MRS 1845

Modify Date: 2024-01-04 15:52:06

MRS 1845 Structure
MRS 1845 structure
Common Name MRS 1845
CAS Number 544478-19-5 Molecular Weight 398.41
Density 1.318g/cm3 Boiling Point 530.8ºC at 760 mmHg
Molecular Formula C21H22N2O6 Melting Point N/A
MSDS Chinese USA Flash Point 274.8ºC

 Use of MRS 1845


MRS1845 is a Ca2+ channel blocker with relative specificity for store-operated calcium entry (SOCE) channels[1].

 Names

Name 5-O-ethyl 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1-prop-2-ynyl-4H-pyridine-3,5-dicarboxylate
Synonym More Synonyms

 MRS 1845 Biological Activity

Description MRS1845 is a Ca2+ channel blocker with relative specificity for store-operated calcium entry (SOCE) channels[1].
Related Catalog
Target

Ca2+ channel[1]

References

[1]. Lee C, et al. Store-operated calcium channel inhibition attenuates neutrophil function and postshock acute lung injury. J Trauma. 2005 Jul;59(1):56-63.

 Chemical & Physical Properties

Density 1.318g/cm3
Boiling Point 530.8ºC at 760 mmHg
Molecular Formula C21H22N2O6
Molecular Weight 398.41
Flash Point 274.8ºC
Exact Mass 398.14800
PSA 101.66000
LogP 3.37240
Index of Refraction 1.595

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport

 Articles1

More Articles
GPR35 activation reduces Ca2+ transients and contributes to the kynurenic acid-dependent reduction of synaptic activity at CA3-CA1 synapses.

PLoS ONE 8 , e82180, (2013)

Limited information is available on the brain expression and role of GPR35, a Gi/o coupled receptor activated by kynurenic acid (KYNA). In mouse cultured astrocytes, we detected GPR35 transcript using...

 Synonyms

MRS 1845
N-Propargylnitrendipene
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