Tetrahydroberberine

Modify Date: 2024-01-02 11:25:55

Tetrahydroberberine structure	Common Name	Tetrahydroberberine
	CAS Number	522-97-4	Molecular Weight	339.385
	Density	1.3±0.1 g/cm3	Boiling Point	476.1±45.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₂₁NO₄	Melting Point	N/A
	MSDS	N/A	Flash Point	141.1±25.9 °C

Use of Tetrahydroberberine

Tetrahydroberberine is an isoquinoline alkaloid isolated from corydalis tuber; has micromolar affinity for dopamine D(2) (pK(i) = 6.08) and 5-HT(1A) (pK(i) = 5.38) receptors but moderate to no affinity for other relevant serotonin receptors (5-HT(1B), 5-HT(1D), 5-HT(3), and 5-HT(4); pK(i) < 5.00).

Name	canadine
Synonym	More Synonyms

Description	Tetrahydroberberine is an isoquinoline alkaloid isolated from corydalis tuber; has micromolar affinity for dopamine D(2) (pK(i) = 6.08) and 5-HT(1A) (pK(i) = 5.38) receptors but moderate to no affinity for other relevant serotonin receptors (5-HT(1B), 5-HT(1D), 5-HT(3), and 5-HT(4); pK(i) < 5.00).
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Natural Products >> Alkaloid Research Areas >> Neurological Disease
References	[1]. Lee TH, et al. Tetrahydroberberine, an isoquinoline alkaloid isolated from corydalis tuber, enhances gastrointestinal motor function. J Pharmacol Exp Ther. 2011 Sep;338(3):917-24. [2]. Niwa M, et al. Dopaminergic unique affinity of tetrahydroberberine and l-tetrahydroberberine-d-camphor sulfonate. Pharmacology. 1991;43(6):329-36.

Description

Related Catalog

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor

Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor

Natural Products >> Alkaloid

Research Areas >> Neurological Disease

References

[1]. Lee TH, et al. Tetrahydroberberine, an isoquinoline alkaloid isolated from corydalis tuber, enhances gastrointestinal motor function. J Pharmacol Exp Ther. 2011 Sep;338(3):917-24.

[2]. Niwa M, et al. Dopaminergic unique affinity of tetrahydroberberine and l-tetrahydroberberine-d-camphor sulfonate. Pharmacology. 1991;43(6):329-36.

Density	1.3±0.1 g/cm3
Boiling Point	476.1±45.0 °C at 760 mmHg
Molecular Formula	C₂₀H₂₁NO₄
Molecular Weight	339.385
Flash Point	141.1±25.9 °C
Exact Mass	339.147064
PSA	40.16000
LogP	3.83
Appearance of Characters	solid \| yellow
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.656
Storage condition	2-8°C
Water Solubility	DMSO: >10 mg/mL, soluble

Hazard Codes	Xn: Harmful;
Risk Phrases	R22
Safety Phrases	36
WGK Germany	3

Precursor 4
CAS#:50-00-0 Formaldehyde CAS#:74203-90-0 (-)-canadine HCl CAS#:29074-38-2 6H-Benzo[g]-1,3... CAS#:1356336-75-8 (1S)-1-[3,4-dim...
DownStream 6
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CAS#:10134-52-8 Berberinol CAS#:47474-49-7 (S)-N-methylcanadine