Calcimycin

Modify Date: 2024-01-03 16:42:03

Calcimycin Structure
Calcimycin structure
Common Name Calcimycin
CAS Number 52665-69-7 Molecular Weight 523.621
Density 1.3±0.1 g/cm3 Boiling Point 710.3±55.0 °C at 760 mmHg
Molecular Formula C29H37N3O6 Melting Point 187-190 °C
MSDS USA Flash Point 383.4±31.5 °C

 Use of Calcimycin


Calcimycin (A23187) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). It induces Ca2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin also inhibits the activity of ATPase and uncouples oxidative phosphorylation of mammalian cells. It induces apoptosis[1][2][3][4].

 Names

Name ionophore A23187
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 710.3±55.0 °C at 760 mmHg
Melting Point 187-190 °C
Molecular Formula C29H37N3O6
Molecular Weight 523.621
Flash Point 383.4±31.5 °C
Exact Mass 523.268250
PSA 126.68000
LogP 5.66
Vapour Pressure 0.0±2.4 mmHg at 25°C
Index of Refraction 1.611
Storage condition 2-8°C

 Safety Information

Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi
Risk Phrases 36/37/38-20/21/22
Safety Phrases 26-36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS DM4676000
HS Code 29349990

 Articles113

More Articles
[Characterisation of enucleated cells apoptosis: human platelets and erythrocytes].

Ross. Fiziol. Zh. Im. I. M. Sechenova 99(1) , 92-110, (2013)

Apoptosis is a common mechanism of programmed cell death in virtually all nucleated cells. In spite of the fact that platelets and erythrocytes are the only enucleated cells in mammals they contain mo...

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

Potent trypanocidal curcumin analogs bearing a monoenone linker motif act on trypanosoma brucei by forming an adduct with trypanothione.

Mol. Pharmacol. 87(3) , 451-64, (2015)

We have previously reported that curcumin analogs with a C7 linker bearing a C4-C5 olefinic linker with a single keto group at C3 (enone linker) display midnanomolar activity against the bloodstream f...

 Synonyms

Ethacrynic acid-d5
4-Benzoxazolecarboxylic acid, 5-(methylamino)-2-[[(2S,3S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-
MFCD00151202
CALCIUM PHOSPHINATE
Lime hypophosphite
CALCIUMHYPOPHOSPHITE,PURIFIED
CALCIUM HYPOPHOSPHITE TECHNICAL
CALCIUM HYPOPHOSPHITE EXTRA PURE,DAC
5-(Methylamino)-2-({(2S,3S,8S,9R,11R)-3,9,11-trimethyl-8-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)-2-propanyl]-1,7-dioxaspiro[5.5]undec-2-yl}methyl)-1,3-benzoxazole-4-carboxylic acid
ANTIBIOTIC A 23187
Phosphinicacid,calciumsalt
Calcium bisphosphinate
5-(Methylamino)-2-({(2S,3S,8S,9R,11R)-3,9,11-trimethyl-8-[(2R)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undec-2-yl}methyl)-1,3-benzoxazole-4-carboxylic acid
Calcium hydrophosphite
EINECS 258-084-1
6S-[6a(2S*,3S*),8b(R*),9b,11a]-5-(Methylamino)-2-[[3,9,11-trimethyl-8-[1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-4-benzoxazolecarboxylic Acid
Calcimycin
A23187,free acid
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