BPH-1358 free base
Modify Date: 2024-01-02 23:30:08
BPH-1358 free base structure
|
Common Name | BPH-1358 free base | ||
|---|---|---|---|---|
| CAS Number | 801985-13-7 | Molecular Weight | 528.60 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C32H28N6O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BPH-1358 free baseBPH-1358 free base (NSC50460 free base) is a potent human farnesyl diphosphate synthase (FPPS) and undecaprenyl diphosphate synthase (UPPS) inhibitor with IC50s of 1.8 μM and 110 nM, respectively, and is active against S. aureus in vitro (MIC ~250 ng/mL)[1][2]. |
| Name | BPH-1358 free base |
|---|
| Description | BPH-1358 free base (NSC50460 free base) is a potent human farnesyl diphosphate synthase (FPPS) and undecaprenyl diphosphate synthase (UPPS) inhibitor with IC50s of 1.8 μM and 110 nM, respectively, and is active against S. aureus in vitro (MIC ~250 ng/mL)[1][2]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 1.8 μM (human bisphosphonate farnesyl diphosphate synthase)[1]; 100 nM (undecaprenyl diphosphate synthase)[2] |
| In Vitro | BPH-1358 is the most potent inhibitor of both E. coli UPPS (EcUPPS) as well as S. aureus UPPS (SaUPPS) with an IC50 of 110 nM. BPH-1358 against E. coli and S. aureus with EC50 of 300 nM and 290 nM, respectively[1]. |
| In Vivo | BPH-1358 is active against S. aureus in vivo (20/20 mice survived in an i.p. infection model with a MRSA strain)[1]. |
| References |
| Molecular Formula | C32H28N6O2 |
|---|---|
| Molecular Weight | 528.60 |