3-Hydroxy-L-(2,5,6-2H3)tyrosine

Modify Date: 2024-01-23 19:26:58

3-Hydroxy-L-(2,5,6-2H3)tyrosine structure	Common Name	3-Hydroxy-L-(2,5,6-2H3)tyrosine
	CAS Number	53587-29-4	Molecular Weight	200.20600
	Density	1.49g/cm3	Boiling Point	448.4ºC at 760 mmHg
	Molecular Formula	C₉H₈D₃NO₄	Melting Point	292ºC (dec.)(lit.)
	MSDS	Chinese USA	Flash Point	225ºC
	Symbol	GHS07	Signal Word	Warning

Use of 3-Hydroxy-L-(2,5,6-2H3)tyrosine

L-DOPA-2,5,6-d3 (Levodopa-2,5,6-d3) is the deuterium labeled L-DOPA. L-DOPA (Levodopa) is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA can cross the blood-brain barrier and is converted into dopamine in the brain[1][2][3].

Name	(2S)-2-amino-3-(2,3,6-trideuterio-4,5-dihydroxyphenyl)propanoic acid
Synonym	More Synonyms

Description	L-DOPA-2,5,6-d3 (Levodopa-2,5,6-d3) is the deuterium labeled L-DOPA. L-DOPA (Levodopa) is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA can cross the blood-brain barrier and is converted into dopamine in the brain[1][2][3].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Hyland K, et al. Aromatic L-amino acid decarboxylase deficiency: diagnostic methodology. Clin Chem. 1992 Dec;38(12):2405-10. [3]. Merims D, et al. Dopamine dysregulation syndrome, addiction and behavioral changes in Parkinson's disease. Parkinsonism Relat Disord. 2008;14(4):273-80. Epub 2007 Nov 7. [4]. Perez-Pardo P, et al. Additive Effects of Levodopa and a Neurorestorative Diet in a Mouse Model of Parkinson's Disease. Front Aging Neurosci. 2018 Aug 3;10:237. [5]. Park HJ, et al. Anti-allodynic effects of levodopa in neuropathic rats. Yonsei Med J. 2013 Mar 1;54(2):330-5.

Density	1.49g/cm3
Boiling Point	448.4ºC at 760 mmHg
Melting Point	292ºC (dec.)(lit.)
Molecular Formula	C₉H₈D₃NO₄
Molecular Weight	200.20600
Flash Point	225ºC
Exact Mass	200.08800
PSA	103.78000
LogP	0.75250
Index of Refraction	1.654

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn
Risk Phrases	R22
Safety Phrases	26-36
RIDADR	NONH for all modes of transport

Restriction of dopamine signaling to the dorsolateral striatum is sufficient for many cognitive behaviors.

Proc. Natl. Acad. Sci. U. S. A. 106(34) , 14664-9, (2009)

The striatum is a vital substrate for performance, procedural memory, and learning. The ventral and medial striatum are thought to be critical for acquisition of tasks while the dorsolateral striatum ...

Capsules from pathogenic and non-pathogenic Cryptococcus spp. manifest significant differences in structure and ability to protect against phagocytic cells.

PLoS ONE 7 , e29561, (2012)

Capsule production is common among bacterial species, but relatively rare in eukaryotic microorganisms. Members of the fungal Cryptococcus genus are known to produce capsules, which are major determin...

L-DOPA-2,5,6-d3

L-Tyrosine-2,5,6-d, 3-hydroxy-

Dopa-phenyl-d3

MFCD00075014

L-Dihydroxyphenylalanine-2H3

3-Hydroxy-L-(2,5,6-H)tyrosine

2,3,6-trideuterio-4,5-dihydroxy-phenylalanine

3-Hydroxy-L-(2,5,6-2H3)tyrosine

Use of 3-Hydroxy-L-(2,5,6-2H3)tyrosine

Names

3-Hydroxy-L-(2,5,6-2H3)tyrosine Biological Activity

Chemical & Physical Properties

Safety Information

Articles2

Synonyms