4 Molecular Weight 314.29
Density N/A Boiling Point 797.3ºC at 760 mmHg
Molecular Formula C19H10N2O3 Melting Point >300ºC
MSDS N/A Flash Point 436ºC

 Use of STO609


STO-609 is a selective and cell-permeable inhibitor of the Ca2+/calmodulin-dependent protein kinase kinase (CaM-KK), with Ki values of 80 and 15 ng/mL for recombinant CaM-KKα and CaM-KKβ, respectively.

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name STO-609 acetate,7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylicacidacetate
Synonym More Synonyms

 STO609 Biological Activity

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description STO-609 is a selective and cell-permeable inhibitor of the Ca2+/calmodulin-dependent protein kinase kinase (CaM-KK), with Ki values of 80 and 15 ng/mL for recombinant CaM-KKα and CaM-KKβ, respectively.
Related Catalog
Target

Ki: 80 ng/mL (CaM-KKα), 15 ng/mL (CaM-KKβ)[1]

In Vitro STO-609 inhibits the activities of recombinant CaM-KKα and CaM-KKβ isoforms, with Ki values of 80 and 15 ng/mL, respectively, and also inhibits their autophosphorylation activities. STO-609 is highly selective for CaM-KK without any significant effect on the downstream CaM kinases (CaM-KI and -IV), and the IC50 value of the compound against CaM-KII is 10 μg/mL. STO-609 inhibits constitutively active CaM-KKα as well as the wild-type enzyme. In transfected HeLa cells, STO-609 suppresses the Ca2+-induced activation of CaM-KIV in a dose-dependent manner. STO-609 significantly reduces the endogenous activity of CaM-KK in SH-SY5Y neuroblastoma cells at a concentration of 1μg/mL (80% inhibitory rate)[1].
Kinase Assay CaM-KI (2.5 μg/mL), CaM-KII (0.75 μg/mL), CaM-KIV (9 μg/mL), and mLCK (0.6 μg/mL) are incubated with 40 μM syntide-2 or 50 μM mLC peptide (for mLCK) at 30 °C for 5 min in a solution (25 μL) containing 50 mM HEPES (pH 7.5), 10 mM Mg(Ac)2, 1 mM DTT, 50 μM [γ-32P]ATP (4500 cpm/pmol) with various concentrations of STO-609 (0–10 μg/mL)in Me2SO at a final concentration of 4%) in the presence of 1 mM CaCl2, 2 μM CaM. Protein kinase activity is measured by the phosphocellulose filter method. Specific activities of CaM-KI, CaM-KII, CaM-KIV, and mLCK in the absence of STO-609 are calculated[1]. STO-609 is bound in the ATP-binding pocket of the CaMKKβ KD. The inhibition mechanism of STO-609 is ATP-competitive[2].
References

[1]. Tokumitsu H, et al. STO-609, a specific inhibitor of the Ca(2+)/calmodulin-dependent protein kinase kinase. J Biol Chem. 2002 May 3;277(18):15813-8.

[2]. Kukimoto-Niino M, et al. Crystal structure of the Ca??/calmodulin-dependent protein kinase kinase in complex with the inhibitor STO-609. J Biol Chem. 2011 Jun 24;286(25):22570-9.

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Boiling Point 797.3ºC at 760 mmHg
Melting Point >300ºC
Molecular Formula C19H10N2O3
Molecular Weight 314.29
Flash Point 436ºC
PSA 108.97000
LogP 3.38100
Appearance of Characters yellow solid
InChIKey MYKOWOGZBMOVBJ-UHFFFAOYSA-N
SMILES O=C(O)c1ccc2c3c1cccc3c(=O)n1c3ccccc3nc21
Storage condition -20℃

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Safety Phrases 22-24/25
WGK Germany 3
HS Code 2933990090

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 STO609Bioassay

View more

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Cytotoxicity activity against human HepG2 cells assessed by CellTiter-Glo luminescent...
Source: ChEMBL
Target: HepG2
External Id: CHEMBL5303715
Name: Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV)
Source: NCGC
External Id: APP-Toga-CHIKV-nsp2-p
Name: Millipore: Percentage of residual kinase activity of PRKAA2 at 10uM relative to contr...
Source: ChEMBL
Target: 5'-AMP-activated protein kinase catalytic subunit alpha-1
External Id: CHEMBL2219380
Name: Millipore: Percentage of residual kinase activity of NUAK1 at 1uM relative to control...
Source: ChEMBL
Target: NUAK family SNF1-like kinase 1
External Id: CHEMBL2219381
Name: Millipore: Percentage of residual kinase activity of PRKAA1 at 10uM relative to contr...
Source: ChEMBL
Target: 5'-AMP-activated protein kinase catalytic subunit alpha-1
External Id: CHEMBL2219378
Name: Millipore: Percentage of residual kinase activity of PRKAA2 at 1uM relative to contro...
Source: ChEMBL
Target: 5'-AMP-activated protein kinase catalytic subunit alpha-1
External Id: CHEMBL2219379
Name: Millipore: Percentage of residual kinase activity of MAP3K5 at 10uM relative to contr...
Source: ChEMBL
Target: Mitogen-activated protein kinase kinase kinase 5
External Id: CHEMBL2218943
Name: Millipore: Percentage of residual kinase activity of ABL1 at 1uM relative to control....
Source: ChEMBL
Target: Tyrosine-protein kinase ABL1
External Id: CHEMBL2218944
Name: Millipore: Percentage of residual kinase activity of NUAK1 at 10uM relative to contro...
Source: ChEMBL
Target: NUAK family SNF1-like kinase 1
External Id: CHEMBL2219382
Name: Millipore: Percentage of residual kinase activity of MAP3K5 at 1uM relative to contro...
Source: ChEMBL
Target: Mitogen-activated protein kinase kinase kinase 5
External Id: CHEMBL2219383
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 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

sto-609
sto-609 acetic acid
sto-609 acetate

 STO609 | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the molecular formula of STO-609 acetate,7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylicacidacetate?
A: Molecular formula of STO-609 acetate,7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylicacidacetate is C19H10N2O3.
Q: What is the CAS number of STO-609 acetate,7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylicacidacetate?
A: CAS number of STO-609 acetate,7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylicacidacetate is 52029-86-4.
Q: What is the SMILES notation of STO-609 acetate,7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylicacidacetate?
A: SMILES notation of STO-609 acetate,7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylicacidacetate is O=C(O)c1ccc2c3c1cccc3c(=O)n1c3ccccc3nc21.
Q: What is the polar surface area (PSA) of STO-609 acetate,7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylicacidacetate?
A: Polar surface area (PSA) of STO-609 acetate,7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylicacidacetate is 108.97000.
Q: What is the LogP of STO-609 acetate,7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylicacidacetate?
A: LogP of STO-609 acetate,7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylicacidacetate is 3.38100.
Q: What is the boiling point of STO-609 acetate,7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylicacidacetate?
A: Boiling point of STO-609 acetate,7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylicacidacetate is 797.3ºC at 760 mmHg.
Q: What is the Chinese name of 52029-86-4?
A: Chinese name of 52029-86-4 is STO-609.
Q: What is the molecular weight of STO-609 acetate,7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylicacidacetate?
A: Molecular weight of STO-609 acetate,7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylicacidacetate is 314.29.
Q: What is the InChIKey of STO-609 acetate,7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylicacidacetate?
A: InChIKey of STO-609 acetate,7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylicacidacetate is MYKOWOGZBMOVBJ-UHFFFAOYSA-N.
Q: What is the safety information for STO-609 acetate,7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylicacidacetate?
A: Safety information for STO-609 acetate,7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylicacidacetate: 22-24/25.

 STO609factory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
Dayang Chem (Hangzhou) Co., Ltd.
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