Dithiobiuret

Modify Date: 2025-08-21 18:25:15

Dithiobiuret Structure
Dithiobiuret structure
 Common Name Dithiobiuret
CAS Number 541-53-7 Molecular Weight 135.21100
Density 1.541g/cm3 Boiling Point 272.1ºC at 760mmHg
Molecular Formula C2H5N3S2 Melting Point 181 °C
MSDS Chinese USA Flash Point 118.3ºC
Symbol GHS06
GHS06		 Signal Word Danger

 Names

Name carbamothioylthiourea
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.541g/cm3
Boiling Point 272.1ºC at 760mmHg
Melting Point 181 °C
Molecular Formula C2H5N3S2
Molecular Weight 135.21100
Flash Point 118.3ºC
Exact Mass 134.99200
PSA 128.25000
LogP 0.85470
Appearance of Characters solid
Index of Refraction 1.51

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
EC1575000
CHEMICAL NAME :
Biuret, 2,4-dithio-
CAS REGISTRY NUMBER :
541-53-7
LAST UPDATED :
199801
DATA ITEMS CITED :
10
MOLECULAR FORMULA :
C2-H5-N3-S2
MOLECULAR WEIGHT :
135.22
WISWESSER LINE NOTATION :
SUYZMYZUS

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 90,260,1947
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
29 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - chromodacryorrhea Behavioral - changes in motor activity (specific assay) Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 57,63,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Lungs, Thorax, or Respiration - cyanosis Endocrine - hyperglycemia
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 93,93,1948 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7 mg/kg/7D-I
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle weakness Related to Chronic Data - death
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 57,63,1981
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
15 mg/kg/3D-I
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979- Volume(issue)/page/year: 13,331,1992
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
84 mg/kg/12D-I
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - food intake (animal) Kidney, Ureter, Bladder - other changes
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 93,93,1948

 Safety Information

Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H300-H310-H330
Precautionary Statements P260-P264-P280-P284-P302 + P350-P310
Personal Protective Equipment Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes T+:Verytoxic;
Risk Phrases R26/27/28
Safety Phrases S22-S28-S36/37-S45
RIDADR UN 2811 6.1/PG 1
WGK Germany 3
RTECS EC1575000
Packaging Group I
Hazard Class 6.1

 Synthetic Route

1-propylpiperazine structure

1-propylpiperazine

CAS#:21867-64-1

N,N-Dimethylthiocarbamoyl Isothiocyanate structure

N,N-Dimethylthi...

CAS#:30013-32-2

~%

Dithiobiuret Structure

Dithiobiuret

CAS#:541-53-7

Literature: US3944670 A1, ;
N,N-Dimethylthiocarbamoyl Isothiocyanate structure

N,N-Dimethylthi...

CAS#:30013-32-2

N,N,N′-trimethylethylenediamine structure

N,N,N′-trimethy...

CAS#:142-25-6

~%

Dithiobiuret Structure

Dithiobiuret

CAS#:541-53-7

Literature: US3944670 A1, ;
N/A structure

N/A

CAS#:127099-85-8

~%

Dithiobiuret Structure

Dithiobiuret

CAS#:541-53-7

Literature: US2410862 , ; US2371112 , ;
sodiumdicyanamide structure

sodiumdicyanamide

CAS#:1934-75-4

~%

Dithiobiuret Structure

Dithiobiuret

CAS#:541-53-7

Literature: Cyanamid New Prod. Bull. Collective Vol. II, New York 1950,S. 83
N/A structure

N/A

CAS#:127099-85-8

~%

Amidinothiourea structure

Amidinothiourea

CAS#:2114-02-5

Dithiobiuret Structure

Dithiobiuret

CAS#:541-53-7

Literature: Organic Syntheses, , vol. 35, p. 69
N/A structure

N/A

CAS#:31111-24-7

~%

Dithiobiuret Structure

Dithiobiuret

CAS#:541-53-7

Literature: Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 16, p. 396 - 398
1-t-Butyl-4-S-t-butyliso-2-thiobiuret structure

1-t-Butyl-4-S-t...

CAS#:67754-13-6

~%

Dithiobiuret Structure

Dithiobiuret

CAS#:541-53-7

Literature: Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 16, p. 396 - 398

 Articles23

More Articles
Temporal analysis of dithiobiuret neurotoxicity in rats and assessment of potential nonneural causes.

Toxicol. Appl. Pharmacol. 91(2) , 212-21, (1987)

To evaluate the hypothesis that depressed neuromuscular transmission causes dithiobiuret (DTB)-induced muscle weakness in rats, the temporal development of impaired treadmill performance and deficits ...

Voltage clamp analysis reveals multiple populations of quanta released at neuromuscular junctions of rats treated with 2,4-dithiobiuret.

J. Pharmacol. Exp. Ther. 256(1) , 159-63, (1991)

Rats treated with small daily doses of 2,4-dithiobiuret (DTB) develop a delayed onset neuromuscular weakness after 4-6 days of treatment. Analysis of quantal release using nerve-muscle preparations ta...

Differential effects of 2,4-dithiobiuret on the synthesis and release of acetylcholine and dopamine from rat pheochromocytoma (PC12) cells.

J. Pharmacol. Exp. Ther. 275(3) , 1453-62, (1995)

Chronic administration of 2,4-dithiobiuret (DTB), causes delayed-onset neuromuscular weakness in rats. This effect results from inhibition of quantal release of acetylcholine (ACh) from motor nerve te...

 Synonyms

Imidodicarbonimidothioic diamide
Thioimidodicarbonic diamide
EINECS 208-784-8
2,4-dithiobiuret
Biuret,dithio
Dithiobiuret
Imidodicarbonodithioic diamide
Dithioallophanimidic acid
dithiobeulet
MFCD00037832
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.
Top Suppliers:I want be here

Get all suppliers and price by the below link:

Dithiobiuret suppliers

Dithiobiuret price

Related Compounds: More...
Phenyldithiobiuret
6635-73-0
methyl dithiobiuret
6939-45-3
Propyliden-dithiobiuret
5333-35-7
1,5-diphenyldithiobiuret
33951-45-0
1-Butyl-2,4-dithiobiuret
98275-27-5
1,1Dimethyl-dithiobiuret
14812-36-3
1-Ethyl-2,4-dithiobiuret
5863-82-1
1-Cyclohexyl-dithiobiuret
31253-76-6
1,5-Dianilino-dithiobiuret
861599-59-9
4-methyl-N-(2-(6-((2-oxo-2-((4-(trifluoromethoxy)phenyl)amino)ethyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)benzamide
872995-01-2
4-methyl-N-(2-(6-((2-((4-nitrophenyl)amino)-2-oxoethyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)benzamide
872995-03-4
methyl (2S)-2-amino-3-cyclopropylpropanoate
732231-41-3
Ethyl 2-(2-((3-(2-(4-methylbenzamido)ethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)thio)acetamido)benzoate
872995-04-5
N-(2-(6-((2-((4-acetylphenyl)amino)-2-oxoethyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)-4-methylbenzamide
872995-06-7
Ethyl 2-(2-((3-(2-(4-methylbenzamido)ethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)thio)acetamido)acetate
872995-09-0
7-Bromothiochromane
855997-36-3
Methyl 3-(1,3-benzodioxol-5-ylsulfamoyl)-4-phenylthiophene-2-carboxylate
899977-21-0
2-(Acetyloxy)-1-(2-thiazolyl)ethanone
3292-78-2
N-(2-(6-((2-((benzo[d][1,3]dioxol-5-ylmethyl)amino)-2-oxoethyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)-4-methylbenzamide
872995-12-5
Chemsrc provides Dithiobiuret(CAS#:541-53-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Dithiobiuret are included as well.>> amp version: Dithiobiuret

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved