Naphazoline hydrochloride
Naphazoline hydrochloride structure
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Common Name | Naphazoline hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 550-99-2 | Molecular Weight | 246.735 | |
| Density | 1.15 g/cm3 | Boiling Point | 440.5ºC at 760 mmHg | |
| Molecular Formula | C14H15ClN2 | Melting Point | 254-260 °C | |
| MSDS | Chinese USA | Flash Point | 220.2ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
Use of Naphazoline hydrochlorideNaphazoline HCl is an ocular vasoconstrictor and imidazoline derivative sympathomimetic amine.Target: Adrenergic Receptorphazoline hydrochloride is the common name for 2-(1-naphthylmethyl)-2-imidazoline hydrochloride. It is a sympathomimetic agent with marked alpha adrenergic activity. It is a vasoconstrictor with a rapid action in reducing swelling when applied to mucous membrane. It acts on alpha-receptors in the arterioles of the conjunctiva to produce constriction, resulting in decreased congestion. It is an active ingredient in several over-the-counter formulations including Clear Eyes and Naphcon eye drops. From Wikipedia. |
Summary: Naphazoline hydrochloride (CAS: 550-99-2), molecular formula C14H15ClN2, molecular weight 246.735. This substance is a white crystalline powder with a melting point of 254-260 °C and is used as a vasoconstrictor for the eye. For research-use only, not for medical or clinical usage.
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | Naphazoline hydrochloride |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Naphazoline HCl is an ocular vasoconstrictor and imidazoline derivative sympathomimetic amine.Target: Adrenergic Receptorphazoline hydrochloride is the common name for 2-(1-naphthylmethyl)-2-imidazoline hydrochloride. It is a sympathomimetic agent with marked alpha adrenergic activity. It is a vasoconstrictor with a rapid action in reducing swelling when applied to mucous membrane. It acts on alpha-receptors in the arterioles of the conjunctiva to produce constriction, resulting in decreased congestion. It is an active ingredient in several over-the-counter formulations including Clear Eyes and Naphcon eye drops. From Wikipedia. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.15 g/cm3 |
|---|---|
| Boiling Point | 440.5ºC at 760 mmHg |
| Melting Point | 254-260 °C |
| Molecular Formula | C14H15ClN2 |
| Molecular Weight | 246.735 |
| Flash Point | 220.2ºC |
| Exact Mass | 246.092377 |
| PSA | 24.39000 |
| LogP | 2.95040 |
| InChIKey | DJDFFEBSKJCGHC-UHFFFAOYSA-N |
| SMILES | Cl.c1ccc2c(CC3=NCCN3)cccc2c1 |
| Water Solubility | 170 g/L (20 ºC) |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H300 |
| Precautionary Statements | Missing Phrase - N15.00950417 |
| Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
| Hazard Codes | T:Toxic |
| Risk Phrases | R20/21/22;R23/24/25 |
| Safety Phrases | S45-S36/37/39-S24/25 |
| RIDADR | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | NJ4375000 |
| Packaging Group | III |
| Hazard Class | 6.1 |
| HS Code | 2934999090 |
This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Report: Simultaneous determination of naphazoline hydrochloride, chlorpheniramine maleate and methylene blue in their ternary mixture.
Pak. J. Pharm. Sci. 26(3) , 641-8, (2013) Validated spectrophotometric and chemometric methods were developed for determination of Naphazoline Hydrochloride (NAP), Chlorpheniramine maleate (CLO) and Methylene blue (MB) in their ternary mixtur... |
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Method development for impurity profiling in SFC: The selection of a dissimilar set of stationary phases.
J. Pharm. Biomed. Anal. 111 , 333-43, (2015) Supercritical fluid chromatography (SFC) is drawing considerable interest as separation technique in the pharmaceutical industry. The technique is already well established in chiral separations both a... |
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Dilute brimonidine to improve patient comfort and subconjunctival hemorrhage after LASIK.
J. Refract. Surg. 29(7) , 469-75, (2013) To investigate whether dilute brimonidine (0.025%) reduces patient discomfort, subconjunctival hemorrhage, and injection after LASIK without a significant increase in the rate of flap complications or... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Inhibition of SARS-CoV-2-induced cytopathy was measured 4 days after infection of EGF...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL5303712
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Name: Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay
Source: ChEMBL
Target: N/A
External Id: CHEMBL1266185
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Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
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Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN
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Name: qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity
Source: NCGC
External Id: HERG01
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Name: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen
Source: NCGC
Target: N/A
External Id: SMAD3201
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Name: uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay
Source: Burnham Center for Chemical Genomics
Target: cystic fibrosis transmembrane conductance regulator [Homo sapiens]
External Id: SBCCG-A764-CF-PAF-Primary-Assay
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify ant...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_ANT_FLUO8_1536_1X%INH PRUN
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Naphcon |
| 2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole hydrochloride (1:1) |
| 2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole,hydrochloride |
| Naphazoline hydrochloride |
| EINECS 208-989-2 |
| 2-(1-naphthylmethyl)-4,5-dihydro-1H-imidazole hydrochloride |
| 2-(1-Naphthylmethyl)-4,5-dihydro-1H-imidazole hydrochloride (1:1) |
| 1H-Imidazole, 4,5-dihydro-2-(1-naphthalenylmethyl)-, hydrochloride (1:1) |
| MFCD00012554 |
| 2-(1-Naphthylmethyl)-2-imidazoline hydrochloride |
| Naphazoline (hydrochloride) |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the safety information for Naphazoline hydrochloride? |
| A: Safety information for Naphazoline hydrochloride: S45-S36/37/39-S24/25. |
| Q: What is the molecular formula of Naphazoline hydrochloride? |
| A: Molecular formula of Naphazoline hydrochloride is C14H15ClN2. |
| Q: What is the molecular weight of Naphazoline hydrochloride? |
| A: Molecular weight of Naphazoline hydrochloride is 246.735. |
| Q: What is the boiling point of Naphazoline hydrochloride? |
| A: Boiling point of Naphazoline hydrochloride is 440.5ºC at 760 mmHg. |
| Q: What is the SMILES notation of Naphazoline hydrochloride? |
| A: SMILES notation of Naphazoline hydrochloride is Cl.c1ccc2c(CC3=NCCN3)cccc2c1. |
| Q: What is the CAS number of Naphazoline hydrochloride? |
| A: CAS number of Naphazoline hydrochloride is 550-99-2. |
| Q: What is the LogP of Naphazoline hydrochloride? |
| A: LogP of Naphazoline hydrochloride is 2.95040. |
| Q: What is the melting point of Naphazoline hydrochloride? |
| A: Melting point of Naphazoline hydrochloride is 254-260 °C. |
| Q: How is the water solubility of Naphazoline hydrochloride? |
| A: Water solubility of Naphazoline hydrochloride: 170 g/L (20 ºC). |
| Q: What is the English name of Naphazoline hydrochloride? |
| A: The English name of Naphazoline hydrochloride is Naphazoline hydrochloride. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |
| Henan Tianfu Chemical Co., Ltd. |