Trimethyldiaminophenazathonium Chloride

Modify Date: 2026-07-01 09:12:45

Trimethyldiaminophenazathonium Chloride structure	Common Name	Trimethyldiaminophenazathonium Chloride
	CAS Number	531-55-5	Molecular Weight	305.826
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₅H₁₆ClN₃S	Melting Point	205-210 °C (dec.)(lit.)
	MSDS	Chinese USA	Flash Point	N/A

Use of Trimethyldiaminophenazathonium Chloride

Azure B is a cationic dye and the major metabolite of Methylene blue. Azure B is used in making Azure eosin stains for blood smear staining. Azure B is a high-potency, selective and reversible inhibitor of monoamine oxidases (MAO)-A, with IC50s of 11 and 968 nM for recombinant human MAO-A and MAO-B, respectively. Azure B possesses significant antidepressant-like effects[1][2].

Name	azure B
Synonym	More Synonyms

Description	Azure B is a cationic dye and the major metabolite of Methylene blue. Azure B is used in making Azure eosin stains for blood smear staining. Azure B is a high-potency, selective and reversible inhibitor of monoamine oxidases (MAO)-A, with IC50s of 11 and 968 nM for recombinant human MAO-A and MAO-B, respectively. Azure B possesses significant antidepressant-like effects[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Neurological Disease
In Vivo	Azure B (4-30 mg/kg; i.p.; once) decreases immobility in the forced swim test (FST)[1].
References	[1]. Löhr W,et al. The azure dyes: their purification and physicochemical properties. II. Purification of azure B. Stain Technol. 1975 May;50(3):149-56. [2]. Delport A, et al. Azure B and a synthetic structural analogue of methylene blue, ethylthioninium chloride, present with antidepressant-like properties. Life Sci. 2014 Nov 11;117(2):56-66.

Melting Point	205-210 °C (dec.)(lit.)
Molecular Formula	C₁₅H₁₆ClN₃S
Molecular Weight	305.826
Exact Mass	305.075348
PSA	56.17000
InChIKey	DNDJEIWCTMMZBX-UHFFFAOYSA-N
SMILES	CNc1ccc2nc3ccc(=[N+](C)C)cc-3sc2c1.[Cl-]

Trimethyldiaminophenazathonium Chloride MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SO5550000

CHEMICAL NAME :: 3H-Phenothiazine, 3-(dimethylamino)-7-(methylimino)-, hydrochloride

CAS REGISTRY NUMBER :: 531-55-5

LAST UPDATED :: 199504

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C15-H16-N3-S.Cl

MOLECULAR WEIGHT :: 305.85

WISWESSER LINE NOTATION :: T C666 BS EY INJ EUN1 MN1&1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 65 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 20 umol/L/5H (Continuous)

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 1,27,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - T1407 No. of Facilities: 150 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 664 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T1407 No. of Facilities: 101 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 3055 (estimated) No. of Female Employees: 2122 (estimated)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	SO5550000
HS Code	2934300000

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Precursor 3
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DownStream 0

HS Code	2934300000
Summary	2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Trimethylthionine chloride

N,N-Dimethyl-7-(methylamino)-3H-phenothiazin-3-iminium chloride

Methyleneazure

3-Methylamino-7-dimethylaminophenazathonium Chloride

N,N,N'-Trimethylthionin

EINECS 208-511-2

3-(Dimethylamino)-7-(methylamino)phenothiazin-5-ium chloride

Methanaminium, N-methyl-N-[7-(methylamino)-3H-phenothiazin-3-ylidene]-, chloride (1:1)

Trimethyldiaminophenazathonium Chloride

Azure B eosinate

Azure B,Certified

Azure I

Phenothiazinium, 3-(dimethylamino)-7-(methylamino)-, chloride (1:1)

Phenothiazin-5-ium, 3- (dimethylamino)-7-(methylamino)-, chloride

MFCD00011935

AZUR I

dimethyl-[7-(methylamino)phenothiazin-3-ylidene]azanium,chloride

Azure B

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Trimethyldiaminophenazathonium Chloride

Use of Trimethyldiaminophenazathonium Chloride

Names