BPH-1358

Modify Date: 2024-01-10 19:13:07

BPH-1358 Structure
BPH-1358 structure
 Common Name BPH-1358
CAS Number 5352-53-4 Molecular Weight 565.06500
Density 1.32g/cm3 Boiling Point N/A
Molecular Formula C32H30Cl2N6O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of BPH-1358


BPH-1358 (NSC50460) is a potent human farnesyl diphosphate synthase (FPPS) and undecaprenyl diphosphate synthase (UPPS) inhibitor with IC50s of 1.8 μM and 110 nM, respectively, and is active against S. aureus in vitro (MIC ~250 ng/mL)[1][2].

 Names

Name N-[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-4-[4-[[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]carbamoyl]phenyl]benzamide,hydrochloride

 BPH-1358 Biological Activity

Description BPH-1358 (NSC50460) is a potent human farnesyl diphosphate synthase (FPPS) and undecaprenyl diphosphate synthase (UPPS) inhibitor with IC50s of 1.8 μM and 110 nM, respectively, and is active against S. aureus in vitro (MIC ~250 ng/mL)[1][2].
Related Catalog
Target

IC50: 1.8 μM (human bisphosphonate farnesyl diphosphate synthase)[1]; 100 nM (undecaprenyl diphosphate synthase)[2]

In Vitro BPH-1358 is the most potent inhibitor of both E. coli UPPS (EcUPPS) as well as S. aureus UPPS (SaUPPS) with an IC50 of 110 nM. BPH-1358 against E. coli and S. aureus with EC50 of 300 nM and 290 nM, respectively[1].
In Vivo BPH-1358 is active against S. aureus in vivo (20/20 mice survived in an i.p. infection model with a MRSA strain)[1].
References

[1]. Zhu W, et al. Antibacterial drug leads: DNA and enzyme multitargeting. J Med Chem. 2015 Feb 12;58(3):1215-27.

[2]. Liu YL, et al. Farnesyl diphosphate synthase inhibitors with unique ligand-binding geometries. ACS Med Chem Lett. 2015 Jan 29;6(3):349-54.

 Chemical & Physical Properties

Density 1.32g/cm3
Molecular Formula C32H30Cl2N6O2
Molecular Weight 565.06500
Exact Mass 564.20400
PSA 106.98000
LogP 5.03460
Index of Refraction 1.704
Top Suppliers:I want be here

Get all suppliers and price by the below link:

BPH-1358 suppliers

BPH-1358 price

Related Compounds: More...
BPH-1358 free base
801985-13-7
BPH-1086
1226901-43-4
BPH-715
1059677-23-4
{Co(dimethylglyoxime)3(BPh)2}BF4
100113-33-5
{Co(diphenylglyoxime)3(BPh)2}BF4
100113-37-9
{Co(cyclohexanedione dioxime)3(BPh)2}BF4
100113-35-7
2,3-dichloro-6-fluorophenol
886497-60-5
1-phosphono-4-(3-phenoxyphenyl) butylsulfonic acid tripotassium salt
157124-84-0
L-p-bromophenylalanine methyl ester
99359-33-8
Chemsrc provides BPH-1358(CAS#:5352-53-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of BPH-1358 are included as well.>> amp version: BPH-1358

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved