Letosteine

Modify Date: 2024-01-11 12:28:19

Letosteine Structure
Letosteine structure
Common Name Letosteine
CAS Number 53943-88-7 Molecular Weight 279.38
Density 1.284 g/cm3 Boiling Point 470ºC at 760 mmHg
Molecular Formula C10H17NO4S2 Melting Point 142ºC
MSDS N/A Flash Point 238.1ºC

 Use of Letosteine


Letosteine is an orally active, potent and safe expectorant. Letosteine dissolves bronchial mucus and reduces respiratory inflammation symptoms, and restores gas exchanges and natural defense mechanisms in the lung. Letosteine can be used for acute or chronic respiratory diseases (such as bronchopneumopathies) research[1][2][3].

 Names

Name 2-[2-(2-ethoxy-2-oxoethyl)sulfanylethyl]-1,3-thiazolidine-4-carboxylic acid
Synonym More Synonyms

 Letosteine Biological Activity

Description Letosteine is an orally active, potent and safe expectorant. Letosteine dissolves bronchial mucus and reduces respiratory inflammation symptoms, and restores gas exchanges and natural defense mechanisms in the lung. Letosteine can be used for acute or chronic respiratory diseases (such as bronchopneumopathies) research[1][2][3].
Related Catalog
In Vivo Letosteine (Sprague-Dawley rats, 20 mg/kg, IV or Orally, once) is rapidly excreted with mainly in urine[4]. Animal Model: Sprague-Dawley rats Dosage: 20 mg/kg Administration: IV or Orally, once Result: Rapidly was excreted with mainly in urine. More than 86% of the administered [14C]-radioactivity was recovered in urine within 72 h, 5-7% of the administered [14C]-radioactivity was recovered as 14CO2 in the expired air.
References

[1]. [1]Jia L. Letosteine. John Wiley & Sons, Ltd, 2014.

[2]. [2] Macquet V, et al. A new contribution to the treatment of chronic bronchopneumopathies: letosteine. Lille Med. 1979;24(9):735-738.

[3]. [3] Zhou Y, et al. Efficacy and safety of letosteine in the treatment of sputum thickening and expectoration difficulty in patients with respiratory diseases: a multicenter, randomized, double-masked, double dummy, positive drug parallel controlled trial. Pharmazie. 2014;69(11):842-849.

[4]. [4] Gachon F, et al. Disposition and metabolism of letosteine in rats. Drug Metab Dispos. 1988;16(6):853-857.

 Chemical & Physical Properties

Density 1.284 g/cm3
Boiling Point 470ºC at 760 mmHg
Melting Point 142ºC
Molecular Formula C10H17NO4S2
Molecular Weight 279.38
Flash Point 238.1ºC
Exact Mass 279.06000
PSA 126.23000
LogP 1.11730
Index of Refraction 1.547

 Safety Information

Hazard Codes Xn
HS Code 2934999090

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

Viscotiol
Letosteine
Letosteinum
Letosteina