5'-Iodoresiniferatoxin

• 常用名: 5'-Iodoresiniferatoxin
• 英文名: 5'-Iodoresiniferatoxin
• CAS号: 535974-91-5
• 分子量: 754.60
• 密度: 1.6±0.1 g/cm3
• 沸点: 782.4±60.0 °C at 760 mmHg
• 分子式: C₃₇H₃₉IO₉
• 熔点: N/A
• 闪点: 427.0±32.9 °C

5'-Iodoresiniferatoxin用途

5-Iodoresiniferatoxin (I-RTX) 是一种选择性的 TRPV1 拮抗剂,对大鼠和人类受体的 IC50 分别为 0.7 和 5.4 nM。5-Iodoresiniferatoxin 会在体内诱导 TRPV1 依赖性低温。

5'-Iodoresiniferatoxin名称

• 英文名: i-rtx

5'-Iodoresiniferatoxin生物活性

• 描述: 5-Iodoresiniferatoxin (I-RTX) 是一种选择性的 TRPV1 拮抗剂,对大鼠和人类受体的 IC50 分别为 0.7 和 5.4 nM。5-Iodoresiniferatoxin 会在体内诱导 TRPV1 依赖性低温。
• 相关类别:
  信号通路 >> 跨膜转运 >> TRP频道
  研究领域 >> 神经疾病
• 靶点实验:

  rTRPV1:0.7 nM (IC50)

  hTRPV1:5.4 nM (IC50)

• 参考文献:

  [1]. Seabrook GR, et, al. Functional properties of the high-affinity TRPV1 (VR1) vanilloid receptor antagonist (4-hydroxy-5-iodo-3-methoxyphenylacetate ester) iodo-resiniferatoxin. J Pharmacol Exp Ther. 2002 Dec;303(3):1052-60.

  [2]. Shimizu I, et, al. 5-Iodoresiniferatoxin evokes hypothermia in mice and is a partial transient receptor potential vanilloid 1 agonist in vitro. J Pharmacol Exp Ther. 2005 Sep;314(3):1378-85.

5'-Iodoresiniferatoxin物理化学性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 782.4±60.0 °C at 760 mmHg
• 分子式: C₃₇H₃₉IO₉
• 分子量: 754.60
• 闪点: 427.0±32.9 °C
• 精确质量: 754.163879
• PSA: 120.75000
• LogP: 6.65
• InChIKey: TZUJORCXGLGWDV-OXSIMREDSA-N
• SMILES: C=C(C)C12CC(C)C34OC(Cc5ccccc5)(OC1C3C=C(COC(=O)Cc1cc(I)c(O)c(OC)c1)CC1(O)C(=O)C(C)=CC14)O2
• 蒸汽压: 0.0±2.8 mmHg at 25°C
• 折射率: 1.671

5'-Iodoresiniferatoxin靶点实验

查看更多实验

实验名称：Displacement of [3H]RTX from human TRPV1 expressed in CHO cells 来源：ChEMBL 靶标：Transient receptor potential cation channel subfamily V member 1 External Id：CHEMBL2428534

实验名称：Agonist activity at human TRPV1 expressed in CHO cells assessed as stimulation of Ca2... 来源：ChEMBL 靶标：Transient receptor potential cation channel subfamily V member 1 External Id：CHEMBL2428533

实验名称：Agonist activity at rat TRPV1 receptor expressed in CHO cells assessed as calcium 45 ... 来源：ChEMBL 靶标：Transient receptor potential cation channel subfamily V member 1 External Id：CHEMBL926239

实验名称：Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of R... 来源：ChEMBL 靶标：Transient receptor potential cation channel subfamily V member 1 External Id：CHEMBL3102685

实验名称：Agonist activity at human TRPV1 expressed in CHO cells assessed as 45Ca2+ uptake afte... 来源：ChEMBL 靶标：Transient receptor potential cation channel subfamily V member 1 External Id：CHEMBL3102686

实验名称：Displacement of [3H]RTX from human TRPV1 expressed in CHO cells after 60 mins by liqu... 来源：ChEMBL 靶标：Transient receptor potential cation channel subfamily V member 1 External Id：CHEMBL3100277

实验名称：Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of c... 来源：ChEMBL 靶标：Transient receptor potential cation channel subfamily V member 1 External Id：CHEMBL2428531

实验名称：Human TRPV1 (Transient Receptor Potential channels) 来源：IUPHAR-DB 靶标：TRPV1 (Transient Receptor Potential channels) [Homo sapiens] External Id：507_Human

实验名称：Inhibition of rat brain FAAH assessed by measuring [14C]anandamide hydrolysis at 50 u... 来源：ChEMBL 靶标：Fatty-acid amide hydrolase 1 External Id：CHEMBL902592

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5'-Iodoresiniferatoxin英文别名

• [(1R,2R,6R,10S,11R,15R,17R)-13-Benzyl-6-hydroxy-15-isopropenyl-4,17-dimethyl-5-oxo-12,14,18-trioxapentacyclo[11.4.1.0.0.0]octadeca-3,8-dien-8-yl]methyl (4-hydroxy-3-iodo-5-methoxyphe nyl)acetate
• 5-I-RTX
• 5'-Iodoresiniferatoxin
• Benzeneacetic acid, 4-hydroxy-3-iodo-5-methoxy-, [(3aR,3bS,6aR,9aR,9bR,10R,11aR)-3a,3b,6,6a,9a,10,11,11a-octahydro-6a-hydroxy-8,10-dimethyl-11a-(1-methylethenyl)-7-oxo-2-(phenylmethyl)-7H-2,9b-epoxyazuleno[4',5':5,6]benzo[1,2-d]-1,3-dioxol-5-yl]methyl ester
• [(1R,2R,6R,10S,11R,15R,17R)-13-Benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-(prop-1-en-2-yl)-12,14,18-trioxapentacyclo[11.4.1.0.0.0]octadeca-3,8-dien-8-yl]methyl (4-hydroxy-3-iodo-5-methoxyphenyl)acetate