PUROMYCIN
PUROMYCIN structure
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Common Name | PUROMYCIN | ||
|---|---|---|---|---|
| CAS Number | 53-79-2 | Molecular Weight | 471.510 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C22H29N7O5 | Melting Point | 175.5-177ºC | |
| MSDS | N/A | Flash Point | N/A | |
Use of PUROMYCINPuromycin dihydrochloride is the dihydrochloride salt of puromycin. Puromycin is an aminoglycoside antibiotic that inhibits protein synthesis. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | puromycin |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Puromycin dihydrochloride is the dihydrochloride salt of puromycin. Puromycin is an aminoglycoside antibiotic that inhibits protein synthesis. |
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| Related Catalog | |
| In Vitro | Puromycin blocks protein synthesis after aminoacyl-sRNA formation, and at the same time it leads to the accumulation of small peptides. Both of these effects appear to be due to the splitting of ribosome-bound peptidyl-sRNA,4 which results in release of incomplete peptide chains.[1]. Puromycin, an analog of the 3' end of aminoacyl-tRNA, causes premature termination of translation by being linked non-specifically to growing polypeptide chains. Puromycin has two modes of inhibitory action. The first is by acting as an acceptor substrate which attacks peptidyl-tRNA in the P site to form a nascent peptide. The second is by competing with aminoacyl-tRNA for binding to the A' site[2]. When used in minimal amounts, puromycin incorporation in neosynthesized proteins reflects directly the rate of mRNA translation in vitro. Puromycin immunodetection is an advantageous alternative to radioactive amino acid labeling. It allows the direct evaluation of translation activity in single cells by immunofluorescence microscopy and in heterogenous populations of cells by fluorescenceactivated cell sorting[3]. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Melting Point | 175.5-177ºC |
| Molecular Formula | C22H29N7O5 |
| Molecular Weight | 471.510 |
| Exact Mass | 471.223022 |
| PSA | 160.88000 |
| LogP | 0.93 |
| Index of Refraction | 1.701 |
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| RIDADR | UN 3249 |
|---|---|
| Packaging Group | III |
| Hazard Class | 6.1(b) |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 6 | |
|---|---|
| DownStream 0 | |
![3'-[(N-benzyloxycarbonyl-O-methyl-tyrosyl)-amino]-N6,N6-dimethyl-3'-deoxy-adenosine Structure](https://image.chemsrc.com/caspic/175/57182-86-2.png)
CAS#:57182-86-2![3'-[(N-tert-butoxycarbonyl-O-methyl-tyrosyl)-amino]-N6,N6-dimethyl-3'-deoxy-adenosine Structure](https://image.chemsrc.com/caspic/043/57183-05-8.png)
CAS#:57183-05-8
CAS#:67313-10-4
CAS#:2627-64-7![9-[3-(benzylamino)-3-N,2-O-carbonyl-3-deoxy-β-D-ribofuranosyl]adenine Structure](https://image.chemsrc.com/caspic/315/125084-71-1.png)
CAS#:125084-71-1
CAS#:58-60-6This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| PUROMYCIN |
| p-638 |
| Stylomycin |
| L-3'-(a-Amino-p-methoxyhydrocinnamamido)-3'-deoxy-N,N-dimethyladenosine |
| 3123l |
| (S)-3'-[[2-Amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyladenosine |
| puromycinum [INN_la] |
| 1-mm |
| 6-Dimethylamino-9-[3-deoxy-3-(p-methoxy-L-phenylalanylamino)-b-D-ribofuranosyl]-b-purine |
| cl13,900 |
| 3'-{(E)-[(2S)-2-Amino-1-hydroxy-3-(4-methoxyphenyl)propylidene]amino}-3'-deoxy-N,N-dimethyladenosine |
| 3123-L |
| 3'-(a-Amino-p-methoxyhydrocinnamamido)-3'-deoxy-N,N-dimethyladenosine |
| Stillomycin |
| achromycin |
| 3'-Deoxy-N,N-dimethyl-3'-[(O-methyl-L-tyrosyl)amino]adenosine |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What are the upstream materials of puromycin? |
| A: Related upstream materials(CAS) of puromycin: 57182-86-2;57183-05-8;67313-10-4;2627-64-7;125084-71-1;58-60-6. |
| Q: What is the molecular formula of puromycin? |
| A: Molecular formula of puromycin is C22H29N7O5. |
| Q: What is the CAS number of puromycin? |
| A: CAS number of puromycin is 53-79-2. |
| Q: What is the LogP of puromycin? |
| A: LogP of puromycin is 0.93. |
| Q: What is the polar surface area (PSA) of puromycin? |
| A: Polar surface area (PSA) of puromycin is 160.88000. |
| Q: What is the English name of puromycin? |
| A: The English name of puromycin is puromycin. |
| Q: What is the melting point of puromycin? |
| A: Melting point of puromycin is 175.5-177ºC. |
| Q: What are the uses of puromycin? |
| A: Main uses of puromycin: Puromycin dihydrochloride is the dihydrochloride salt of puromycin. Puromycin is an aminoglycoside antibiotic that inhibits protein synthesis. |
| Q: What is the molecular weight of puromycin? |
| A: Molecular weight of puromycin is 471.510. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |