2-Chloro-9-(beta-D-ribofuranosyl)purine

Modify Date: 2024-02-01 16:43:02

2-Chloro-9-(beta-D-ribofuranosyl)purine Structure
2-Chloro-9-(beta-D-ribofuranosyl)purine structure
Common Name 2-Chloro-9-(beta-D-ribofuranosyl)purine
CAS Number 5466-11-5 Molecular Weight 286.67
Density 2.03g/cm3 Boiling Point 542.7ºC at 760 mmHg
Molecular Formula C10H11ClN4O4 Melting Point N/A
MSDS N/A Flash Point 282ºC

 Use of 2-Chloro-9-(beta-D-ribofuranosyl)purine


2-Chloro-9-(beta-D-ribofuranosyl)purine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

 Names

Name 2-(2-chloropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
Synonym More Synonyms

 2-Chloro-9-(beta-D-ribofuranosyl)purine Biological Activity

Description 2-Chloro-9-(beta-D-ribofuranosyl)purine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

 Chemical & Physical Properties

Density 2.03g/cm3
Boiling Point 542.7ºC at 760 mmHg
Molecular Formula C10H11ClN4O4
Molecular Weight 286.67
Flash Point 282ºC
Exact Mass 286.04700
PSA 113.52000
Index of Refraction 1.846

 Synthetic Route

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2-Chloro-9-(beta-D-ribofuranosyl)purine Structure

2-Chloro-9-(bet...

CAS#:5466-11-5

Literature: Gillerman, Irina; Fischer, Bilha Journal of Medicinal Chemistry, 2011 , vol. 54, # 1 p. 107 - 121

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2-Chloro-9-(beta-D-ribofuranosyl)purine Structure

2-Chloro-9-(bet...

CAS#:5466-11-5

Literature: Schaeffer; Thomas Journal of the American Chemical Society, 1958 , vol. 80, p. 4896,4898

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2-Chloro-9-(beta-D-ribofuranosyl)purine Structure

2-Chloro-9-(bet...

CAS#:5466-11-5

Literature: Gillerman, Irina; Fischer, Bilha Journal of Medicinal Chemistry, 2011 , vol. 54, # 1 p. 107 - 121

 Synonyms

2-Chloro-purine riboside
(1R)-1-(2-chloro-purin-9-yl)-D-1,4-anhydro-ribitol
2-Cl-nebularine
(2R,3R,4S,5R)-2-(2-chloro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
2-chloro-9-pentofuranosyl-9h-purine
(1R)-1-(2-Chlor-purin-9-yl)-D-1,4-anhydro-ribit
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