CP-724714

Modify Date: 2024-01-09 19:21:12

CP-724714 Structure
CP-724714 structure
Common Name CP-724714
CAS Number 537705-08-1 Molecular Weight 469.535
Density 1.3±0.1 g/cm3 Boiling Point 687.3±55.0 °C at 760 mmHg
Molecular Formula C27H27N5O3 Melting Point N/A
MSDS N/A Flash Point 369.5±31.5 °C

 Use of CP-724714


(E/Z)-CP-724714 is a racemic compound of (E)-CP-724714 and (Z)-CP-724714 isomers. CP-724714 is a potent and selective orally active ErbB2 (HER2) inhibitor[1].

 Names

Name (E)-Ethyl (3-(4-((3-methyl-4-((6-methylpyridin-3-yl)oxy)phenyl)amino)quinazolin-6-yl)allyl)carbamate
Synonym More Synonyms

 CP-724714 Biological Activity

Description (E/Z)-CP-724714 is a racemic compound of (E)-CP-724714 and (Z)-CP-724714 isomers. CP-724714 is a potent and selective orally active ErbB2 (HER2) inhibitor[1].
Related Catalog
Target

HER2

References

[1]. Jani JP, et al. Discovery and pharmacologic characterization of CP-724,714, a selective ErbB2 tyrosine kinase inhibitor. Cancer Res, 2007, 67(20), 9887-9893.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 687.3±55.0 °C at 760 mmHg
Molecular Formula C27H27N5O3
Molecular Weight 469.535
Flash Point 369.5±31.5 °C
Exact Mass 469.211395
PSA 98.26000
LogP 4.05
Vapour Pressure 0.0±2.1 mmHg at 25°C
Index of Refraction 1.663
Storage condition -20°C

 Safety Information

HS Code 2933990090

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

Kumarin
2-methoxy-N-(3-(4-((3-methyl-4-((6-methyl-3-pyridinyl)oxy)phenyl)amino)-6-quinazolinyl)-2-propenyl)acetamide
Rattex
CUMARIN
(E)-Ethyl (3-(4-((3-methyl-4-((6-methylpyridin-3-yl)-oxy)phenyl)amino)quinazolin-6-yl)allyl)carbamate
COUMARINE
chromen-2-one
2-Methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide
2-Methoxy-N-{(2E)-3-[4-({3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl}amino)-6-quinazolinyl]-2-propen-1-yl}acetamide
Acetamide, 2-methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]-
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