Betahistine EP Impurity C

Modify Date: 2024-01-10 03:50:00

Betahistine EP Impurity C Structure
Betahistine EP Impurity C structure
Common Name Betahistine EP Impurity C
CAS Number 5452-87-9 Molecular Weight 241.33100
Density 1.067g/cm3 Boiling Point 371.9ºC at 760mmHg
Molecular Formula C15H19N3 Melting Point N/A
MSDS N/A Flash Point 178.7ºC

 Use of Betahistine EP Impurity C


Betahistine EP Impurity C (NSC19005) is an impurity of Betahistine[1]. Betahistine is a potent, orally active and well-tolerated histamine H1 receptor agonist and H3 receptor antagonist used for the study of rheumatoid arthritis (RA)[2][3].

 Names

Name N-Methyl-N,N-bis(2-pyridylethyl)amine
Synonym More Synonyms

 Betahistine EP Impurity C Biological Activity

Description Betahistine EP Impurity C (NSC19005) is an impurity of Betahistine[1]. Betahistine is a potent, orally active and well-tolerated histamine H1 receptor agonist and H3 receptor antagonist used for the study of rheumatoid arthritis (RA)[2][3].
Related Catalog
In Vitro Betahistine (0-10 μM) inhibits [125I]iodoproxyfan binding to membranes of CHO (rH3(445)R) and CHO (hH3(445)R) cells with IC50 values of 1.9 μM and 3.3 μM, respectively. Lead to Ki values of 1.4 μM and 2.5 μM, respectively[3].
References

[1]. Murilo B. M. de Mello, et al. Characterization and in silico Mutagenic Assessment of a New Betahistine Degradation Impurity. J. Braz. Chem. Soc. vol.30 no.7 São Paulo July 2019 Epub July 04, 2019

[2]. Poyurovsky M, et al. The effect of betahistine, a histamine H1 receptor agonist/H3 antagonist, on olanzapine-induced weight gain in first-episode schizophrenia patients. Int Clin Psychopharmacol. 2005 Mar;20(2):101-3.

[3]. Betahistine EP Impurity C (NSC19005) is an impurity of Betahistine[1]. Betahistine is a potent, orally active and well-tolerated histamine H1 receptor agonist and H3 receptor antagonist used for the study of rheumatoid arthritis (RA)[2].

 Chemical & Physical Properties

Density 1.067g/cm3
Boiling Point 371.9ºC at 760mmHg
Molecular Formula C15H19N3
Molecular Weight 241.33100
Flash Point 178.7ºC
Exact Mass 241.15800
PSA 29.02000
LogP 2.19360
Index of Refraction 1.568
Storage condition -20℃

 Safety Information

HS Code 2933399090

 Customs

HS Code 2933399090
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

N-methyl-2-pyridin-2-yl-N-(2-pyridin-2-ylethyl)ethanamine
NSC19005
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