ML204

• 常用名: ML204
• 英文名: ML204
• CAS号: 5465-86-1
• 分子量: 226.317
• 密度: 1.1±0.1 g/cm3
• 沸点: 404.4±33.0 °C at 760 mmHg
• 分子式: C₁₅H₁₈N₂
• 熔点: N/A
• 闪点: 198.4±25.4 °C
• 符号: GHS07
• 信号词: Warning

ML204用途

ML204是TRPC4/C5离子通道新型高效抑制剂。

ML204名称

• 中文名: ML204
• 英文名: 4-methyl-2-piperidin-1-ylquinoline

ML204生物活性

• 描述: ML204是TRPC4/C5离子通道新型高效抑制剂。
• 相关类别:
  信号通路 >> 跨膜转运 >> TRP频道
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Miller M, et al. Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels. J Biol Chem. 2011 Sep 23;286(38):33436-46.

  [2]. Miller MR, et al. Novel Chemical Inhibitor of TRPC4 Channels. Probe Reports from the NIH Molecular Libraries Program [Internet].

ML204物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 404.4±33.0 °C at 760 mmHg
• 分子式: C₁₅H₁₈N₂
• 分子量: 226.317
• 闪点: 198.4±25.4 °C
• 精确质量: 226.147003
• PSA: 16.13000
• LogP: 3.92
• InChIKey: USYRQXDHKXGTCK-UHFFFAOYSA-N
• SMILES: Cc1cc(N2CCCCC2)nc2ccccc12
• 外观性状: 粉末
• 蒸汽压: 0.0±0.9 mmHg at 25°C
• 折射率: 1.617
• 储存条件: -20℃

ML204安全信息

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302
• 危险品运输编码: NONH for all modes of transport

ML204靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Specificity screen against TRPC6 for compounds that activate transient receptor poten... 来源：Johns Hopkins Ion Channel Center 靶标：short transient receptor potential channel 6 [Mus musculus] External Id：TRPC4_AG_Counter_C6

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Specificity screen against TRPC6 for compounds that inhibit transient receptor potent... 来源：Johns Hopkins Ion Channel Center 靶标：short transient receptor potential channel 6 [Mus musculus] External Id：TRPC4_Inh_Counter_C6

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

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ML204英文别名

• 4-methyl-2-piperidylquinoline
• 4-methyl-2-(piperidin-1-yl)quinoline
• 2-Piperidino-4-methyl-chinolin
• ML204
• 4-Methyl-2-(1-piperidinyl)-quinoline
• 4-Methyl-2-(1-piperidinyl)quinoline
• 2-Piperidino-lepidin