ML204
Modify Date: 2024-01-12 12:46:43
ML204 structure
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Common Name | ML204 | ||
|---|---|---|---|---|
| CAS Number | 5465-86-1 | Molecular Weight | 226.317 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 404.4±33.0 °C at 760 mmHg | |
| Molecular Formula | C15H18N2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 198.4±25.4 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of ML204ML204 is a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.IC50 value:Target: TRPC4/C5 inhibitorML204 inhibited TRPC4β-mediated intracellular Ca(2+) rise with an IC(50) value of 0.96 μm and exhibited 19-fold selectivity against muscarinic receptor-coupled TRPC6 channel activation. In whole-cell patch clamp recordings, ML204 blocked TRPC4β currents activated through either μ-opioid receptor stimulation or intracellular dialysis of guanosine 5'-3-O-(thio)triphosphate (GTPγS), suggesting a direct interaction of ML204 with TRPC4 channels rather than any interference with the signal transduction pathways. Selectivity studies showed no appreciable block by 10-20 μm ML204 of TRPV1, TRPV3, TRPA1, and TRPM8, as well as KCNQ2 and native voltage-gated sodium, potassium, and calcium channels in mouse dorsal root ganglion neurons. In isolated guinea pig ileal myocytes, ML204 blocked muscarinic cation currents activated by bath application of carbachol or intracellular infusion of GTPγS, demonstrating its effectiveness on native TRPC4 currents [1]. ML204 blocked TRPC4 channels in an electrophysiological assay with an IC value of 2.6 μM and was also active in fluorescent and electrophysiological assays in which TRPC4 channels were activated by different mechanisms, indicating direct block of TRPC4 channels. Selectivity for block of TRPC4 channels was examined in fluorescent and electrophysiological experiments against closely related TRPC channels and more distantly related TRPV, TRPA and TRPM channels, and against non-TRP ion channels. ML204 afforded good selectivity (19-fold) against TRPC6 channels and more modest selectivity against TRPC3 and TRPC5 (9-fold) channels [2]. |
| Name | 4-methyl-2-piperidin-1-ylquinoline |
|---|---|
| Synonym | More Synonyms |
| Description | ML204 is a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.IC50 value:Target: TRPC4/C5 inhibitorML204 inhibited TRPC4β-mediated intracellular Ca(2+) rise with an IC(50) value of 0.96 μm and exhibited 19-fold selectivity against muscarinic receptor-coupled TRPC6 channel activation. In whole-cell patch clamp recordings, ML204 blocked TRPC4β currents activated through either μ-opioid receptor stimulation or intracellular dialysis of guanosine 5'-3-O-(thio)triphosphate (GTPγS), suggesting a direct interaction of ML204 with TRPC4 channels rather than any interference with the signal transduction pathways. Selectivity studies showed no appreciable block by 10-20 μm ML204 of TRPV1, TRPV3, TRPA1, and TRPM8, as well as KCNQ2 and native voltage-gated sodium, potassium, and calcium channels in mouse dorsal root ganglion neurons. In isolated guinea pig ileal myocytes, ML204 blocked muscarinic cation currents activated by bath application of carbachol or intracellular infusion of GTPγS, demonstrating its effectiveness on native TRPC4 currents [1]. ML204 blocked TRPC4 channels in an electrophysiological assay with an IC value of 2.6 μM and was also active in fluorescent and electrophysiological assays in which TRPC4 channels were activated by different mechanisms, indicating direct block of TRPC4 channels. Selectivity for block of TRPC4 channels was examined in fluorescent and electrophysiological experiments against closely related TRPC channels and more distantly related TRPV, TRPA and TRPM channels, and against non-TRP ion channels. ML204 afforded good selectivity (19-fold) against TRPC6 channels and more modest selectivity against TRPC3 and TRPC5 (9-fold) channels [2]. |
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| Related Catalog | |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 404.4±33.0 °C at 760 mmHg |
| Molecular Formula | C15H18N2 |
| Molecular Weight | 226.317 |
| Flash Point | 198.4±25.4 °C |
| Exact Mass | 226.147003 |
| PSA | 16.13000 |
| LogP | 3.92 |
| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
| Index of Refraction | 1.617 |
| Storage condition | -20℃ |
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~89%
ML204 CAS#:5465-86-1 |
| Literature: Kidwai; Sapra; Dave Synthetic Communications, 2000 , vol. 30, # 24 p. 4479 - 4488 |
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~%
ML204 CAS#:5465-86-1 |
| Literature: Kobayashi, Kazuhiro; Yoneda, Keiichi; Miyamoto, Kazuna; Morikawa, Osamu; Konishi, Hisatoshi Tetrahedron, 2004 , vol. 60, # 50 p. 11639 - 11645 |
| Precursor 3 | |
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| DownStream 0 | |
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Do male secondary sexual characters correlate with testis size and sperm length in the small hairy maggot blowfly?
Zoology (Jena.) 118 , 439-45, (2015) The phenotype-linked fertility hypothesis proposes that secondary sexual characters (SSCs) advertise a male's fertility to prospective mates. However, findings from empirical studies attempting to tes... |
| Quinoline, 4-methyl-2-(1-piperidinyl)- |
| 4-methyl-2-piperidylquinoline |
| 4-methyl-2-(piperidin-1-yl)quinoline |
| 2-Piperidino-4-methyl-chinolin |
| ML204 |
| 4-Methyl-2-(1-piperidinyl)-quinoline |
| 4-Methyl-2-(1-piperidinyl)quinoline |
| 2-Piperidino-lepidin |