(+)-gamma-Tocopherol

Modify Date: 2025-08-20 11:26:05

(+)-gamma-Tocopherol Structure
(+)-gamma-Tocopherol structure
 Common Name (+)-gamma-Tocopherol
CAS Number 54-28-4 Molecular Weight 416.68000
Density 0.933g/cm3 Boiling Point 200 °C (0.1 mmHg)
Molecular Formula C28H48O2 Melting Point N/A
MSDS Chinese USA Flash Point 206ºC
Symbol GHS02 GHS06 GHS08
GHS02, GHS06, GHS08		 Signal Word Danger

 Use of (+)-gamma-Tocopherol


γ-Tocopherol (D-γ-Tocopherol) is a potent cyclooxygenase (COX) inhibitor. γ-Tocopherol is a naturally occurring form of Vitamin E in many plant seeds, such as corn oil and soybeans. γ-Tocopherol possesses antiinflammatory properties and anti-cancer activity[1].

 Names

Name γ-tocopherol
Synonym More Synonyms

 (+)-gamma-Tocopherol Biological Activity

Description γ-Tocopherol (D-γ-Tocopherol) is a potent cyclooxygenase (COX) inhibitor. γ-Tocopherol is a naturally occurring form of Vitamin E in many plant seeds, such as corn oil and soybeans. γ-Tocopherol possesses antiinflammatory properties and anti-cancer activity[1].
Related Catalog
Target

Cyclooxygenase

In Vitro γ-Tocopherol (D-γ-Tocopherol) is well absorbed and accumulates to a significant degree in some human tissues; it is metabolized, however, largely to 2,7,8-trimethyl-2-(beta-carboxyethyl)-6-hydroxychroman (gamma-CEHC), which is mainly excreted in the urine[1]. Plasma concentrations of γ-Tocopherol (D-γ-Tocopherol) are inversely associated with the incidence of cardiovascular disease and prostate cancer[1].
References

[1]. Q Jiang, et al. Gamma-Tocopherol, the Major Form of Vitamin E in the US Diet, Deserves More Attention. Am J Clin Nutr. 2001 Dec;74(6):714-22.

 Chemical & Physical Properties

Density 0.933g/cm3
Boiling Point 200 °C (0.1 mmHg)
Molecular Formula C28H48O2
Molecular Weight 416.68000
Flash Point 206ºC
Exact Mass 416.36500
PSA 29.46000
LogP 8.53180
Index of Refraction n20/D 1.505
InChIKey QUEDXNHFTDJVIY-DQCZWYHMSA-N
SMILES Cc1c(O)cc2c(c1C)OC(C)(CCCC(C)CCCC(C)CCCC(C)C)CC2
Storage condition 2~8°C

 Safety Information

Symbol GHS02 GHS06 GHS08
GHS02, GHS06, GHS08
Signal Word Danger
Hazard Statements H225-H301 + H311 + H331-H370
Precautionary Statements P210-P260-P280-P301 + P310-P311
Personal Protective Equipment Eyeshields;Gloves
Hazard Codes F
Risk Phrases 11-23/24/25-39/23/24/25
Safety Phrases S24/25
RIDADR UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 3
HS Code 2932999099

 Synthetic Route

 Customs

HS Code 2932999099
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles8

More Articles
Fine-scale thermal adaptation in a green turtle nesting population.

Proc. Biol. Sci. 279(1731) , 1077-84, (2012)

The effect of climate warming on the reproductive success of ectothermic animals is currently a subject of major conservation concern. However, for many threatened species, we still know surprisingly ...

Accumulation of γ- rather than α-tocopherol alters ethylene signaling gene expression in the vte4 mutant of Arabidopsis thaliana.

Plant Cell Physiol. 52 , 1389-1400, (2011)

Tocopherols are antioxidants found in chloroplasts of leaves, and it is a matter of current debate whether or not they can affect signaling and gene expression in plant cells. For insight into the pos...

Vitamin E isoforms directly bind PKCα and differentially regulate activation of PKCα.

Biochem. J. 441(1) , 189-198, (2012)

Vitamin E isoforms have opposing regulatory effects on leucocyte recruitment during inflammation. Furthermore, in vitro, vitamin E isoforms have opposing effects on leucocyte migration across endothel...

 (+)-gamma-TocopherolBioassay

View more

Name: insulin secretion from INS-1E cells in the presence of 5 mM glucose-screen
Source: 846
Target: N/A
External Id: 5mMGluc_INS1E_InsulinRelease_40mMGluc_SP
Name: HT-29 viability from Cell TiterGlo-IC50
Source: 846
Target: N/A
External Id: Basal_Viability_ATP_HT-29_CRC
Name: HCT116 viability from Cell TiterGlo-IC50
Source: 846
Target: N/A
External Id: Basal_Viability_ATP_HCT116_CRC
Name: qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signa...
Source: 824
Target: AR protein [Homo sapiens]
External Id: MDAN535
Name: Colo320 viability from Cell TiterGlo-IC50
Source: 846
Target: N/A
External Id: Basal_Viability_ATP_Colo_320_CRC
Name: Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu...
Source: NCGC
External Id: CYP3A4437
Name: VEGF stimulated ADSC/ECFC co-culture CD31-stained tube area decrease-IC50
Source: 846
Target: N/A
External Id: VEGF_ADSC_ECFC_Angio_CD31_TubeArea_CRC
Name: qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in...
Source: NCGC
Target: TDP1 protein [Homo sapiens]
External Id: TDP1100
Name: Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu...
Source: NCGC
External Id: CYP2D6395
Name: qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in...
Source: NCGC
Target: TDP1 protein [Homo sapiens]
External Id: TDP1101
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 Synonyms

EINECS 200-201-5
D-gamma-Tocopherol
MFCD00066529
D-γ-Tocopherol
gamma-tocopherol
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