Mebhydrolin

Modify Date: 2024-01-07 11:52:30

Mebhydrolin Structure
Mebhydrolin structure
Common Name Mebhydrolin
CAS Number 524-81-2 Molecular Weight 276.37600
Density 1.12 g/cm3 Boiling Point 856.1ºC at 760 mmHg
Molecular Formula C19H20N2 Melting Point N/A
MSDS N/A Flash Point 471.6ºC

 Use of Mebhydrolin


Mebhydrolin is a specific histamine H1 receptor antagonist.

 Names

Name 5-benzyl-2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indole
Synonym More Synonyms

 Mebhydrolin Biological Activity

Description Mebhydrolin is a specific histamine H1 receptor antagonist.
Related Catalog
Target

Histamine H1-receptor[1]

In Vitro Mebhydrolin is a specific histamine H1-receptor antagonist with minimal sedative properties and comparing it with the effects of chlorpromazine, the archetypical phenothiazine[1]. Mebhydrolin exerts an antihistaminic effect over the period of the ethanol interaction study[2].
References

[1]. O'Neill PA, et al. Chlorpromazine-a specific effect on breathlessness? Br J Clin Pharmacol. 1985 Jun;19(6):793-7.

[2]. Franks HM, et al. Interaction between ethanol and antihistamines: 3. Mebhydrolin. Med J Aust. 1981 Oct 31;2(9):477-9.

 Chemical & Physical Properties

Density 1.12 g/cm3
Boiling Point 856.1ºC at 760 mmHg
Molecular Formula C19H20N2
Molecular Weight 276.37600
Flash Point 471.6ºC
Exact Mass 276.16300
PSA 8.17000
LogP 3.61540
Index of Refraction 1.633
Storage condition 2-8℃

 Synthetic Route

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Mebhydrolin Structure

Mebhydrolin

CAS#:524-81-2

Literature: Yutilov; Smolyar; Volchkov Pharmaceutical Chemistry Journal, 2000 , vol. 34, # 12 p. 661 - 662

~%

Mebhydrolin Structure

Mebhydrolin

CAS#:524-81-2

Literature: Yutilov; Smolyar; Volchkov Pharmaceutical Chemistry Journal, 2000 , vol. 34, # 12 p. 661 - 662

~%

Mebhydrolin Structure

Mebhydrolin

CAS#:524-81-2

Literature: Farbenfabr. Bayer Patent: DE930444 , 1951 ; Full Text Show Details Schenley Ind. Patent: US2786059 , 1954 ; Full Text Show Details Hoerlein Chemische Berichte, 1954 , vol. 87, p. 463,467, 470

 Synonyms

Mebhydrolin
5-Benzyl-2,3,4,5-tetrahydro-2-methyl-1H-pyrido[4,3-b]indol
Mebhydrolinum [INN-Latin]
Mebhydroline
5-Benzyl-2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole
5-Benzyl-2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol
9-benzyl-3-methyl-1,2,3,4-tetrahydro-3-carboline
3-methyl-9-benzyl-1,2,3,4-tetrahydrocarboline
Mebhydroline [INN-French]
Mebhidrolina [INN-Spanish]
EINECS 208-364-4
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