Triprolidine hydrochloride

Modify Date: 2025-08-25 15:49:51

Triprolidine hydrochloride Structure
Triprolidine hydrochloride structure
 Common Name Triprolidine hydrochloride
CAS Number 550-70-9 Molecular Weight 314.85200
Density 1.061g/cm3 Boiling Point 435.4ºC at 760mmHg
Molecular Formula C19H23ClN2 Melting Point 59-61ºC
MSDS N/A Flash Point 217.1ºC

 Use of Triprolidine hydrochloride


Triprolidine is an oral active, first-generation histamine H1-receptor antagonist. Triprolidine can be used for the research of allergic rhinitis. triprolidine exhibits spinal motor and sensory block in rats[1][2][3].

 Names

Name triprolidine hydrochloride (anh.)
Synonym More Synonyms

 Triprolidine hydrochloride Biological Activity

Description Triprolidine is an oral active, first-generation histamine H1-receptor antagonist. Triprolidine can be used for the research of allergic rhinitis. triprolidine exhibits spinal motor and sensory block in rats[1][2][3].
Related Catalog
Target

H1 Receptor

In Vivo Triprolidine (292.81-1467.20 μg/kg; intrathecal injection) produces a dose-dependent effect of spinal motor and sensory block in rats[3]. Animal Model: Male Sprague-Dawley rat (300-350 g)[3] Dosage: 292.81 μg/kg, 488.02 μg/kg, 733.60μg/kg, 1098.83 μg/kg, 1467.20 μg/kg Administration: Intrathecal injection Result: Elicited a dose-dependent spinal block.
References

[1]. K J Simons, et al. An investigation of the H1-receptor antagonist triprolidine: pharmacokinetics and antihistaminic effects. J Allergy Clin Immunol. 1986 Feb;77(2):326-30.

[2]. D L Deal, et al. Disposition and metabolism of triprolidine in mice. Drug Metab Dispos. Nov-Dec 1992;20(6):920-7.

[3]. Jann-Inn Tzeng, et al. Spinal sensory and motor blockade by intrathecal doxylamine and triprolidine in rats. J Pharm Pharmacol. 2018 Dec;70(12):1654-1661.

 Chemical & Physical Properties

Density 1.061g/cm3
Boiling Point 435.4ºC at 760mmHg
Melting Point 59-61ºC
Molecular Formula C19H23ClN2
Molecular Weight 314.85200
Flash Point 217.1ºC
Exact Mass 314.15500
PSA 16.13000
LogP 4.65740
InChIKey WYUYEJNGHIOFOC-UHFFFAOYSA-N
SMILES Cc1ccc(C(=CCN2CCCC2)c2ccccn2)cc1.Cl
Storage condition 2-8°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UT7657000
CHEMICAL NAME :
Pyridine, 2-(3-(1-pyrrolidinyl)-1-p-tolylpropenyl)-, monohydrochloride, (E)-
CAS REGISTRY NUMBER :
550-70-9
LAST UPDATED :
199803
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C19-H22-N2.Cl-H
MOLECULAR WEIGHT :
314.89
WISWESSER LINE NOTATION :
T6NJ BYR D1&2- AT5NTJ &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
840 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 22,375,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
495 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,525,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
247 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,525,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
21 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 8,171,1953
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
>5 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - excitement Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 8,171,1953 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81570 No. of Facilities: 842 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 990 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81570 No. of Facilities: 178 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 2378 (estimated) No. of Female Employees: 1467 (estimated)

 Safety Information

Hazard Codes Xn
Risk Phrases 22-36/37/38
Safety Phrases 26-36
RIDADR UN 3249
WGK Germany 3
RTECS UT7658000
Packaging Group III
Hazard Class 6.1(b)
HS Code 2933990090

 Synthetic Route

triprolidine structure

triprolidine

CAS#:486-12-4

~51%

Triprolidine hydrochloride Structure

Triprolidine hy...

CAS#:550-70-9

Literature: HIKAL LIMITED Patent: WO2009/84035 A1, 2009 ; Location in patent: Page/Page column 11-12 ;
2-[(Z)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine structure

2-[(Z)-1-(4-met...

CAS#:13573-69-8

~%

Triprolidine hydrochloride Structure

Triprolidine hy...

CAS#:550-70-9

Literature: WO2007/141803 A2, ; Page/Page column 6-7 ;

 Precursor & DownStream

Precursor  1

DownStream  0

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Triprolidine hydrochlorideBioassay

View more

Name: Primary cell-based high-throughput screening assay for identification of compounds th...
Source: Johns Hopkins Ion Channel Center
Target: regulator of G-protein signaling 4 isoform 2 [Homo sapiens]
External Id: JHICC_RGS_Act_HTS
Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN
Name: Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay
Source: ChEMBL
Target: N/A
External Id: CHEMBL1266185
Name: ERK5 transcriptional activity HTS
Source: 24565
Target: N/A
External Id: ERK5 transcriptional activity-HTS
Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
Name: uHTS identification of small molecule activators of the adaptive arm of the Unfolded ...
Source: Burnham Center for Chemical Genomics
Target: N/A
External Id: BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay
Name: Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit...
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: N/A
External Id: HMS1315
Name: High throughput fluorescence intensity-based biochemical assay to screen for small mo...
Source: University of Pittsburgh Molecular Library Screening Center
Target: furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens]
External Id: MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.
Name: Fluorescence polarization to screen for inhibitor that competite the binding of FadD2...
Source: Broad Institute
Target: FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE)
External Id: 2147-01_Inhibitor_SinglePoint_HTS_Activity
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 Synonyms

EINECS 208-985-0
MFCD00039044
Triprolidine Hydrochloride
Triprolidine HCl
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