Shikonin
Shikonin structure
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Common Name | Shikonin | ||
|---|---|---|---|---|
| CAS Number | 54952-43-1 | Molecular Weight | 288.295 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 567.4±50.0 °C at 760 mmHg | |
| Molecular Formula | C16H16O5 | Melting Point | 149 °C | |
| MSDS | Chinese USA | Flash Point | 311.0±26.6 °C | |
| Symbol |
GHS07, GHS09 |
Signal Word | Warning | |
Use of Shikonin(Rac)-Shikonin (Shikonin) possesses anti-tumor activity. (Rac)-Shikonin (Shikonin) circumvents cancer drug resistance by induction of a necroptotic death[1][2]. |
| Name | Shikalkin |
|---|---|
| Synonym | More Synonyms |
| Description | (Rac)-Shikonin (Shikonin) possesses anti-tumor activity. (Rac)-Shikonin (Shikonin) circumvents cancer drug resistance by induction of a necroptotic death[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | Shikonin shows a similar potency toward drug-sensitive cancer cell lines (MCF-7 and HEK293) and their drug-resistant lines overexpressing P-glycoprotein, Bcl-2, or Bcl-xL, which account for most of the clinical cancer drug resistance[2]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 567.4±50.0 °C at 760 mmHg |
| Melting Point | 149 °C |
| Molecular Formula | C16H16O5 |
| Molecular Weight | 288.295 |
| Flash Point | 311.0±26.6 °C |
| Exact Mass | 288.099762 |
| PSA | 94.83000 |
| LogP | 4.35 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.642 |
| Symbol |
GHS07, GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H400 |
| Precautionary Statements | P273 |
| Hazard Codes | Xn |
| RIDADR | UN 3077 9 / PGIII |
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Inhibitory effect of Shikonin on Candida albicans growth.
Biol. Pharm. Bull. 35(11) , 1956-63, (2012) Our study showed that Shikonin (SK) could provide an action against almost all Candida albicans isolates tested. More importantly, to some Fluconazole (FCZ)-resistant Candida albicans, the action of S... |
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Screening for novel quorum-sensing inhibitors to interfere with the formation of Pseudomonas aeruginosa biofilm.
J. Med. Microbiol. 60(Pt 12) , 1827-34, (2011) The objective of this study was to screen for novel quorum-sensing inhibitors (QSIs) from traditional Chinese medicines (TCMs) that inhibit bacterial biofilm formation. Six of 46 active components fou... |
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Optimization of shikonin homogenate extraction from Arnebia euchroma using response surface methodology.
Molecules 18(1) , 466-81, (2013) An efficient homogenate extraction technique was employed for extracting shikonin from Arnebia euchroma. The homogenate extraction procedure was optimized and compared with other conventional extracti... |
| 5,8-Dihydroxy-2-(1-hydroxy-4-methylpent-3-en-1-yl)-1,4-naphthoquinone |
| 1,4-Naphthalenedione, 5,8-dihydroxy-2-[(1R)-1-hydroxy-4-methyl-3-penten-1-yl]- |
| Arnebin-4 |
| 1,4-Naphthoquinone, 5,8-dihydroxy-2-(1-hydroxy-4-methyl-3-pentenyl) |
| Alkannin |
| 5,8-Dihydroxy-2-[(1R)-1-hydroxy-4-methyl-3-penten-1-yl]-1,4-naphthoquinone |
| (±)-Alkannin |
| 5,8-Dihydroxy-2-(1-hydroxy-4-methyl-3-penten-1-yl)-1,4-naphthoquinone |
| (+)-Alkannin |
| 5,8-dihydroxy-2-(1-hydroxy-4-methylpent-3-en-1-yl)naphthalene-1,4-dione |
| 5,8-Dihydroxy-2-[(1R)-1-hydroxy-4-methylpent-3-en-1-yl]-1,4-naphthoquinone |
| 1,4-Naphthalenedione, 5,8-dihydroxy-2-[(1R)-1-hydroxy-4-methyl-3-pentenyl]- |
| 1,4-Naphthalenedione, 5,8-dihydroxy-2-(1-hydroxy-4-methyl-3-penten-1-yl)- |
| Shikonin |
| 5,8-Dihydroxy-2-(1-hydroxy-4-methylpent-3-enyl)naphthalene-1,4-dione |