27468-20-8

27468-20-8 structure

Name: Deoxyneocryptotanshinone
Chemical Name: Deoxyneocryptotanshinone
CAS Number: 27468-20-8
Molecular Formula: C₁₉H₂₂O₃
Molecular Weight: 298.376
Catalog: Natural product Moss
Create Date: 2017-03-27 11:31:55
Modify Date: 2024-01-17 17:59:24
Deoxyneocryptotanshinone, a natural tanshinone, is a high affinity BACE1 (Beta-secretase) inhibitor with an IC50 value of 11.53 μM. Deoxyneocryptotanshinone shows a promising dose-dependent inhibition of protein tyrosine phosphatase 1B (PTP1B) with an IC50 value of 133.5 μM. Deoxyneocryptotanshinone can be used for Alzheimer's disease research[1][2].

Name	Deoxyneocryptotanshinone
Synonyms	3-Hydroxy-2-isopropyl-8,8-dimethyl-5,6,7,8-tetrahydro-1,4-phenanthrenedione 1,4-Phenanthrenedione, 5,6,7,8-tetrahydro-3-hydroxy-8,8-dimethyl-2-(1-methylethyl)-

Description	Deoxyneocryptotanshinone, a natural tanshinone, is a high affinity BACE1 (Beta-secretase) inhibitor with an IC50 value of 11.53 μM. Deoxyneocryptotanshinone shows a promising dose-dependent inhibition of protein tyrosine phosphatase 1B (PTP1B) with an IC50 value of 133.5 μM. Deoxyneocryptotanshinone can be used for Alzheimer's disease research[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Beta-secretase Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase Research Areas >> Neurological Disease
Target	IC50: 11.53 μM (BACE1)[1] and 133.5 μM (PTP1B)[2]
References	[1]. Ting Yu, et al. Computational insights into β-site amyloid precursor protein enzyme 1 (BACE1) inhibition by tanshinones and salvianolic acids from Salvia miltiorrhiza via molecular docking simulations. Comput Biol Chem. 2018 Jun;74:273-285. [2]. Da Hye Kim, et al. Characterization of the inhibitory activity of natural tanshinones from Salvia miltiorrhiza roots on protein tyrosine phosphatase 1B. Chem Biol Interact. 2017 Dec 25;278:65-73.

Hazard Codes	Xi